Research and Clinical Interests

Dr. Smith’s research is focused on the molecular mechanisms controlling telomere function in human cells. Telomere integrity is essential for chromosome stability and maintenance, and telomeres play a key role in ageing and cancer. Dr. Smith’s laboratory is taking cell biological, biochemical and genetic approaches to identify and characterize telomere-associated proteins and to elucidate their role in telomere replication, protection, and sister chromatid cohesion.

Selected Publications

Canudas S, Houghtaling BR, Bhanot M, Sasa G, Savage SA, Bertuch AA, Smith S. A role for heterochromatin protein 1{gamma} at human telomeres. Genes Dev. 2011 Sep 1;25(17):1807-19. Epub 2011 Aug 4. Cited in Pubmed; PMID 21865325. doi: 10.1101/gad.17325211.

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F. Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8. Epub 2011 Jan 26. Cited in Pubmed; PMID 21270334. doi: 10.1073/pnas.1016574108. PMCID: PMC3041075.

Canudas S, Smith S. Differential regulation of telomere and centromere cohesion by the SCC3 homologs SA1 and SA2, respectively, in human cells. J Cell Biol. 2009 Oct 19;187(2):165-73. Epub 2009 Oct 12. Cited in Pubmed; PMID 19822671. doi: 10.1083/jcb.200903096. PMCID: 2768842.

Smith S. The SAGA the end. Mol Cell. 2009 Aug 14;35(3):352-64. Cited in Pubmed; PMID 19683489. doi: 10.1016/j.molcel.2009.07.011.

Smith S. The long and short of it: A new isoform of TIN2 in the nuclear matrix. Cell Cycle. 2009 Mar 15;8(6):797-8. Epub 2009 Mar 15. Cited in Pubmed; PMID 19279399.

Hsiao SJ, Smith S. Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ. J Cell Biol. 2009 Feb 23;184(4):515-26. Epub 2009 Feb 16. Cited in Pubmed; PMID 19221198. doi: 10.1083/jcb.200810132.

Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ. Tankyrase 1 and Tankyrase 2 are essential but redundant for mouse embryonic development. PLoS ONE. 2008 Jul 9;3(7):e2639. Cited in Pubmed; PMID 18612384. doi: doi/10.1371/journal.pone.0002639.

Hsiao SJ, Smith S. Tankyrase function at telomeres, spindle poles, and beyond. Biochimie. 2008 Jan;90(1):83-92. Epub 2007 Jul 24. Cited in Pubmed; PMID 17825467. doi: 10.1016/j.biochi.2007.07.012.

Canudas S, Houghtaling BR, Kim J, Dynek JN, Chang WG, Smith S. Protein requirements for sister telomere association in human cells. EMBO J. 2007 Nov 28;26(23):4867-78. Epub 2007 Oct 25. Cited in Pubmed; PMID 17962804. doi: 10.1038/sj.emboj.7601903.

Hsiao SJ, Poitras MF, Cook BD, Liu Y, Smith S. Tankyrase 2 PARP domain deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol. 2006 Mar;26:2044–54. Cited in Pubmed; PMID 16507985.

Chang W, Dynek JN, Smith S. NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. Biochem J. 2005;391:177–84. Cited in Pubmed; PMID 16076287.

Dynek JN, Smith S. Resolution of Sister telomere association is required for mitotic progression in human cells. Science. 2004 Apr 2;304:97–100. Cited in Pubmed; PMID 15064417.

Seimya H, Murimatsu Y, Smith S, Tsuruo T. A functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation. Mol Cell Biol. 2004 Mar;24:1944–55. Cited in Pubmed; PMID 14966275.

Houghtaling BR, Cuttonaro L, Chang W, Smith S. A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol. 2004;14:1621–31. Cited in Pubmed; PMID 15380063.

Chang W, Dynek J, Smith S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev. 2003 Jun 1;17:1328–33. Cited in Pubmed; PMID 12782650.

Organizational Associations

The American Association for the Advancement of Science; The American Society for Cell Biology; The Harvey Society; New York Academy of Sciences

Selected Awards

1990-1993 Damon Runyon-Walter Winchel Cancer Research Fellowship
1996-1999 Special Fellow of The Leukemia and Lymphoma Society
2000-2002 Kimmel Scholar Award
2000-2003 Edward Mallinckrodt Jr. Foundation
2000-2003 The New York Academy of Medicine Speaker's Fund for Biomedical Research