David E. Levy, Ph.D.
Dr. Louis A. Schneider Professor of Molecular Pathology and Vice Chair for Science and Professor of Microbiology
Director, Pathobiology Graduate Training Program
Graduate Advisor, Molecular Oncology and Immunology Graduate Training Program
Experimental Pathology, Immunology, Molecular Oncology, Pathobiology / Signal transduction, gene expression, innate immunity, growth control
David.Levy@nyumc.org, (212) 263 8192
Fax: (509) 757 3029
550 First Avenue, MSB 548, New York, NY 10016
Research and Clinical Interests
Intracellular signal transduction pathways regulating gene expression impact diverse cell functions such as normal cell growth, differentiation, and immune responses to pathogens. Disruptions of these pathways occur in many diseases, from impaired immunity to cancer. We are particularly interested in signaling utilizing JAK-STAT pathways and study their molecular mechanisms using biochemical, cell biological, genetic, and genomic approaches in vitro and in genetically modified mice.
Selected Publications
Satterly N, Tsai PL, can Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BM. Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proc. Natl. Acad. Sci U S A. 2007;14:1853–8. Cited in Pubmed; PMID 17267598.
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs Th17 cell differentiation by promoting the sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8:967–74. Epub 2007 Jun 20. Cited in Pubmed; PMID 17581537.
Wang Y, Levy DE. C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation. Curr. Bio. 2006;16:89–94. Cited in Pubmed; PMID 16401427.
Chou WC, Levy DE, Lee CK. STAT3 positively regulates an early step in B-cell development. Blood. 2006;108:3005–11. Cited in Pubmed; PMID 16825489.
Faria AMC, Levay A, Wang Y, Kamphorst AO, Rosa MLP, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BMA. The Nucleoporin Nup96 is Required for Proper Expression of Interferon-Regulated Proteins and Functions. Immunity. 2006;24:295–304. Cited in Pubmed; PMID 16546098.
Schlessinger K, Levy DE. Malignant transformation but not normal cell growth depend on STAT3. Cancer Res. 2005;65:5828–34. Cited in Pubmed; PMID 15994959.
Caillaud A, Hovanessian AG, Levy DE, Marié IJ. Regulatory Serine Residues Mediate Phosphorylation-dependent and Phosphorylation-independent Activation of Interferon Regulatory Factor 7. J. Biol. Chem. 2005;280:17671–77. Cited in Pubmed; PMID 15743772.
Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, Karras J, Levy DE, Inghirami G. Stat3 is required for ALK-mediated lymphomagenesis and provides a viable therapeutic target. Nature Med. 2005;11:623–9. Cited in Pubmed; PMID 15895073.
Prakash A, Smith E, Lee CK, Levy DE. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J. Biol. Chem. 2005;280:18651–7. Cited in Pubmed; PMID 15767254.
Gimeno R, Lee CK, Schindler C, Levy DE. Stat1 and Stat2 but not Stat3 Arbitrate Contradictory Growth Signals Elicited by alpha/beta Interferon in T Lymphocytes. Mol. Cell. Biol. 2005;25:5456–65. Cited in Pubmed; PMID 15964802.
Chang HM, Paulson M, Holko M, Rice CM, Williams BRG, Marié IJ, Levy DE. Induction of Interferon-Stimulated Gene Expression and Antiviral Responses Require Protein Deacetylase Activity. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9578–83. Cited in Pubmed; PMID 15210966.
Lee CK, Raz R, Gimeno R, Wistinghausen B, Takeshita K, DePinho R, Levy DE. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 2002 Jul;17(1):63–72. Cited in Pubmed; PMID 12150892.
Paulson M, Press C, Smith E, Tanese N, Levy DE. IFN Stimulated Transcription Through a TBP-Free Acetyltransferase Complex Escapes Viral Shutoff. Nat Cell Biol. 2002 Feb;4(2):140–7. Cited in Pubmed; PMID 11802163.
Marié I, Smith E, Prakash A, Levy DE. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and bipartite transactivation domain. Mol Cell Biol. 2000 Dec;20(23):8803–14. Cited in Pubmed; PMID 11073981.
Lee CK, Gimeno R, Levy DE. Differential regulation of constitutive MHC class I expression in T and B lymphocytes. J Exp Med. 1999 Nov 15;190(10):1451–64. Cited in Pubmed; PMID 10562320.
Selected Books
Sehgal PB, Levy DE, Hirano T, editors. Signal Transducers and Activators of Transcription (STATs). Activation and Biology. Dordrecht: Kluwer Academic Publishers; 2003.
Organizational Associations
International Society for Interferon and Cytokine Research, American Society for Microbiology, American Society for Biochemistry and Molecular Biology
Selected Awards
Dr. Louis A. Schneider Chair in Molecular Pathology
Milstein Award of the ISICR
Hirschl Trust Career Scientist
Whitehead Presidential Fellow, NYU
Pew Scholar in the Biomedical Sciences
Investigator, Cancer Research Institute
Junior Faculty Research Award from the American Cancer Society
Kaplan Scholar, Rita & Stanley H. Kaplan Cancer Center of NYU
