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Research and Clinical Interests

I'm currently studying the structural correlates of mouse IgA allotypes. In BALB/c mouse IgA, light (L) and heavy (H) chains are not covalently bound, as they are in other strains. I have shown that covalent binding of L chains to IgA H chains depends upon variable "extra" Cys residues present in the hinge regions of IgA from other strains. I am now investigating the contribution of amino acid differences amongst the IgA allotypes to epitopes recognized by anti-allotypic monoclonal antibodies.

Selected Publications

Lamm ME, Phillips-Quagliata JM. Commentary: Origin and homing of intestinal IgA antibody-secreting cells. J. Exp. Med. 2002;195:1-3.

Phillips-Quagliata JM. Mouse IgA allotypes have major differences in their hinge regions. Immunogenetics. 2002;53:1033–38.

Phillips-Quagliata JM, Faria AMC, Han J, Spencer DH, Haughton G, Casali P. IgG2a and IgA co-expression by the natural autoantibody-producing murine B lymphoma, T560. Autoimmunity. 2001;33:181-97.

Phillips-Quagliata JM, Patel S, Han J-K, Arakelov S, Dharma Rao T, Shulman MJ, Fazel S, Corley RB, Everett M, Klein MH, Underdown BJ, Corthésy B. The IgA/IgM receptor expressed on a murine B cell lymphoma is poly-Ig receptor. J Immunol. 2000;165:2544-55.

Phillips-Quagliata JM, Rao TD, Maghazachi AA, Faria, AMC, Basch RS. The IgA receptors of T560, a murine Il-4-secreting, CD5-, IgG2ak+, BrMRBC-binding B lymphoma. Ann NY Acad Sci. 1992;651:491-3.

Rao TD, Maghazachi AA, Faria, AMC, Basch RS, Phillips-Quagliata JM. T560: an (H-2b X H-2a) F1 hybrid, phosphorylcholine (PC)-binding, murine B cell lymphoma that bears receptors for IgA and IgG, presents antigen and secretes IL-4. Internat Immunol. 1992;3:107-18.

Selected Books

Phillips-Quagliata JM. Adhesion molecules and circulation and differentiation of lymphocytes in GALT and mammary glands. Chapter 3. In: Brostoff J, Challacombe SJ, editors. Food Allergy and Intolerance. 2nd edition. London, New York: W.B. Saunders; 2002. pp. 37–50.

Faria AMC, Rao TD, Phillips-Quagliata JM. A new IgA receptor expressed on a highly activated murine B cell lymphoma. In: Mestecky J, editor. Adv in Mucosal Immunol. Vol. A. New York: J Plenum Press; 1995. pp. 663–8.

Phillips-Quagliata JM, Lamm ME. Lymphocyte homing to mucosal effector sites. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J, editors. Mucosal Immunology, Vol. 1. San Diego: Academic Press; 1994. pp. 225–39.

Organizational Associations

American Association of Immunologists. Chairperson of Committee on the Status of Women in Immunology (1976-1979). Nominations committee (1990-1991); American Association of Pathologists; British Society for Immunology; Harvey Society; New York Academy of Sciences; Society for Mucosal Immunology.

Selected Awards

British Egg Marketing Board Scholarship (1959-1962)
NIH Research Career Development Award (1973-1978)
Third International Congress of Immunology in Sydney, Australia (1977) - American Association of Immunologists Travel Bursary.

© 2008 NYU Department of Pathology