Research and Clinical Interests

The laboratory of Dr. Zagzag has focused on three main areas: 1) Pathology of the nervous system, 2) Mechanisms of cerebral vasculogenesis and angiogenesis, 3) Molecular mechanisms behind the process of glioma invasion. This work has led to more than 145 publications.

Selected Publications

Williams SC, Karajannis MA, Chiriboga L, Golfinos JG, von Deimling A, Zagzag D. R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma. Acta Neuropathol. 2011 Feb;121(2):279-81. Epub 2010 Dec 24. Cited in Pubmed; PMID 21181477. doi: 10.1007/s00401-010-0790-y.

Chen GJ, Karajannis M, Newcomb EW, Zagzag D. Overexpression and Activation of Epidermal Growth Factor Receptor in Hemangioblastomas. J Neurooncol. 2010 Sep;99(2):195-200. Epub 2010 Feb 22. Cited in Pubmed; PMID 20730556. doi: 10.1007/s11060-010-0125-9. PMCID: PMC2928155.

Méndez O, J Zavadil, Esencay M, Lukyanov Y, Santovasi D, Wang SC, Newcomb EW, Zagzag D. Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol Cancer. 2010 Jun 1;9(133):Cited in Pubmed; PMID 20515450. doi: 10.1186/1476-4598-9-133. PMCID: PMC2896954.

Newcomb EW, Lukyanov Y, Esencay M, Zagzag D. The geldanamycin analogue 17-AAG inhibits the growth of GL261 glioma cells in vitro and in vivo. Anticancer Drugs. 2007 Sep;18(8):875-82. Cited in Pubmed; PMID 17667592.

Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest. 2006 Dec;86(12):1221-32. Epub 2006 Oct 30. Cited in Pubmed; PMID 17075581. doi: 10.1038/labinvest.3700482.

Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005 Jul 15;65(14):6178-88. Cited in Pubmed; PMID 16024619. doi: 10.1158/0008-5472.CAN-04-4406.

Zagzag D, Salnikow K, Chiriboga L, Yee H, Lan L, Ali MA, Garcia R, Demaria S, Newcomb EW. Downregulation of major histocompatibility complex antigens in invading glioma cells: Stealth invasion of the brain. Lab Invest. 2005 Mar;85(3):328-41. Cited in Pubmed; PMID 15716863. doi: 10.1038/labinvest.3700233.

Zagzag D, Blanco C, Friedlander DR, Miller DC, Newcomb E. Expression of p27KIP1 in human gliomas: Relationship between tumor grade, proliferation index, and patient survival. Hum Pathol. 2003 Jan;34(1):48-53. Cited in Pubmed; PMID 12605366. doi: 10.1053/hupa.2003.54.

Zagzag D, Miller DC, Chiriboga L, Yee H, Newcomb EW. Green fluorescent protein immunohistochemistry as a novel experimental tool for the detection of glioma cell invasion in vivo. Brain Pathol. 2003 Jan;13(1):34-7. Cited in Pubmed; PMID 12580543.

Zagzag D, Shiff B, Jallo GI, Greco MA, Blanco C, Cohen H, Hukin J, Allen JC, Friedlander DR. Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase. Cancer Res. 2002 May 1;62(9):2660-8. Cited in Pubmed; PMID 11980665.

Zagzag D, Miller DC, Knopp E, Farmer JP, Lee M, Biria S, Pellicer A, Epstein FJ, Allen JC. Primitive neuroectodermal tumors of the brainstem: investigation of seven cases. Pediatrics. 2000 Nov;106(5):1045-53. Cited in Pubmed; PMID 11061774.

Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1α in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000 Jun 1;88(11):2606-18. Cited in Pubmed; PMID 10861440. doi: 10.1002/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W.

Selected Books and Reviews

Karajannis M, Zagzag, D. Molecular Pathology of Central Nervous System Neoplasms: Molecular Pathology Library. Cagle P, series editor (forthcoming). New York: Springer; 2012.

Gagner JP, Golfinos JG, Graber JJ, Zagzag D. Molecular basis of glioma neovascularization and its therapeutic applications. In: Mehta MP, et al, editors. Principles and Practice of Neuro-Oncology: a Multidisciplinary Approach. New York: Demos Medical Publishing (forthcoming); 2010.

Newcomb EW, Zagzag D. HIF-1 Regulation of Chemokine Receptor Expression. In: Fulton AE, editor. Chemokine Receptors in Cancer. New York: Humana Press; 2009. pp. 47-61.

Newcomb EW, Zagzag D. The murine GL261 glioma experimental model to assess novel brain tumor treatments. In: van Meir E, editor. CNS Cancer, Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches. New York: Humana Press; 2009. pp. 227-41.

Plate KH, Vortmeyer AO, Zagzag D, Neumann HPH. Von Hippel-Lindau Disease and Haemangioblastoma. In: WHO Classification of Tumours Pathology and Genetics of Tumours of Nervous System. 2007. pp. 215-217.

Aldape KD, Plate KH, Vortmeyer AO, Zagzag D, Neumann HPH. Haemangioblastoma. In: WHO Classification of Tumours Pathology and Genetics of Tumours of Nervous System. 2007. pp. 184-186.

Zagzag D, Newcomb EW. Symposium - Angiogenesis in gliomas. Brain Pathol. 2005;4:296.

Hummel-Levine P, Zagzag D. Cytopathology of the Central Nervous System. 2nd edition. Atkinson Textbook; 2004.

Zagzag D, Chen W. mRNA Detection in Cerebral Vessels by Nonradioactive In Situ Hybridization. In: Nag S, editor. The Blood-Brain Barrier. Meth Mol Med. 89. Humana Press Inc; 2003. pp. 451-63.

Zagzag D, Capo V. Angiogenesis in the central nervous system: a role for vascular endothelial growth factor/vascular permeability factor and tenascin-C. Common molecular effectors in cerebral neoplastic and non-neoplastic "angiogenic diseases" . Histol Histopathol. 2002;17:301-21.

Zagzag D, Friedlander DR, Margolis B, Grumet M, Semenza GL, Zhong H, Simons JW, Holash J, Wiegand SJ, Yancopoulos GD. Molecular events implicated in brain tumor angiogenesis and invasion. Pediatr Neurosurg. 2000;33:49-55.

Greco MA, Zagzag D. AIDS Pediatric Pathology. In: Schwarts DA, Connor DH, Chandler FW, editors. Diagnostic Pathology of Infectious Diseases. Appleton & Longe; 1997. pp. 169-81.

Jagirdar J, Zagzag D. Pathology and Insights into Pathogenesis of Tuberculosis. In: Rom WN, Garay S, editors. Tuberculosis. Little, Brown & Company; 1996. pp. 467-82.

Zagzag D. Angiogenic growth factors in neural embryogenesis and neoplasia. Am J Pathol. 1995;146:293-309.

Organizational Associations

American Association for Neuropathologists, 1993- present; American Association for Cancer Research, 1995- present; Society for Neuro-Oncology, 2003- present; North American Vascular Biology Organization, 2007-present.

Editorships and Editorial Boards
Section Editor, Neuropathology, Archives of Pathology and Laboratory Medicine; Editorial Board Member, Brain Pathology; Editorial Board Member, American Journal of Pathology.

Selected Awards

1981: The "Laureat" Award for excellence in Medical School
1988: "Dean's Honor List" for Ph.D. Thesis, McGill University
1999: Lucien J. Rubenstein Award for the best paper on Neuro-Oncology at the American Association of Neuropathologists Meeting, Portland, OR
2005: Teacher of the Year Award, NYU School of Medicine
2006: Award for Excellence in Clinical Science, Society for Neuro-Oncology
2007: Pioneer Award, Children's Brain Tumor Foundation
2008: Teacher of the Year Award, NYU School of Medicine
2010: NYU Distinguished Teaching Award. More details available in News and Views

"Best Doctors" Lists
New York magazine's "Best Doctors" Lists
2009: Top Doctors in New York, New York Magazine
2009: Top Doctors: New York Metro Area 12th ed. Castle Connolly Medical Ltd.
2009: Top Cancer Doctors in America, Castle Connolly Medical Ltd.
2010: America's Top Doctors, Castle Connolly Medical Ltd.
2010: New York Metro Area Top Doctors, Castle Connolly Medical Ltd.
2010: Top Doctors in New York, New York Magazine
2011: New York Metro Area Top Doctors, Castle Connolly Medical Ltd.

Hospital Affiliations

Tisch Hospital
Bellevue Hospital

Additional Information

Research Profile