Research and Clinical Interests
My clinical interests are in applying new technology in the clinical laboratories. This is of particular importance in the clinical microbiology lab where culturing microorganisms may require days to weeks. Newer molecular techniques allow for more rapid diagnosis and identification of drug resistance. Application of existing technologies, such as GC-MS to microbiologic specimens is leading to rapid identification with just a small amount of clinical material.
McVoy LA, Kew RR. Actin as a Cell Surface Receptor for the Vitamin D Binding Protein on Leukocytes. (Manuscript in Progress). Forthcoming.
Lytkin NI, McVoy L, Weitkamp JH, Aliferis CF, Statnikov A. Expanding the understanding of biases in development of clinical-grade molecular signatures: a case study in acute respiratory viral infections. PLoS One. 2011;6(6):e20662. Epub 2011 Jun 1. Cited in Pubmed; PMID 21673802. doi: 10.1371/journal.pone.0020662. PMCID: PMC3105991.
Statnikov A, Lytkin NI, McVoy L, Weitkamp JH, Aliferis CF. Using gene expression profiles from peripheral blood to identify asymptomatic responses to acute respiratory viral infections. BMC Res Notes. 2010 Oct 20;3:264. Cited in Pubmed; PMID 20961438. doi: 10.1186/1756-0500-3-264. PMCID: PMC2975649.
Statnikov A, McVoy L, Lytkin N, Aliferis CF. Improving development of the molecular signature for diagnosis of acute respiratory viral infections. Cell Host Microbe. 2010 Feb 18;18;7(2):100-1; author reply 102. Cited in Pubmed; PMID 20159615. doi: 10.1016/j.chom.2010.01.003. PMCID: PMC2824607.
McVoy LA, Jacobson J. Mixed field detection in solid phase testing. American Association of Blood Banks Annual Meeting. 2009;
McVoy LA, Hanna B. Six-year retrospective of mycobacterial testing of CSF at Bellevue Hospital. Interscience Conference on Antimicrobial Agents and Chemotherapy. 2009;
DiMartino SJ, Trujillo G, McVoy LA, Zhang J, Kew RR. Upregulation of vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules. Mol Immunol. 2007 Mar;44(9):2370-7. Epub 2006 Nov 20. Cited in Pubmed; PMID 17113648. doi: 10.1016/j.molimm.2006.10.011. PMCID: PMC1819475.
McVoy LA, Kew RR. CD44 and annexin A2 mediate the C5a chemotactic cofactor function of the vitamin D binding protein. J Immunol. 2005 Oct 1;175(7):4754-60. Cited in Pubmed; PMID 16177123.
McVoy LA, Kew RR. Identification of vitamin D protein binding ligands on the surface of U937 cells and neutrophils. 18th Annual MD/PhD Conference. 2003;
McVoy LA, Kew RR. Identification of leukocyte cell surface ligands for the vitamin D binding protein. 36th Annual Meeting of the Society for Leukocyte Biology. 2003;
Melchor JP, McVoy L, Van Nostrand WE. Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein. J Neurochem. 2000 May;74(5):2209-12. Cited in Pubmed; PMID 10800967. doi: 10.1046/j.1471-4159.2000.0742209.x.
College of American Pathologists; American Society for Clinical Pathology; American Association for Clinical Chemistry; American Society for Microbiology