E. Sergio Trombetta, Pharm.D., Ph.D.
Assistant Professor of Pathology
Immunology, Molecular Oncology / Dendritic cell function in innate and adaptive immunity
trombs02@nyumc.org, (212) 263 9278
522 First Avenue, SRB 1311, New York, NY 10016
Research and Clinical Interests
Our lab studies antigen presenting cells and their role in T-cell stimulation. Our goal is to contribute to the understanding the modulation of T-cell function, with the potential to design improved immunotherapies.
Selected Publications
Monu N, Trombetta ES. Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules. Curr Opin Immunol. 2007 Feb;19(1):66-72. Cited in Pubmed; PMID 17157489.
Delamarre L, Couture R, Mellman I, Trombetta ES. Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med. 2006 Sep 4;203(9):2049-55. Epub 2006 Aug 14. Cited in Pubmed; PMID 16908625.
Touret N, Paroutis P, Terebiznik M, Harrison RE, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S. Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell. 2005 Oct 7;123(1):157-70. Cited in Pubmed; PMID 16213220.
Trombetta ES, Parodi AJ. Glycoprotein reglucosylation. Methods. 2005 Apr;35(4):328-37. Cited in Pubmed; PMID 15804604.
Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005 Mar 11;307(5715):1630-4. Cited in Pubmed; PMID 15761154.
Trombetta ES, Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol. 2005;23:975-1028. Cited in Pubmed; PMID 15771591.
Trombetta ES. The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis. Glycobiology. 2003 Sep;13(9):77R-91R. Epub 2003 May 7. Cited in Pubmed; PMID 12736198.
Trombetta ES, Ebersold M, Garrett W, Pypaert M, Mellman I. Activation of lysosomal function during dendritic cell maturation. Science. 2003 Feb 28;299(5611):1400-3. Cited in Pubmed; PMID 12610307.
Trombetta ES, Parodi AJ. Quality control and protein folding in the secretory pathway. Annu Rev Cell Dev Biol. 2003;19:649-76. Cited in Pubmed; PMID 14570585.
Trombetta ES, Parodi AJ. N-glycan processing and glycoprotein folding. Adv Protein Chem. 2001;59:303-44. Cited in Pubmed; PMID 11868276.
Garrett WS, Chen LM, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galán JE, Mellman I. Developmental control of endocytosis in dendritic cells by Cdc42. Cell. 2000 Aug 4;102(3):325-34. Cited in Pubmed; PMID 10975523.
Trombetta ES, Helenius A. Conformational requirements for glycoprotein reglucosylation in the endoplasmic reticulum. J Cell Biol. 2000 Mar 20;148(6):1123-29. Cited in Pubmed; PMID 10725325.
Trombetta ES, Helenius A. Glycoprotein reglucosylation and nucleotide sugar utilization in the secretory pathway: identification of a nucleoside diphosphatase in the endoplasmic reticulum. EMBO J. 1999 Jun 15;18(12):3282-92. Cited in Pubmed; PMID 10369669.
Trombetta ES, Helenius A. Lectins as chaperones in glycoprotein folding. Curr Opin Struct Biol. 1998 Oct;8(5):587-92. Cited in Pubmed; PMID 9818262.
