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Research and Clinical Interests

Dr. Newcomb has a longstanding interest in brain tumors and their underlying molecular pathogenesis driving tumor initiation and progression. Her lab is currently investigating the mechanism of action of anticancer drugs on glioma cell lines, using in vitro and in vivo assays. She has developed the pre-clinical GL261 glioma animal model that mimics the aggressive and invasive growth behavior of the human disease to screen novel treatment approaches to combat this invariably fatal cancer.

Selected Publications

Newcomb EW, Lukyanov Y, Schnee T, Esencay M, Fischer I, Hong D, Shao Y, Zagzag D. The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo. Anticancer Drugs. 2007 Sep;18(8):875-82. Cited in Pubmed; PMID 17667592.

Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest. 2006 Dec;86(12):1221-32. Epub 2006 Oct 30. Cited in Pubmed; PMID 17075581.

Newcomb EW, Demaria S, Lukyanov Y, Shao Y, Schnee T, Kawashima N, Lan L, Dewyngaert JK, Zagzag D, McBride WH, Formenti SC. The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas. Clin Cancer Res. 2006 Aug 1;12(15):4730-7. Cited in Pubmed; PMID 16899624.

Newcomb EW, Lukyanov Y, Schnee T, Ali MA, Lan L, Zagzag D. Noscapine inhibits hypoxia-mediated HIF-1alpha expression andangiogenesis in vitro: a novel function for an old drug. Int J Oncol. 2006 May;28(5):1121-30. Cited in Pubmed; PMID 16596228.

Newcomb EW, Lymberis SC, Lukyanov Y, Shao Y, Schnee T, Devitt M, Rosenstein BS, Zagzag D, Formenti SC. Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol. Cell Cycle. 2006 Jan;5(1):93-9. Epub 2006 Jan 25. Cited in Pubmed; PMID 16319534.

Fischer I, Gagner JP, Law M, Newcomb EW, Zagzag D. Angiogenesis in gliomas: biology and molecular pathophysiology [review]. Brain Pathol. 2005 Oct;15(4):297-310. Cited in Pubmed; PMID 16389942.

Gagner JP, Law M, Fischer I, Newcomb EW, Zagzag D. Angiogenesis in gliomas: imaging and experimental therapeutics [review]. Brain Pathol. 2005 Oct;15(4):342-63. Cited in Pubmed; PMID 16389946.

Newcomb EW, Ali MA, Schnee T, Lan L, Lukyanov Y, Fowkes M, Miller DC, Zagzag D. Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy. Neuro Oncol. 2005 Jul;7(3):225-35. Cited in Pubmed; PMID 16053697.

Zagzag D, Salnikow K, Chiriboga L, Yee H, Lan L, Ali MA, Garcia R, Demaria S, Newcomb EW. Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain. Lab Invest. 2005 Mar;85(3):328-41. Cited in Pubmed; PMID 15716863.

Nomura M, Nomura N, Newcomb EW, Lukyanov Y, Tamasdan C, Zagzag D. Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells. J Cell Physiol. 2004 Dec;201(3):374-84. Cited in Pubmed; PMID 15389545.

Newcomb EW, Ali MA, Schnee T, Lan L, Lukyanov Y, Fowkes M, Miller DC, Zagzag D. Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity. Anticancer Drugs. 2004 Jun;15(5):411-9. Cited in Pubmed; PMID 15166614.

Zagzag D, Nomura M, Friedlander DR, Blanco CY, Gagner JP, Nomura N, Newcomb EW. Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. Cell Physiol. 2003 Aug;196(2):394-402. Cited in Pubmed; PMID 12811834.

Newcomb EW, Tamasdan C, Entzminger Y, Alonso J, Friedlander D, Crisan D, Miller DC, Zagzag D. Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor. Cell Cycle. 2003 Jun;2(3):243-50. Cited in Pubmed; PMID 12734434.

Alonso M, Tamasdan C, Miller DC, Newcomb EW. Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations b. Mol Cancer Ther. 2003 Feb;2(2):139-50. Cited in Pubmed; PMID 1258903.

Newcomb EW, Tamasdan C, Entzminger Y, Arena E, Schnee T, Kim M, Crisan D, Lukyanov Y, Miller DC, Zagzag D. Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy. Cell Cycle. 2003 Feb;3(2):230-4. Cited in Pubmed; PMID 14712094.

Selected Books

Kleihues P, Burger PC, Collins P, Newcomb EW, Ohgaki H, Cavenee WK. Glioblastoma. In: Kleihues P, Cavenee WK, editors. Pathology and Genetics of Tumours of the Nervous System. Lyon: IARC Press; 2000. pp. 29-39.

Cavenee, WK, Furnati, FB, Nagane M, Huang H. JS, Newcomb EW, Bigner DD, Weller M, Berens ME, Plate KH, Israel MA, Noble MD, Kleihues P. Diffusely infiltrating astrocytomas. In: Kleihues P, Cavenee WK, editors. Pathology and Genetics of Tumours of the Nervous System. Lyon: IARC Press; 2000. pp. 10-21.

Cavenee, WK, Bigner DD, Newcomb EW, Paulus W, Kleihues PK. Diffuse astrocytomas. In: Kleihues P, Cavenee WK, editors. Pathology and Genetics of Tumours of the Nervous System. Lyon: IARC Press; 1997. pp. 2-9.

Newcomb EW, Lang FF, Koslow M. The molecular biology of brain tumors. In: Tindall GT, Cooper PR, Barron DL, editors. The Practice of Neurosurgery. Baltimore: Williams & Wilkinson; 1996. pp. 477-493.

Organizational Associations

American Association for the Advancement of Science; New York Academy of Sciences; American Association for Cancer Research; American Society for Investigative Pathology; Society for Neuro Oncology; Member, Women in Cancer Research (WICR); AACR-WICR Brigid G. Leventhal Scholar Award Committee; Member, Weil Graduate School Alumni Committee; Anti-Cancer Drugs, Molecular Cancer Therapeutics

Selected Awards

1985-1987 New Investigator Award-NIH
1987-1995 First Award NIH
1994 Sanford C. Bernstein Foundation Award
1994-1995 Wendy Will Case Fund Award
1994-1997 The Brain Tumor Society Award
1995-2001 The Elsa U. Pardee Foundation Award
1999-2000 The National Brain Tumor Society Award
1999-2002 The Children's Brain Tumor Foundation Award
2000-2001 NCI Development Award
2000-2003 The James McDonnell Foundation Award

 

© 2008 NYU Department of Pathology