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Research and Clinical Interests

Pathology of nervous system, mechanisms of cerebral vasculogenesis and angiogenesis

Selected Publications

Newcomb EW, Lukyanov Y, Esencay M, Zagzag D. The geldanamycin analogue 17-AAG inhibits the growth of GL261 glioma cells in vitro and in vivo. Anticancer Drugs. 2007 Sep;18(8):875-82. Cited in Pubmed; PMID 17667592.

Nomura N, Nomura M, Newcomb EW, Zagzag D. Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1. Biochem Pharmacol. 2007;73:1528-36. Cited in Pubmed; PMID 17324379.

Pivawer G, Law M, Zagzag D. Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme. Magn Reson Imaging. 2007;25:238-43. Cited in Pubmed; PMID 17275620.

Law M, Brodsky JE, Babb J, Rosenblum M, Miller DC, Zagzag D, Gruber ML, Johnson G. High cerebral blood volume in human gliomas predicts deletion of chromosome 1p: Preliminary results of molecular studies in gliomas with elevated perfusion. J Magn Reson Imaging. 2007;25:1113-9. Cited in Pubmed; PMID 17520715.

Law M, Young R, Babb J, Rad M, Sasaki T, Zagzag D, Johnson G. Comparing perfusion metrics obtained from a single compartment versus pharmacokinetic modeling methods using dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. Am J Neuroradiol. 2006;27:1975-82. Cited in Pubmed; PMID 17032878.

Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. HIF-1-dependent repression of E-cadherin in VHL-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006;66:2725-31. Cited in Pubmed; PMID 16510593.

Newcomb EW, Lukyanov E, Schnee T, Ali MA, Lan L, Zagzag D. Noscapine inhibits hypoxia-mediated HIF-1alpha expression and angiogenesis in vitro: a novel function for an old drug. Int J Oncol. 2006;28:1121-30. Cited in Pubmed; PMID 16596228.

Law M, Oh S, Babb JS, Wang E, Inglese M, Zagzag D, Knopp EA, Johnson G. Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging--prediction of patient clinical response. Radiology. 2006;238:658-67. Cited in Pubmed; PMID 16396838.

Newcomb EW, Demaria S, Lukyanov Y, Shao Y, Schnee T, Kawashima N, Lan L, Dewyngaert JK, Zagzag D, McBride WH, Formenti SC. The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas. Clin Cancer Res. 2006;12:4730-37. Cited in Pubmed; PMID 16899624.

Newcomb EW, Lymberis SC, Lukyanov Y, Shao Y, Schnee T, Devitt M, Rosenstein BS, Zagzag D, Formenti SC. Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol. Cell Cycle. 2006;25:93-9. Cited in Pubmed; PMID 16319534.

Law M, Oh S, Johnson G, Babb JS, Zagzag D, Golfinos J, Kelly PJ. Perfusion magnetic resonance imaging predicts patient outcome as an adjunct to histopathology: a second reference standard in the surgical and nonsurgical treatment of low-grade gliomas. Neurosurgery. 2006;58:1099-1107. Cited in Pubmed; PMID 16723889.

Wensky AK, Furtado GC, Garibaldi Marconedes MC, Chen S, Manfra D, Lira SA, Zazzag D, Lafaille JJ. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. Immunol. 2005 Feb 1;174(3):1416-23. Cited in Pubmed; PMID 15661899.

Fischer I, Gagner JP, Law M, Newcomb EW, Zagzag D. Angiogenesis in gliomas: biology and molecular pathophysiology. Brain Pathol. 2005;4:297-310. Cited in Pubmed; PMID 16389942.

Gagner JP, Law M, Fischer I, Newcomb EW, Zagzag D. Angiogenesis in gliomas: imaging and experimental therapeutics. Brain Pathol. 2005;4:342-63. Cited in Pubmed; PMID 16389946.

Cohen BA, Knopp EA, Rusinek H, Babb JS, Zagzag D, Gonen O. Assessing global invasion of newly diagnosed glial tumors with whole-brain proton MR spectroscopy. Am J Neuroradiol. 2005;26:2170-77. Cited in Pubmed; PMID 16219818.

Selected Books

Wang BY, Zagzag D, Nonaka D. Chapter 12: Tumors of the Central Nervous System. In: Barnes L, editor. Surgical Pathology of the Head and Neck. 3rd edition. New York: Taylor & Francis Group; 2008. pp. 669-772.

Aldape KD, Plate KH, Vortmeyer AO, Zagzag D, Neumann HPH. Haemangioblastoma. In: WHO Classification of Tumours Pathology and Genetics of Tumours of Nervous System. Forthcoming. 2007.

Plate KH, Vortmeyer AO, Zagzag D, Neumann HPH. Von Hippel-Lindau Disease and Haemangioblastoma. In: WHO Classification of Tumours Pathology and Genetics of Tumours of Nervous System. Forthcoming. 2007.

Hummel-Levine P, Zagzag D. Cytopathology of the Central Nervous System. 2nd edition. Atkinson Textbook; 2004.

Zagzag D, Chen W. mRNA Detection in Cerebral Vessels by Nonradioactive In Situ Hybridization. In: Nag S, editor. The Blood-Brain Barrier. Meth Mol Med. 89. Humana Press Inc; 2003. pp. 451-63.

Greco MA, Zagzag D. AIDS Pediatric Pathology. In: Schwarts DA, Connor DH, Chandler FW, editors. Diagnostic Pathology of Infectious Diseases. Appleton & Longe; 1997. pp. 169-81.

Jagirdar J, Zagzag D. Pathology and Insights into Pathogenesis of Tuberculosis. In: Rom WN, Garay S, editors. Tuberculosis. Little, Brown & Company; 1996. pp. 467-82.

Organizational Associations

American Association for Neuropathologists, 1993- present; American Association for Cancer Research, 1995- present; Society for Neuro-Oncology, 2003- present

Selected Awards

The "Laureat" Award for excellence in Medical School, June 1981
"Dean's Honor List" for Ph.D. Thesis, McGill University, May 1988
Lucien J. Rubenstein Award for the best paper on Neuro-Oncology at the American Association of Neuropathologists Meeting, Portland, OR, June 1999
Teacher of the Year Award, NYU School of Medicine, May 2005
Award for Excellence in Clinical Science, Society for Neuro-Oncology
Teacher of the Year Award, NYU School of Medicine Class of 2010
Named one of New York magazine's Best Doctors

Hospital Affiliations

Tisch Hospital
Bellevue Hospital

Additional Information

Research Profile