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Research and Clinical Interests

Dr. Singh is interested in pathobiology of diseases of breast, with a focus on translational research. He is Co-Chair of the breast pathology cadre of CALGB and pathology chair of two CALGB neo-adjuvant chemotherapy trials. Dr. Singh is a Co-PI with Dr. Kleinberg (PI) for a breast cancer chemoprevention trial using SOM230, an anti-IGF-1 action inhibitor. He collaborates with numerous other basic and clinical investigators to test hypotheses using pathological samples. As Director of Biorepositories at NYU Cancer Institute, he has successfully initiated a novel consenting process and created a virtual tissue repository integrating various biospecimen repositories at NYUCI, which is being modeled for institution-wide usage.

Selected Publications

Guth AA, Mercado C, Roses DF, Darvishian F, Singh B, Cangiarella JF. Microinvasive breast cancer and the role of sentinel node biopsy: an institutional experience and review of the literature. Breast J. 2008 Jul;14(4):335-9. Cited in Pubmed; PMID 18537917. doi: 10.1111/j.1524-4741.2008.00594.x.

Axelrod D, Smith J, Kornreich D, Grinstead E, Singh B, Cangiarella J, Guth AA. Breast cancer in young women. J Am Coll Surg. 2008 Jun;206(3):1193-203. Epub 2008 Apr 24. Cited in Pubmed; PMID 18501818. doi: 10.1016/j.jamcollsurg.2007.12.026.

Cangiarella J, Guth A, Axelrod D, Darvishian F, Singh B, Simsir A, Roses D, Mercado C. Is surgical excision necessary for the management of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed on core needle biopsy?: a report of 38 cases and review of the literature. Arch Pathol Lab Med. 2008 Jun;132(6):979-83. Cited in Pubmed; PMID 18517282.

Gralow JR, Burstein HJ, Wood W, Hortobagyi GN, Gianni L, von Minckwitz G, Buzdar AU, Smith IE, Symmans WF, Singh B, Winer EP. Preoperative therapy in invasive breast cancer: pathologic assessment and systemic therapy issues in operable disease. J Clin Oncol. 2008 Feb 10;26(5):814-9. Cited in Pubmed; PMID 18258991. doi: 10.1200/JCO.2007.15.3510.

Laser J, Cangiarella J, Singh B, Melamed J, Chiriboga L, Yee H, Darvishian F. Invasive lobular carcinoma of the breast: role of endothelial lymphatic marker D2-40. Ann Clin Lab Sci. 2008;Spring 38(2):99-104. Cited in Pubmed; PMID 18469353.

Martin MB, Reiter R, Johnson M, Shah MS, Iann MC, Singh B, Richards JK, Wang A, Stoica A. Effects of tobacco smoke condensate on estrogen receptor-alpha gene expression and activity. Endocrinology. 2007 Oct;148(10):4676-86. Epub 2007 Jul 19. Cited in Pubmed; PMID 17640996. doi: 10.1210/en.2007-0208.

Xie B, Freudenheim JL, Cummings SS, Singh B, He H, McCann SE, Moysich KB, Shields PG. Accurate genotyping from paraffin-embedded normal tissue adjacent to breast cancer. Carcinogenesis. 2006 Feb;27(2):307-10. Epub 2005 Aug 19. Cited in Pubmed; PMID 16113052. doi: 10.1093/carcin/bgi215.

Zhu Y, Singh B, Hewitt S, Liu A, Gomez B, Wang A, Clarke R. Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays. Int J Oncol. 2006 Jan;28(1):67–76. Cited in Pubmed; PMID 16327981.

Singh B. Pathology Issues Related to Neoadjuvant Treatment and the Evaluation of Pathological Response. Seminars in Breast Disease. 2005;8:77.

Moroni M, Soldatenkov V, Zhang L, Zhang Y, Stoica G, Gehan E, Rashidi B, Singh B, Ozdemirli M, Mueller SC. Progressive loss of Syk and abnormal proliferation in breast cancer cells. Cancer Res. 2004 Oct 15;64(20):7346–54. Cited in Pubmed; PMID 15492255.

Blancato J, Singh B, Liu A, Liao DJ, Dickson RB. Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses. Br J Cancer. 2004 Apr 19;90(8):1612–9. Cited in Pubmed; PMID 15083194.

Isaacs C, Cavalli LR, Cohen Y, Pennanen M, Shankar LK, Freedman M, Singh B, Liu M, Gallagher A, Rone JD, Dickson RB, Sidransky D, Haddad BR. Detection of LOH and mitochondrial DNA alterations in ductal lavage and nipple aspirate fluids from hngh-risk patients. Breast Cancer Res Treat. 2004 Mar;84(2):99–105. Cited in Pubmed; PMID 14999140.

Cotarla I, Ren S, Zhang Y, Gehan E, Singh B, Furth PA. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer. 2004 Feb 20;108(5):665–71. Cited in Pubmed; PMID 14696092.

Ellis MJ, Coop A, Singh B, Tao Y, Llombart-Cussac A, Janicke F, Mauriac L, Quebe-Fehling E, Chaudri-Ross HA, Evans DB, Miller WR. Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status. Cancer Res. 2003 Oct 1;63(19):6523–31.

Ellis MJ, Coop A, Singh B, Mauriac L, Llombert-Cussac A, Janicke F, Miller WR, Evans DB, Dugan M, Brady C, Quebe-Fehling E, Borgs M. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB1 and/or ErbB2 positive, estrogen receptor positive primary breast cancer: Evidence from a phase 3 randomized trial. J of Clinical Oncology. 2001 Sep 15;19(18):3808–16.

Selected Books

Singh B. Pathology of Breast Disorders. In: Principles of Breast Surgery: Principles and Art. Philadelphia: Lippincott Williams and Wilkins; 2006. pp. 66–82.

Organizational Associations

Cancer and Leukemia Group B; United States and Canadian Academy of Pathology; American Association of Cancer Research; American Society of Breast Disease; New York Metropolitan Breast Cancer Group

Selected Awards

2002 Nomination, Golden Apple, Georgetown University Medical School
1988 Best Graduate, Rohtak Medical College, Rohtak, Haryana, India

Hospital Affiliations

Tisch Hospital