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Research and Clinical Interests

Dr. Melamed's clinical and research interests are in Uropathology. He directs the prostate cancer tissue bioresource at NYU, and focuses his research on studies of new markers on human tissue, using tissue microarrays. His interest is in early pathogenesis of prostate cancer and in diagnostic modalities that assist in surgical pathology. Additionally, he is interested in quality assurance and improvement measures in surgical pathology.

Selected Publications

Peng Y, Chen F, Melamed J, Chiriboga L, Wei J, Kong X, McLeod M, Li Y, Li CX, Feng A, Garabedian MJ, Wang Z, Roeder RG, Lee P. Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5236-41. Epub 2008 Mar 20. Cited in Pubmed; PMID 18356297.

Nonaka D, Laser J, Tucker R, Melamed J. Immunohistochemical evaluation of necrotic malignant melanomas. Am J Clin Pathol. 2007;127:787-91. Cited in Pubmed; PMID 17439838.

Kong X, Zhao Y, Ksionsk M, Zhou M, Walden P, Bosland M, Pei Z, Lee P, Melamed J. Radiographic determination of tissue thickness in paraffin blocks: Application to the construction of tissue microarrays. Applied Immunohistochemistry & Molecular Morphology. 2007;15(1):108-12. Cited in Pubmed; PMID 17536317.

Kajdacsy-Balla A, Geynisman JM, Macias V, Setty S, Nanaji NM, Berman JJ, Dobbin K, Melamed J, Kong X, Bosland M, Orenstein J, Bayerl J, Becich MJ, Dhir R, Datta MW. Practical aspects of planning, building, and interpreting tissue microarrays: The Cooperative Prostate Cancer Tissue Resource experience. J Mol Histol. 2007;38:113-21. Cited in Pubmed; PMID 17318343.

Liang JJ, Wang Z, Chiriboga L, Greco MA, Shapiro E, Huang H, Yang XJ, Huang J, Peng Y, Melamed J, Garabedian MJ, Lee P. The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. J Urol. 2007;177(5):1918-22. Cited in Pubmed; PMID 17437848.

Liu Q, Bannan M, Melamed J, Witkin GB, Nonaka D. Two cases of hepatoid adenocarcinoma of the intestine in association with inflammatory bowel disease. Histopathology. 2007;51(1):123-5. Cited in Pubmed; PMID 17532770.

Guo Z, Dai B, Jiang T, Xu K, Xie Y, Kim O, Nesheiwat I, Kong X, Melamed J, Handratta VD, Njar VC, Brodie AM, Yu LR, Veenstra TD, Chen H, Qiu Y. Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell. 2006;10:309-19. Cited in Pubmed; PMID 17045208.

Dai B, Kim O, Xie Y, Guo Z, Xu K, Wang B, Kong X, Melamed J, Chen H, Bieberich CJ, Borowsky AD, Kung HJ, Wei G, Ostrowski MC, Brodie A, Qiu Y. Tyrosine Kinase Etk/BMX Is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse. Cancer Res. 2006;66:8058-64. Cited in Pubmed; PMID 16912182.

Gao S, Wang H, Lee P, Melamed J, Li CX, Zhang F, Wu H, Zhou L, Wang Z. Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J Mol Endocrinol. 2006;36(3):463-83. Cited in Pubmed; PMID 16720717.

Wei JJ, Chiriboga L, Arslan AA, Melamed J, Yee H, Mittal K. Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata. Human Reproduction. 2006 Jan;21(1):57-67. Cited in Pubmed; PMID 16172143.

Chiriboga L, Zhao Y, Wei J, Melamed J. Repair of fractured, or thin tissue microarray paraffin blocks. Journal of Surgical Oncology. 2006;93(4):245-8.

Patel AA, Gilbertson JR, Parwani AV, Dhir R, Datta MW, Gupta R, Berman JJ, Melamed J, Kajdacsy-Balla A, Orenstein J, Becich MJ. An informatics model for tissue banks - Lessons learned from the Cooperative Prostate Cancer Tissue Resource. BMC Cancer. 2006;6(1):120. Cited in Pubmed; PMID 16677389.

Tong GX, Melamed J, Mansukhani M, Memeo L, Hernandez O, Deng FM, Chiriboga L, Waisman J. PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol. 2006;19(3):356-63. Cited in Pubmed; PMID 16400326.

Taneja SS, Ha S, Swenson NK, Huang HY, Lee P, Melamed J, Shapiro E, Garabedian MJ, Logan SK. Cell-specific regulation of androgen receptor phosphorylation in vivo. J Biol Chem. 2005 Dec 9;280(49):40916-24. Cited in Pubmed; PMID 16210317.

Patel AA, Kajdacsy-Balla A, Berman JJ, Bosland M, Datta MW, Dhir R, Gilbertson J, Melamed J, Orenstein J, Tai KF, Becich MJ. The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience. BMC Cancer. 2005 Aug 21;5(1):108. Cited in Pubmed; PMID 16111498.

Organizational Associations

International Academy of Pathology; International Society of Urology Pathology; New York Pathology Society

Selected Awards

Named one of New York magazine's Best Doctors.

Hospital Affiliations

Tisch Hospital