David W. O'Neill, M.D.
Assistant Professor of Pathology
Director, NYU Cancer Institute Vaccine and Cell Therapy Facility
Core Labs / Immunotherapy, Vaccine, Dendritic Cell, Immune Monitoring, Ikaros
oneild02@nyumc.org, (212) 263 8046 , (212) 263 8035
Fax: (212) 263 0270
400 East 34th Street, Rusk 718, New York, NY 10016
Research and Clinical Interests
Dr. O’Neill is interested in immunotherapies for cancer and chronic infections such as HIV/AIDS. He directs the NYU Cancer Institute’s Vaccine and Cell Therapy Facility, which provides the infrastructure and expertise to produce dendritic cell and other vaccines for human trials, and to monitor patients’ responses to therapy. The laboratory is currently focused on a study to test the immunogenicity of dendritic cells compared to incomplete Freund’s adjuvant in vaccines for malignant melanoma.
Selected Publications
O'Neill DW, Bhardwaj N. Exploiting dendritic cells for active immunotherapy of cancer and chronic infections. Mol Biotechnol. 2007;36:131-141. Cited in Pubmed; PMID 17914192.
Velazquez EF, Yancovitz M, Pavlick A, Berman R, Shapiro R, Bogunovic D, O'Neill D, Yu YL, Spira J, Christos PJ, Zhou XK, Mazumdar M, Nanus DM, Liebes L, Bhardwaj N, Polsky D, Osman I. Clinical relevance of Neutral Endopeptidase (NEP/CD10) in melanoma. J Transl Med. 2007;5:2-11. Cited in Pubmed; PMID 17207277.
O’Neill DW, Bhardwaj N. Armed and ready: How effector T cells deploy in reactive lymph nodes to modulate immunity. Nature Immunol. 2007;8(7):679-81. Cited in Pubmed; PMID 17579644.
Velazquez EF, Jungbluth AA, Yancovitz M, Gnjatic S, Adams S, O'Neill D, Zavilevich K, Albukh T, Christos P, Mazumdar M, Pavlick A, Polsky D, Shapiro R, Berman R, Spira J, Busam K, Osman I, Bhardwaj N. Expression of the cancer/testis antigen NY-ESO-1 in primary and metastatic malignant melanoma (MM)--correlation with prognostic factors. Cancer Immun. 2007;7:11-17. Cited in Pubmed; PMID 17625806.
O’Neill DW, Adams S, Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood. 2004;104:2235-46. Cited in Pubmed; PMID 15231572.
Lopez RA, Schoetz S, DeAngelis K, O'Neill D, Bank A. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc Natl Acad Sci U S A. 2002;99:602-7. Cited in Pubmed; PMID 11805317.
O'Neill DW, Schoetz SS, Lopez RA, Castle M, Rabinowitz L, Shor E, Krawchuk D, Goll MG, Renz M, Seelig HP, Han S, Seong RH, Park SD, Agalioti T, Munshi N, Thanos D, Erdjument-Bromage H, Tempst P, Bank A. An Ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol. 2000;20:7572-82. Cited in Pubmed; PMID 11003653.
Xue H, O'Neill D, Morrow J, Bank A. A novel mouse gene, HemT, encoding an hematopoietic cell-specific transcript. Gene. 1999;231(1-2):49-58. Cited in Pubmed; PMID 10231568.
O'Neill D, Yang J, Erdjument-Bromage H, Bornschlegel K, Tempst P, Bank A. Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. Proc Natl Acad Sci U S A. 1999;96:349-54. Cited in Pubmed; PMID 9892636.
Xue H, O'Neill D, Wang X, Wolgemuth DJ, Bank A. HemT-3, an alternative transcript of mouse gene HemT specific to male germ cells. Gene. 1999;240:193-9. Cited in Pubmed; PMID 10564826.
Jackson, C. E., O’Neill, D. and Bank, A. Nuclear factor binding sites in human beta-globin IVS2. J Biol Chem. 1995;270:28448-56. Cited in Pubmed; PMID 7499351.
Castle M, O’Neill D, Bank A. In vitro transcription from the human A-gamma-globin gene promoter. Blood. 1993;82:1344-50. Cited in Pubmed; PMID 8353292.
O'Neill D, Bornschlegel K, Flamm M, Castle M, Bank A. A DNA-binding factor in adult hematopoietic cells interacts with a pyrimidine-rich domain upstream from the human delta-globin gene. Proc Natl Acad Sci U S A. 1991;88:8953-7. Cited in Pubmed; PMID 1717993.
O'Neill D, Kaysen J, Donovan-Peluso M, Castle M, Bank A. Protein-DNA interactions upstream from the human A-gamma-globin gene. Nucleic Acids Res. 1990;18:1977-82 . Cited in Pubmed; PMID 2336386.
Selected Books
O’Neill D, Bhardwaj N. Generation of autologous peptide- and protein-pulsed dendritic cells for patient-specific immunotherapy. In: Ludewig B, Hoffmann MW, editors. Adoptive Immunotherapy – Methods and Protocols Methods in Molecular Medicine. Totowa, NJ: Humana Press; 2005. pp. 97-112.
O’Neill DW, Bhardwaj N. Differentiation of peripheral blood monocytes into dendritic cells. In: Bierer BE, Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors. Current Protocols in Immunology. Hoboken, NJ: John Wiley & Sons; 2005. pp. 22F.4.1-22F.4.9.
Selected Awards
1988-1991 NIH National Research Service Award
1991-1993 Cooley's Anemia Foundation Fellowship
1993-1998 NIH Clinical Investigator Award
