Research and Clinical Interests

The interests of the lab are the molecular bases of cancer studying oncogenes and tumor suppressor genes. In particular the analysis of the Ras oncogenes in tumorigenesis and physiology using animal models and other molecular and biological approaches to determine their function and to identify mechanisms to block their effects.

Selected Publications

Martello LA, Pellicer A. Biochemical and biological analyses of Rgr RalGEF oncogene. Methods in Enzymology. 2006;407:115-128. Cited in Pubmed; PMID 16757319.

Perez de Castro I, Benet M, Jimenez M, Alzabin S, Malumbres M, Pellicer A. Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res. 2005;65:3249-56. Cited in Pubmed; PMID 15833857.

Diaz Perez de Castro I, Bivona T, Philips M, Pellicer A. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol. 2004;24:3485-96. Cited in Pubmed; PMID 15060167.

Tseng JC, Levin B, Hurtado A, Yee H, Perez de Castro I, Jimenez M, Shamamian P, Jin R, Novick RP, Pellicer A, Meruelo D. Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol. 2004 Jan;22(1):70-7. Epub 2003 Nov 30. Cited in Pubmed; PMID 14647305.

Perez de Castro I, Diaz R, Malumbres M, Hernandez MI, Jagirdar J, Jimenez J, Ahn D, Pellicer A. Mice deficient for N-ras: Impaired antiviral immune response and T-cell function. Cancer Res. 2003;63:1615-22. Cited in Pubmed; PMID 12670913.

Bivona T, Perez de Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen P, Pellicer A, Cox AD, Philips MR. PLCγ activates Ras on Golgi via RasGRP1. Nature. 2003;424:694-8. Cited in Pubmed; PMID 12845332.

Diaz R, Ahn D, Lopez-Barcons Ll, Malumbres M, Perez de Castro I, Lue J, Ferrer-Miralles N, Mangues R, Tsong J, Garcia R, Perez-Soler R, Pellicer A. The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res. 2002;62:4514-8. Cited in Pubmed; PMID 12154063.

Leonardi P, Kassin E, Hernandez-Munoz I, Diaz R, Inghirami G, Pellicer A. Human rgr: Transforming activity and alteration in T-cell malignancies. Oncogene. Oncogene. 2002;21:5108-16. Cited in Pubmed; PMID 12140761.

Mangues R, Corral T, Kohl NE, Symmans WF, Lu S, Malumbres M, Gibbs JB, Oliff A, Pellicer A. Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. Cancer Res. 1998;58:1253-9. Cited in Pubmed; PMID 9515813.

D’Adamo D, Novick S, Kahn JM, Leonardi P, Pellicer A. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. Oncogene. 1997;14:1295-1306. Cited in Pubmed; PMID 9178890.

Umanoff H, Edelmann W, Pellicer A, Kucherlapati R. The murine N-ras gene is not essential for development. Proc Natl Acad Sci U S A. 1995;92:1709-13. Cited in Pubmed; PMID 7878045.

Mangues R, Seidman I, Pellicer A, Gordon JW. Tumorigenesis and male sterility in transgenic mice expressing an MMTV/N-ras oncogene. Oncogene. 1990;5:1491-7. Cited in Pubmed; PMID 2174525.

Corominas M, Kamino H, Leon J, Pellicer A. Oncogene activation in human benign tumors of the skin (keratoacanthomas): Is HRAS involved in differentiation as well as proliferation? Proc Natl Acad Sci U S A. 1989;86:6372-6. Cited in Pubmed; PMID 2668964.

Guerrero I, Calzada P, Mayer A, Pellicer A. A molecular approach to leukemogenesis: Mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci U S A. 1984;81:202-205. Cited in Pubmed; PMID 6582476.

Wigler M, Pellicer A, Silverstein S, Axel R. Transfer of single copy eukaryotic genes using total cellular DNA as donor. Cell. 1978;14:725-31. Cited in Pubmed; PMID 210957.

Selected Books

Leon J, Pellicer A. ras genes involvement in carcinogenesis: Lessons from animal model systems. In: Lacal JC, McCormick F, editors. The ras superfamily of GTPases. Boca Raton: CRC Press; 1993. pp. 3-36.

Pellicer A. Gene Purification by Transfection Methods. In: Kucherlapati R, editor. Gene transfer. New York: Plenum Press; 1986. pp. 263-288.

Wigler M, Pellicer A, Axel R, Silverstein S. Transformation of Mammalian Cells. In: Setlow JK, Hollaender A, editors. Genetic Engineering, Vol. 1. New York: Plenum Press; 1979. pp. 51-72.

Organizational Associations

American Association for Cancer Research; American Association for Microbiology

Selected Awards

Irma Hirschl-Monique Weill-Caulier Faculty Award (1981)
Leukemia Society Scholarship (1986)
Member of the International Academy of Oncology (1991)
NIH Merit Awardee (1992-98)
Doctoral Honorary Degree by Universitat Rovira i Virgili, Spain (1997)