Irma Sánchez, Ph.D.
Assistant Professor of Pathology
Molecular Oncology / MAPK signal transduction and cell biology of the centrosome
sanchi01@nyumc.org, (212) 263 6162
Fax: (212) 263 6157
522 First Avenue, SRB 1110, New York, NY 10016
Research and Clinical Interests
We study the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work identified and characterized SEK1/MKK4, the first known activator for the SAPK/JNK enzyme. We are now focusing on ERK3/MAPK6. ERK3 is enriched in the developing nervous system and is restricted to vertebrates. To dissect the regulation and function of ERK3, we are employing a multidisciplinary approach which includes biochemistry, genomics and cell biology.
Selected Publications
Tsang WY, Wang L, Chen Z, Sánchez I, Dynlacht BD. SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression. J Cell Biol. 2007 Aug 13;178(4):621-33.
Tsang WY, Spektor A, Luciano DJ, Indjeian VB, Chen Z, Salisbury JL, Sánchez I, Dynlacht BD. CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability. Mol Bio Cell. 2006 Aug;17(8):3423-34.
Sánchez I, Dynlacht BD. New insights into cyclins, CDKs, and cell cycle control. Semin Cell Dev Biol. 2005 Jun;16(3):311-21.
Bind E, Kleyner Y, Skowronska-Krawczyk D, Bien E, Dynlacht BD, Sánchez I. A novel mechanism for mitogen-activated protein kinase localization. Mol Bio Cell. 2004 Oct;15(10):4457-66.
Kuroki DW, Minden A, Sánchez I, Wattenberg EV. Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway. J Biol Chem. 1997 Sep 19;272(38):23905-11.
Woo MS, Sánchez I, Dynlacht BD. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol Cell Biol. 1997 Jul;17(7):3566–79.
Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sánchez I. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3302-3307.
Sánchez I, Dynlacht BD. Transcriptional control of the cell cycle. Curr Opin Cell Biol. 1996 Jun;8(3):318–24.
Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995 Oct 26;377(6551):750–4.
Sánchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22;372(6508):794–8.
Sánchez I, Goya L, Vallerga AK, Firestone GL. Glucocorticoids reversibly arrest rat hepatoma cell growth by inducing an early G1 block in cell cycle progression. Cell Growth Differ. 1993 Mar;4(3):215–25.
