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Research and Clinical Interests

My research interests mainly focus on the early events of genetic alterations in the colorectal, heptocellular and pancreatic carcinogenesis, and identification of biomarkers to assist in diagnosis and prognostication. My clinical interests include gastrointestinal and liver pathology, and molecular diagnostics in hematology, oncology, genetics, and microbiology.

Selected Publications

Xu R, Bu-Ghanim M, Fiel MI, Schiano T, Cohen E, Thung SN. Hepatocellular carcinoma associated with an atypical presentation of Wilson's disease. Semin Liver Dis. 2007 Feb;27(1):122–7. Cited in Pubmed; PMID 17295181.

Blumenberg M, Gao S, Dickman K, Grollman AP, Bottinger EP, Zavadil J. Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition. Cells Tissues Organs. 2007;185(1-3):162–74. Cited in Pubmed; PMID 17587822.

Emanuel P, Pertsemlidis DS, Gordon R, Xu R. Benign hybrid perineurioma-schwannoma in the colon. Ann Diagn Pathol. 2006 Dec;10(6):367-70. Cited in Pubmed; PMID 17126257.

Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N. Microcarcinoids in large intestinal adenomas. Am J Surg Pathol. 2006 Dec;30(12):1531–6. Cited in Pubmed; PMID 17122508.

Fukata M, Chen A, Klepper A, Krishnareddy S, Vamadevan AS, Thomas LS, Xu R, Inoue H, Arditi M, Dannenberg AJ, Abreu MT. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology. 2006 Sep;131(3):862–7. Cited in Pubmed; PMID 16952555.

Wu HS, Xu R, Harpaz N, Burstein D, Gil J. Segmentation of microscopic images of small intestinal glands with directional 2-D filters. Anal Quant Cytol Histol. 2005 Oct;27(5):291-300. Cited in Pubmed; PMID 16447822.

Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, Lukasek K, Nast CC, Lechago J, Xu R, Naiki Y, Soliman A, Arditi M, Abreu MT. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):15826931. Cited in Pubmed; PMID 15826931.

Levi G, Bu-Ghanim M, Xu R, Cohen E, Abittan C, Roayaie S. A 48-year-old obese man with a 3 cm liver lesion and a history of hemochromatosis and lymphoma. Semin Liver Dis. 2004 Aug;24(3):327-32. Cited in Pubmed; PMID 15349809.

Joffe HV, Xu R, Johnson FB, Longtine J, Kucher N, Goldhaber SZ. Warfarin dosing and cytochrome P450 2C9 polymorphisms. Thromb Haemost. 2004 Jun;91(6):1123–8. Cited in Pubmed; PMID 15175798.

Xu R, Jaffer S. Is metastatic potential of breast cancer inherent or acquired? Lab Invest. 2004 Apr;84(4):395–6. Cited in Pubmed; PMID 15112372.

Suriawinata A, Xu R. An update on the molecular genetics of hepatocellular carcinoma. Semin Liver Dis. 2004 Feb;24(1):77-88. Cited in Pubmed; PMID 15085488.

Xu R, Feiner H, Li P, Yee H, Inghirami G, Delgado Y, Perle MA. Differential amplification and overexpression of HER-2/neu, p53, MIB1, and estrogen receptor/progesterone receptor among medullary carcinoma, atypical medullary carcinoma, and high-grade invasive ductal carcinoma of breast. Arch Pathol Lab Med. 2003 Nov;127(11):1458–64. Cited in Pubmed; PMID 14567723.

Xu R, Ogino S, Lip V, Fang H, Wu BL. Comparison of PCR-RFLP with allele-specific PCR in genetic testing for spinal muscular atrophy. Genet Test. 2003;7(4):277-81. Cited in Pubmed; PMID 15000803.

Xu R, Murray M, Jagirdar J, Delgado Y, Melamed J. Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma. Arch Pathol Lab Med. 2002 May;126(5):562-6. Cited in Pubmed; PMID 11958661.

Xu R, Perle MA, Inghirami G, Chan W, Delgado Y, Feiner H. Amplification of Her-2/neu gene in Her-2/neu-overexpressing and -nonexpressing breast carcinomas and their synchronous benign, premalignant, and metastatic lesions detected by FISH in archival material. Mod Pathol. 2002 Feb;15(2):116–24. Cited in Pubmed; PMID 11850540.

Selected Books

Xu R. Non-amplification methods and DNA separation methods. In: Jian L, Zhang D, editors. Essentials of Molecular Genetic Pathology, Diagnostic Methodology and Technology Section. Detroit, MI: Human Press; 2007.

Xu R, Yuan S. Clinical application of microscopic morphometry in human tumor pathology. In: Wu H, editor. Image Analysis in Medical Microscopy and Pathology. Kerala, India: Transworld Research Network; 2007.

Organizational Associations

United States and Canadian Academy of Pathology (1998-); Association for Molecular Pathology (2006-)

Hospital Affiliations

Tisch Hospital
Bellevue Hospital
Clinical Pathology Hospital