Jennifer A. Philips, M.D., Ph.D.
Assistant Professor of Medicine and Pathology
Department of Medicine, Division of Infectious Diseases and Immunology
Immunology, Pathobiology / Tuberculosis, Host Pathogen Interactions, Innate Immunity, Bacterial Pathogenesis
Jennifer.Philips@nyumc.org, (212) 263 9181
Fax: (212) 263 9230
522 First Avenue, SRB 907G, New York, NY 10016
Research and Clinical Interests
My laboratory is interested in how Mycobacterium tuberculosis evades eradication by the host. M.tb targets conserved molecules to survive within macrophages, cells that normally eradicate bacteria. Using RNAi, we employ genome-wide, high throughput strategies to identify host factors that influence the outcome of infection in model systems and mammalian macrophages. Our goal is to characterize how these factors intersect bacterial virulence strategies and impact the outcome of infection. Post-doctoral positions are available for highly motivated individuals interested in mycobacterial pathogenesis and host pathogen interactions.
Selected Publications
Philips JA. Mycobacterial manipulation of vacuolar sorting. Cell Microbiol. 2008 Dec;10(12):2408-15. Cited in Pubmed; PMID 18783482. doi: 10.1111/j.1462-5822.2008.01239.x.
Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3070-5. Epub 2008 Feb 19. Cited in Pubmed; PMID 18287038. doi: 10.1073/pnas.0707206105. PMCID: PMC2268586.
Philips JA, Marty FM, Stone RM, Koplan BA, Katz JT, Baden LR. Torsades de pointes associated with voriconazole use. Transpl Infect Dis. 2007 Mar;9(1):33-6. Cited in Pubmed; PMID 17313469. doi: 10.1111/j.1399-3062.2006.00160.x.
Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science. 2005 Aug 19;309(5738):1251-3. Epub 2005 Jul 14. Cited in Pubmed; PMID 16020694. doi: 10.1126/science.1116006.
Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 2005 Aug 19;309(5738):1248-51. Epub 2005 Jul 14. Cited in Pubmed; PMID 16020693. doi: 10.1126/science.1116008.
Philips J, Herskowitz I. Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. J Cell Biol. 1998 Oct 19;143(2):375-89. Cited in Pubmed; PMID 9786949. PMCID: PMC2132843.
Philips J, Herskowitz I. Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae. J Cell Biol. 1997 Sep 8;138(5):961-74. Cited in Pubmed; PMID 9281576. PMCID: PMC2136759.
Wasilewski MM, Lim KC, Philips J, McKerrow JH. Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo. Mol Biochem Parasitol. 1996 Oct 30;81(2):179-89. Cited in Pubmed; PMID 8898333. doi: 10.1016/0166-6851(96)02703-X.
Dernburg AF, Broman KW, Fung JC, Marshall WF, Philips J, Agard DA, Sedat JW. Perturbation of nuclear architecture by long-distance chromosome interactions. Cell. 1996 May 31;85(5):745-59. Cited in Pubmed; PMID 8646782. doi: 10.1016/S0092-8674(00)81240-4.
Condon C, Philips J, Fu ZY, Squires C, Squires CL. Comparison of the expression of the seven ribosomal RNA operons in Escherichia coli. EMBO J. 1992 Nov;11(11):4175-85. Cited in Pubmed; PMID 1396599. PMCID: PMC556928.
Selected Awards
2008 Maxwell Finland Award for Excellence in Research, Massachusetts Infectious Disease Society
1997 Krevans Research Fellowship, UCSF
1991 summa cum laude, Columbia University
1990 Phi Beta Kappa, elected junior year, Columbia University
