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Research and Clinical Interests

Biology of Malaria Parasites and Vaccine Development. Identification of the protective mechanisms in rodent and human malaria. Identification of the key protective antigens and their stage-specificity.

Selected Publications

Kumar KA, Sano G, Boscardin S, Nussenzweig RS, Nussenzweig MC, Zavala F, Nussenzweig V. The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature. 2006 Dec 14;444(7121):937-40. Epub 2006 Dec 6. Cited in Pubmed; PMID 17151604.

Boscardin SB, Hafalla JCR, Masilamani RF, Kamphorst AO, Zebroski HA, Rai U, Morrot A, Zavala F, Steinman RM, Nussenzweig RS, Nussenzweig MC. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med. 2006;203:599-606.

Deng T, Barba-Spaeth G, Rai U, Nussenzweig V, Rice CM, Nussenzweig RS. Yellow Fever 17D as a vaccine vector for microbial CTL epitopes: Protection in a rodent malaria model. J. Exp. Med. 2005;201:201- 209.

Birkett A, Lyons K, Schmidt A, Boyd D, Oliveira GA, Siddique A, Nussenzweig RS, Calvo-Calle JM, Nardin EH. A modified hepatitis B virus core particle containing multiple epitopes of Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Inf Imm 70. 2002;70:6860-70.

Kublin JG, Lowitt MH, Hamilton RG, Oliveira GA, Nardin EH, Nussenzweig RS, Schmeckpeper BJ, Diggs CL, Bodison SA, Edelman R. Delayed-type hypersensitivity in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoites. Vaccine. 2002;20:1853-61.

Gonzalez-Aseguinolaza G, Nakaya Y, Molano A, Dy E, Esteban M, Rodriguez D, Rodriguez JR, Palese P, Garcia-Sastre A, Nussenzweig RS. Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii. J Virol. 2002;77:873-75.

Thathy V, Fujioka H, Gantt S, Nussenzweig RS, Nussenzweig V, Menard R. Levels of circumsporozoite protein in the Plasmodium oocysts determine sporozoite morphology. EMBO. 2002;21:1586-96.

Bonaldo MC, Garratt RC, Caufour PS, Freire MS, Rodrigues MM, Nussenzweig RS, Galler R. Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus. J Mol Biol. 2002;315:873-75.

Zavala F, Rodrigues M, Rodriguez D, Rodriguez JR, Nussenzweig RS, Esteban M. A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8+ T cells. Virology. 2001;280:155-159 .

Nardin EH, Calvo-Calle, JM, Oliveira GA, Nussenzweig RS, Schneider M, Tiercy JM, Loutan L, Hochstrasser D, Rose K. A totally synthetic polyoxime malaria vaccine containing P. falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types. J Immun. 2001;166:481-489.

Bruna-Romero O, Gonzalez-Aseguinolaza G, Hafalla J, Tsuji M, Nussenzweig RS. Complete, long lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same. Proc Natl Acad Sci. 2001;98:11491-11496.

Mota MM, Pradel G, Vanderberg JP, Hafalla JCR, Frevert U, Nussenzweig RS, Nussenzweig V, Rodriguez A. Migration of Plasmodium sporozoites through cells before infection. Science. 2001;291:141- 144.

Oliveira-Ferreira J, Miyahira Y, Layton GT, Savage N, Esteban M, Rodriguez D, Rodriguez JR, Nussenzweig RS, Zavala F. Immunogenicity of Ty-VLP bearing a CD8+ T cell epitope of the CS protein of P. yoelii enhanced memory response by boosting with recombinant vaccinia virus . Vaccine. 2000;18:1863-1869.

Nardin E, Zavala F, Nussenzweig V, Nussenzweig RS. Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials. Parassitologia. 1999;41:397-402.

Selected Books and Reviews

Saul A, Nussenzweig V, Nussenzweig RS. Rationale for Malaria Vaccine Development. In: Kaufmann SHE, editor. Novel Vaccination Strategies. Weinheim: Wiley-VCH Verlag; 2004. pp. 479-503.

Nardin EH, Nussenzweig RS. Vaccines against Malaria: Synthetic peptide vaccines against the sporozoite stage of Plasmodium. In: Levine M, Woodrow GC, Kaper JB, Cobon GS, editors. New Generation Vaccines. 2nd Edition. New York: Marcel Dekker; 1997. pp. 989-1007.

Nardin EH, Nussenzweig RS. T cell responses to pre-erythrocytic stages of malaria: Role in protection and vaccine development. Ann Rev Immun. 1993;11:687-727.

Nardin EH, Nussenzweig RS. falciparum circumsporozoite synthetic peptide vaccine. In: Woodrow GC, Levine MM, editors. New Generation Vaccines: The Molecular Approach. New York: Marcel Dekker; 1990. pp. 469-81.

Cochrane AH, Nardin EH, Nussenzweig RS. Immunization against sporozoites of malaria. In: Kreier JP, editor. Malaria in Man and Experimental Animals. New York: Academic Press; 1980. pp. 163-202.

Organizational Associations

Member, American Academy of Arts and Sciences; Honorary Life Member, Royal Society of Tropical Medicine; Member, American Society of Tropical Medicine and Parasitology

Selected Awards

2008 Albert B. Sabin Gold Medal Award
H. Aragao Prize and Medal from the University of Rio de Janeiro
Bristol- Myers Squibb "Freedom to Discover" Award for Distinguished Achievement in Infectious Diseases Research
Member, Brazilian Academy of Science
Member of the National Institutes of Health Blue Ribbon Panel for formulating research plan for Malaria Vaccine Development
President, Harvey Society
Member of the American Academy of Arts and Sciences
Merck Institute, Member, Board of Scientific Advisors
Foreign Corresponding Member of the Royal Academy of Medicine of Belgium
Denis Thienpont Prize, Royal Academy of Medicine of Belgium
Award of the Infectious Disease Society of America
Carlos Finlay Prize for Microbiology, UNESCO
Abraham Horwitz Award for Inter-American Health, Pan American Health Organization
Paul-Ehrlich and Ludwig Darmstaedter Prize, Frankfurt am Main, Germany
Bernhard-Nocht-Medal, Tropical Diseases, Hamburg, Germany
Designated "Outstanding Woman Scientist", AWIS, Metropolitan New York Chapter
Advisor, Panel on the Status of Biomedical Research and Related Technology for Tropical Diseases, Office of Technology Assessment, Congress of United States, Washington, DC
Lecturer, Harvey Society, "Immunoprophylaxis of malaria. Characterization of a protective parasite surface antigen"
Advisor, Scientific Program Committee, American Society of Tropical Medicine & Hygiene Meetings
Member, Alpha Omega, Delta Chapter of New York University School of Medicine
President, New York Society of Tropical Medicine
Member, NIH Study Section on Tropical Medicine and Parasitology