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Research and Clinical Interests

Dr. Nyambi’s interest is to study the HIV-1 viral genetic diversity and evolution and how dual HIV-1 infection and virus recombination drives viral evolution. Another interest is the antigenic relatedness of diverse HIV-1 viruses, the evolution of these viruses and their implication in vaccine design. Our studies have shown that despite genetic differences of various subtype viruses they still share some common antigenic epitopes and that these epitopes could be used in defining HIV-1 serotypes.

Selected Publications

Powell RL, Konings FA, Nanfack A, Burda S, Urbanski MM, Saa D, Nyambi PN. Quasispecies analysis of novel HIV-1 recombinants of subtypes A and G reveals no similarity to the mosaic structure of CRF02_AG. J Med Virol. 2007;79:1270-85.

Gorny MK, Williams C, Volsky B, Revesz K, Wang XH, Burda S, Kimura T, Konings FA, Nadas A, Anyangwe CA, Nyambi P, Krachmarov C, Pinter A, Zolla-Pazner S. Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1. J Virol. 2006;80:6865-72.

Konings FA, Burda ST, Urbanski MM, Zhong P, Nadas A, Nyambi PN. Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02_AG (CRF02_AG) has a higher in vitro replicative capacity than its parental subtypes A and G. J Med Virol. 2006;78:523-34.

Kelly HR, Urbanski M, Burda S, Zhong P, Konings F, Nanfack J, Tongo M, Kinge T, Achkar J, Nyambi P. Neutralizing antibody patterns and viral escape in HIV-1 non-B subtype chronically infected treatment-naïve individuals. Hum Antibodies. 2005;14:89-99.

Konings FA, Nyambi PN. V118I substitution in the reverse transcriptase gene of HIV type 1 CRF02_AG strains infecting drug-naive individuals in Cameroon . AIDS Res Hum Retroviruses. 2004;20:673-8.

Konings FA, Zhong P, Agwara M, Agyingi L, Zekeng L, Achkar JM, Ewane L, Saa, Afane Ze E, Kinge T, Nyambi PN. Protease mutations in HIV-1 non-B strains infecting drug-naïve villagers of Cameroon. AIDS Res Hum Retroviruses. 2004;20:105-9.

Nadas A, Zhong P, Burda S, Zekeng L, Urbanski M, Gorny M, Zolla-Pazner S, Nyambi PN. Defining Human Immunodeficiency Virus (HIV) type 1 Immunotypes with Six Human Monoclonal Antibodies. AIDS Res Hum Retroviruses. 2004;20:55-65.

Burda ST, Konings FA, Williams CA, Anyangwe C, Nyambi PN. HIV-1 CRF09_cpx circulates in the North West Province of Cameroon where CRF02_AG infections predominate and recombinant strains are common. AIDS Res Hum Retroviruses. 2004;20:1358-63.

Achkar JM, Burda ST, Konings FA, Urbanski MM, Williams CA, Seifen D, Kahirimbanyi MN, Vogler M, Parta M, Lupatkin HC, Zolla-Pazner S, Nyambi PN. Infection With HIV Type 1 Group M Non-B Subtypes in Individuals Living in New York City. J Acquir Immune Defic Syndr. 2004;36:835-44.

Zhong P, Kang L, Pan Q, Konings F, Burda S, Ma L, Xue Y, Zheng X, Jin Z, Nyambi P. Identification and distribution of HIV type 1 genetic diversity and protease inhibitor resistance-associated mutations in Shanghai, P.R. China. J Acquir Immune Defic Syndr. 2003;34:91-101.

Zhong P, Burda S, Konings F, Urbanski M, Ma L, Zekeng L, Ewane L, Agyingi L, Agwara M, Saa, Afane ZE, Kinge T, Zolla-Pazner S, Nyambi P. Genetic and biological properties of HIV type 1 isolates prevalent in villagers of the Cameroon equatorial rain forests and grass fields: further evidence of broad HIV type 1 genetic diversity. AIDS Res Hum Retroviruses. 2003;19:1167-78.

Nyambi PN, Zekeng L, Kenfack H, Tongo M, Nanfack A, Nkombe I, Ndonko F, Shang J, Burda S, Mbah H, Agyingi L, Zhong P, Nadas A, Zolla-Pazner S, Marmor M. HIV infection in rural villages of Cameroon. J Acquir Immune Defic Syndr. 2002;31:506-13.

Nyambi PN, Heyndrickx L, Vereecken B, burda S, De Houwer K, Coppens S, Urbanski M, Williams C, Ndumbe P, Janssens W. Predominance of infection with HIV-1 circulating recombinant form CRF02_AG in major Cameroonian cities and towns. AIDS. 2002;16:295-6.

Zhong P, Burda S, Urbanski M, Kenfack H, Tongo M, Heyndrickx L, Nanfack A, Shang J, Agyingi L, Zolla-Pazner S, Zekeng L, Nyambi P. HIV type group M clades infecting subjects from rural villages in equatorial rain forests of Cameroon. J Acquir Immune Defic Syndr. 2002;31:495-505.

Organizational Associations

American Society for Microbiology; American Association of Immunologists

Selected Awards

1991-1992 Belgian Scientific Scholarship for M.S. Degree
1992-1996 The Belgian Scientific Research Fellowship for a Ph.D. Degree