Research and Clinical Interests
The lipid sphingosine-1-phosphate (S1P) plays critical roles in the immune system and vascular development. S1P is an indispensable guidance cue for lymphocyte migration and may promote inflammation. Furthermore, mice that cannot produce S1P die of hemorrhage at mid-gestation and S1P may support angiogenesis in adults. Despite its importance, we understand little about how production and distribution of S1P are regulated. We are investigating how S1P levels are set and how it affects immunity.
Bréart B, Ramos-Perez WD, Mendoza A, Salous AK, Gobert M, Huang Y, Adams RH, Lafaille JJ, Escalante-Alcalde D, Morris AJ, Schwab SR. Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med. 2011 Jun 6;208(6):1267-78. Cited in Pubmed; PMID 21576386. doi: 10.1084/jem.20102551.
Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18;207(1):17-27. Cited in Pubmed; PMID 20026661. doi: 10.1084/jem.20091619. PMCID: PMC2812554.
Schwab SR, Cyster JG. Finding a way out: Lymphocyte egress from lymphoid organs [review]. Nat Immunol. 2007 Dec;8(12):1295-301. Cited in Pubmed; PMID 18026082. doi: 10.1038/ni1545.
Pappu R*, Schwab SR*, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13;316(5822):295-8. Cited in Pubmed; PMID 17363629.
Shastri N, Cardinaud S, Schwab SR, Serwold T, Kunisawa J. All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen-processing pathway. Immunol Rev. 2005 Oct;207:31-41. Cited in Pubmed; PMID 16181325.
Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 9;309(5741):1735-9. Cited in Pubmed; PMID 16151014.
Schwab SR, Shugart JA, Horng T, Malarkannan S, Shastri N. Unanticipated antigens: translation initiation at CUG with leucine. PLoS Biol. 2004 Nov;2(11):e366. Cited in Pubmed; PMID 15510226.
Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, Cyster JG. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity. 2004 Apr;20(4):441-53. Cited in Pubmed; PMID 15084273.
Schwab SR, Li KC, Kang C, Shastri N. Constitutive display of cryptic translation products by MHC class I molecules. Science. 2003 Sep 5;301(5638):1367-71. Cited in Pubmed; PMID 12958358.
Shastri N, Schwab S, Serwold T. Producing nature’s gene-chips: the generation of peptides for display by MHC class I molecules. Annu Rev Immunol. 2002;20:463-93. Cited in Pubmed; PMID 11861610.
Malarkannan S, Horng T, Shih PP, Schwab S, Shastri N. Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. Immunity. 1999 Jun;10(6):681-90. Cited in Pubmed; PMID 10403643.
2010 Pew Scholar in the Biomedical Sciences
2007 Biochemical Journal Young Investigator Award
2007 Irvington Institute for Immunological Research Senior Postdoctoral Fellowship
2004 Damon Runyon Cancer Research Foundation Postdoctoral Fellowship
2001 Teaching Effectiveness Award (University of California Berkeley)
2001 Outstanding Graduate Instructor Award (University of California Berkeley)
1997 National Science Foundation Graduate Research Fellowship
1992 Herchel Smith Harvard Scholarship
1992 Tocqueville Prize
1992 Hoopes Prize
1991 AB summa cum laude Harvard University
1991 Phi Beta Kappa Junior Twelve (Harvard)