Research and Clinical Interests
We study the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work identified and characterized SEK1/MKK4, the first known activator for the SAPK/JNK enzyme. We are now focusing on ERK3/MAPK6. ERK3 is enriched in the developing nervous system and is restricted to vertebrates. To dissect the regulation and function of ERK3, we are employing a multidisciplinary approach which includes biochemistry, genomics and cell biology.
Tsikitis M, Acosta-Alvear D, Blais A, Campos EI, Lane WS, Sánchez I, Dynlacht BD. Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis. EMBO Rep. 2010 Oct;Cited in Pubmed; PMID 20948544. doi: 10.1038/embor.2010.154.
Tsang WY*, Spektor A*, Vijayakumar S, Bista BR, Sanchez I, Duensing S, Dynlacht BD. Cep76, a Centrosomal Protein that Specifically Restrains Centriole Reduplication. Dev Cell. 2009 May 19;16(5):649–60. doi: 10.1016/j.devcel.2009.03.004.
Tsang WY, Wang L, Chen Z, Sánchez I, Dynlacht BD. SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression. J Cell Biol. 2007 Aug 13;178(4):621-33.
Tsang WY, Spektor A, Luciano DJ, Indjeian VB, Chen Z, Salisbury JL, Sánchez I, Dynlacht BD. CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability. Mol Bio Cell. 2006 Aug;17(8):3423-34.
Sánchez I, Dynlacht BD. New insights into cyclins, CDKs, and cell cycle control. Semin Cell Dev Biol. 2005 Jun;16(3):311-21.
Bind E, Kleyner Y, Skowronska-Krawczyk D, Bien E, Dynlacht BD, Sánchez I. A novel mechanism for mitogen-activated protein kinase localization. Mol Bio Cell. 2004 Oct;15(10):4457-66.
Kuroki DW, Minden A, Sánchez I, Wattenberg EV. Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway. J Biol Chem. 1997 Sep 19;272(38):23905-11.
Woo MS, Sánchez I, Dynlacht BD. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol Cell Biol. 1997 Jul;17(7):3566–79.
Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sánchez I. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3302-3307.
Sánchez I, Dynlacht BD. Transcriptional control of the cell cycle. Curr Opin Cell Biol. 1996 Jun;8(3):318–24.
Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995 Oct 26;377(6551):750–4.
Sánchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22;372(6508):794–8.
Sánchez I, Goya L, Vallerga AK, Firestone GL. Glucocorticoids reversibly arrest rat hepatoma cell growth by inducing an early G1 block in cell cycle progression. Cell Growth Differ. 1993 Mar;4(3):215–25.
Israel Cancer Research Fund Study Section
Ad Hoc Member, NCI Subcommittee I (Career Development)