Patricia K. A. Mongini, Ph.D.
Associate Professor of Pathology
Associate Investigator, Laboratory of Experimental Immunology, The Feinstein Institute for Medical Research
B lymphocytes, COX-2, PGE2, Innate Immunity, Autoimmunity, CLL, Human
Research and Clinical Interests
Dr. Mongini has a long-standing interest in examining how human B cell function is regulated through receptors for antigen and innate immune system-derived co-stimuli. Her present studies focus on mechanisms whereby BAFF- and APRIL-promoted COX-2/PGE2 expression in B lymphocytes contributes to autoimmunity and to the pathogenesis of CLL.
Selected Publications
Mongini PK. COX-2 expression in B lymphocytes: Links to vaccines, inflammation and malignancy. Clin Immunol. 2007 Nov;125(2):117-119. Epub 2007 Sep 14. Cited in Pubmed; PMID 17869184.
Mongini PK, Inman JK, Han H, Fattah RJ, Abramson SB, Attur M. APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2. J Immunol. 2006 Jun 1;176(11):6736-51. Cited in Pubmed; PMID 16709833.
Mongini PK, Inman JK, Han H, Kalled SL, Fattah RJ, McCormick S. Innate immunity and human B cell clonal expansion: effects on the recirculating B2 subpopulation. J Immunol. 2005 Nov 1;175(9):6143-54. Cited in Pubmed; PMID 16237111.
Mongini PK, Jackson AE, Tolani S, Fattah RJ, Inman JK. Role of complement-binding CD21/CD19/CD81 in enhancing human B cell protection from Fas-mediated apoptosis. J Immunol. 2003 Nov 15;171(10):Cited in Pubmed; PMID 14607925.
Mongini PK, Tolani S, Fattah RJ, Inman JK. Antigen receptor triggered upregulation of CD86 and CD80 in human B cells: augmenting role of the CD21/CD19 co-stimulatory complex and IL-4. Cell Immunol. 2002 Apr;216(1-2):50-64. Cited in Pubmed; PMID 12381350.
Mongini PK, Inman JK. Cytokine dependency of human B cell cycle progression elicited by ligands which coengage BCR and the CD21/CD19/CD81 costimulatory complex. Cell Immunol. 2001 Feb 1;207(2):127-40. Cited in Pubmed; PMID 11243702.
Mongini PK, Liu Q, Vilensky MA, Highet PF, Inman JK. Evidence for an upper affinity threshold for anti-IgM-induced apoptosis in a human B-cell lymphoma.. Blood. 1998 Nov 15;92(10):3756-71. Cited in Pubmed; PMID 9808570.
Mongini PK, Vilensky MA, Highet PF, Inman JK. Membrane IgM-stimulated human B lymphocytes succumb to activation-related apoptosis at a G1-->S transition: influence of ligand affinity and valency. Cell Immunol. 1998 Sep 15;188(2):137-50. Cited in Pubmed; PMID 9756644.
Mongini PK, Vilensky MA, Highet PF, Inman JK. The affinity threshold for human B cell activation via the antigen receptor complex is reduced upon co-ligation of the antigen receptor with CD21 (CR2). J Immunol. 1997 Oct 15;159(8):3782-91. Cited in Pubmed; PMID 9378965.
Mongini PK, Blessinger CA, Highet PF, Inman JK. Membrane IgM-mediated signaling of human B cells. Effect of increased ligand binding site valency on the affinity and concentration requirements for inducing diverse stages of activation. J Immunol. 1992 Jun 15;148(12):3892-3901. Cited in Pubmed; PMID 1376344.
Mongini PK, Blessinger CA, Dalton JP. Affinity requirements for induction of sequential phases of human B cell activation by membrane IgM-cross-linking ligands. J Immunol. 1991 Mar 15;146(6):1791-800. Cited in Pubmed; PMID 2005379.
Rudich SM, Roux KH, Winchester RJ, Mongini PK. Anti-IgM-mediated B cell signaling. Molecular analysis of ligand binding requisites for human B cell clonal expansion and tolerance. J Exp Med. 1988 Jul 1;168(1):247-66. Cited in Pubmed; PMID 2456368.
Rudich SM, Mihaesco E, Winchester R, Mongini PK. Analysis of the domain specificity of various murine anti-human IgM monoclonal antibodies differing in human B lymphocyte signaling activity. Mol Immunol. 1987 Aug;24(8):809-20. Cited in Pubmed; PMID 2443845.
Rudich SM, Winchester R, Mongini PK. Human B cell activation. Evidence for diverse signals provided by various monoclonal anti-IgM antibodies. J Exp Med. 1985 Oct 1;62(4):1236-55. Cited in Pubmed; PMID 2413155.
Mongini P, Friedman S, Wortis H. Accessory cell requirement for anti-IgM-induced proliferation of B lymphocytes. Nature. 1978 Dec 14;276(5689):709-11. Cited in Pubmed; PMID 310516.
Selected Books
Mongini PKA, Blessinger C. Use of a solid-phase 3H-radioimmunoassay for the measurement of immunoglobulin produced in short term cultures of murine and human antibody secreting cells. In: Langone JJ, Van Vunakis, H, editors. Methods in Enzymology. Immunochemical Techniques. Vol 121. New York: Academic Press, Inc; 1986. pp. 438-453.
Mongini PKA, Paul WE. T cell regulation of B cell IgG subclass response to TNP-Ficoll. . In: Klinman N, et al, editors. Developments in Immunology. B lymphocytes in the immune response: Functional, developmental, and interactive properties. Vol 15. New York: Elsevier/North Holland Biomedical Press; 1981. pp. 369.
Mond JJ, Cossman J, Trost L, Hansen CT, Mongini PKA, Kessler S, Scher I, Paul WE. Profound immunologic abnormalities of mice expressing both the xid and nu genes. In: Seligmann M, Hitzig WH, editors. Primary immunodeficiencies. New York: Elsevier/North Holland Biomedical Press; 1980. pp. 165.
Organizational Associations
American Association of Immunologists; American Association for the Advancement of Science
Selected Awards
Sjogren's Foundation Innovative Concept Grant Award (2006-2007)
American Association of Immunologists Travel Awards (1980, 1983)
Frances L. Kallman Award (Stanford University, 1976)
