Zhiheng Pei, M.D., Ph.D.
Assistant Professor of Pathology and Medicine
Pathobiology, Surgical Pathology / Bacteria microbiome inflammation esophagus tonsils
Zhiheng.Pei@nyumc.org, (212) 951 5492
423 East 23rd Street, VET 6001W, New York, NY 10016
Foregut Microbiome in the Development of Esophageal Adenocarcinoma
Research and Clinical Interests
My research interests are primarily in microbial ecological diseases, an emerging concept that attributes the cause of some idiopathic diseases to the alteration of commensal microbiota. One project in my laboratory explores the role of bacterial biota in the development of esophageal adenocarcinoma in reflux-related disorders (UH2CA140233). Another project relates to the role of bacterial metacolonies in the etiology of idiopathic tonsillar hypertrophy (R01AI063477).
Selected Publications
Chaudhry S, Lubitz S, Newman K, Pei ZH, Shepard T, Danoff A. Adenomatoid Tumor of the Adrenal Gland Case Report of a Rare Adrenal Lesion. Endocrinologist. 2009 Sep;19(5):233-6. doi: 10.1097/TEN.0b013e3181b5a01f.
Yang L, Lu X, Nossa CW, Francois F, Peek RM, Pei Z. Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology. 2009 Aug;137(2):588-97. Epub 2009 Apr 23. Cited in Pubmed; PMID 19394334. doi: 10.1053/j.gastro.2009.04.046.
Newman K, Stahl-Herz J, Kabiawu O, Newman E, Wieczorek R, Wang B, Pei Z, Bannan M, Lee P, Xu R. Pancreatic carcinoma with multilineage (acinar, neuroendocrine, and ductal) differentiation. Int J Clin Exp Pathol. 2009 Jun 20;2(6):602-7. Cited in Pubmed; PMID 19636408. PMCID: 2713457.
Pei A, Nossa CW, Chokshi P, Blaser MJ, Yang L, Rosmarin DM, Pei Z. Diversity of 23S rRNA genes within individual prokaryotic genomes. PLoS One. 2009;4(5):e5437. Epub 2009 May 5. Cited in Pubmed; PMID 19415112. doi: 10.1371/journal.pone.0005437. PMCID: 2672173.
Godoy-Vitorino F, Ley RE, Gao Z, Pei Z, Ortiz-Zuazaga H, Pericchi LR, Garcia-Amado MA, Michelangeli F, Blaser MJ, Gordon JI, Dominguez-Bello MG. Bacterial community in the crop of the hoatzin, a neotropical folivorous flying bird. Appl Environ Microbiol. 2008 Oct;74(19):5905-12. Epub 2008 Aug 8.
Roper J, Francois F, Shue PL, Mourad MS, Pei Z, Olivares de Perez AZ, Perez-Perez GI, Tseng CH, Blaser MJ. Leptin and ghrelin in relation to Helicobacter pylori status in adult males. J Clin Endocrinol Metab. 2008 Jun;93(6):2350-7. Epub 2008 Apr 8.
Gao Z, Tseng C-h, Strober BE, Pei Z, Blaser MJ. Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS ONE. 2008;3:e2719.
Francois F, Roper J, Goodman A, Pei Z, Ghumman M, Mourad M, Olivares de Perez AZ. Perez-Perez GI, Tseng C-H, Blaser MJ. The association of gastric leptin with esophageal inflammation and metaplasia. Gut. 2008;57:16-24.
Peng Y, Chiriboga L, Yee H, Pei Z, Wang Z, Lee P. Androgen receptor coactivator ARA70alpha and ARA70beta isoform-specific antibodies: new tools for studies of expression and immunohistochemical localization. Appl Immunohistochem Mol Morphol. 2008 Jan;16(1):7-12.
Ouyang J, Pei Z, Lutwick L, Dalal S, Yang L, Cassai N, Sandhu K, Hanna B, Wieczorek RL, Bluth M, Pincus MR. Paenibacillus thiaminolyticus: a new cause of human infections. Ann Clin Lab Sci. 2008;38(4):393-400.
Kong X, Zhao Y, Ksionsk M, Zhou M, Walden P, Bosland M, Pei Z, Lee P, Melamed J. Radiographic determination of tissue thickness in paraffin blocks: application to the construction of tissue microarrays. Appl Immunohistochem Mol Morphol. 2007 Mar;15(1):108-12.
Gao Z, Tseng CH, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2927-32.
Yang L, Pei Z. Bacteria, inflammation, and colon cancer. World J Gastroenterol. 2006 Nov 14;12(42):6741-6.
Pei Z, Yang L, Peek RM, Levine S, Pride DT, Blaser MJ. Bacterial biota in reflux esophagitis and Barrettos esophagus. World J Gastroenterol. 2005 Dec 14;11:7277-83.
Pei Z, Bini EJ, Yang L, Zhou M, Francois F, Blaser MJ. Bacterial biota in the human distal esophagus. Proc Natl Acad Sci U S A. 2004 Mar 23;101:4250-5.
Selected Reviews
Sefers S, Pei Z, Tang YW. False positives and false negatives encountered in diagnostic molecular microbiology. Rev Med Microbiol. 2005 Apr;16:59-67.
Levine SA, Tang YW, Pei Z. Recent advances in the rapid detection of Bacillus anthracis. Rev Med Microbiol. 2005;16:125-33.
Organizational Associations
American Society for Microbiology
Hospital Affiliations
VA Hospital
