Research and Clinical Interests

Intracellular signal transduction pathways regulating gene expression impact diverse cell functions such as normal cell growth, differentiation, and immune responses to pathogens. Disruptions of these pathways occur in many diseases, from impaired immunity to cancer. We are particularly interested in signaling utilizing JAK-STAT pathways and study their molecular mechanisms using biochemical, cell biological, genetic, and genomic approaches in vitro and in genetically modified mice.

Selected Publications

Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 2010 Sep 9;467(7312):214–7. doi: 10.1038/nature09337. PMCID: PMC3051279.

Gough DJ,* Corlett A,* Schlessinger K, Wegrezyn J, Larner AC, Levy DE. Mitochondrial Stat3 Supports Ras-Dependent Oncogenic Transformation. Science. 2009 Jun 26;324(5935):1713-16. Epub 2009 Jun 26. doi: 10.1126/science.1171721.

Satterly N, Tsai PL, can Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BM. Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proc Natl Acad Sci U S A. 2007;14:1853–8. Cited in Pubmed; PMID 17267598. doi: 10.1073/pnas.0610977104. PMCID: PMC1794296.

Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs Th17 cell differentiation by promoting the sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8:967–74. Epub 2007 Jun 20. Cited in Pubmed; PMID 17581537. doi: 10.1038/ni1488.

Wang Y, Levy DE. C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation. Curr. Bio. 2006;16:89–94. Cited in Pubmed; PMID 16401427. doi: 10.1016/j.cub.2005.11.061.

Chou WC, Levy DE, Lee CK. STAT3 positively regulates an early step in B-cell development. Blood. 2006;108:3005–11. Cited in Pubmed; PMID 16825489.

Faria AMC, Levay A, Wang Y, Kamphorst AO, Rosa MLP, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BMA. The Nucleoporin Nup96 is Required for Proper Expression of Interferon-Regulated Proteins and Functions. Immunity. 2006;24:295–304. Cited in Pubmed; PMID 16546098.

Schlessinger K, Levy DE. Malignant transformation but not normal cell growth depend on STAT3. Cancer Res. 2005;65:5828–34. Cited in Pubmed; PMID 15994959.

Prakash A, Smith E, Lee CK, Levy DE. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J. Biol. Chem. 2005;280:18651–7. Cited in Pubmed; PMID 15767254.

Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, Karras J, Levy DE, Inghirami G. Stat3 is required for ALK-mediated lymphomagenesis and provides a viable therapeutic target. Nature Med. 2005;11:623–9. Cited in Pubmed; PMID 15895073.

Gimeno R, Lee CK, Schindler C, Levy DE. Stat1 and Stat2 but not Stat3 Arbitrate Contradictory Growth Signals Elicited by alpha/beta Interferon in T Lymphocytes. Mol. Cell. Biol. 2005;25:5456–65. Cited in Pubmed; PMID 15964802.

Caillaud A, Hovanessian AG, Levy DE, Marié IJ. Regulatory Serine Residues Mediate Phosphorylation-dependent and Phosphorylation-independent Activation of Interferon Regulatory Factor 7. J. Biol. Chem. 2005;280:17671–77. Cited in Pubmed; PMID 15743772.

Chang HM, Paulson M, Holko M, Rice CM, Williams BRG, Marié IJ, Levy DE. Induction of Interferon-Stimulated Gene Expression and Antiviral Responses Require Protein Deacetylase Activity. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9578–83. Cited in Pubmed; PMID 15210966.

Lee CK, Raz R, Gimeno R, Wistinghausen B, Takeshita K, DePinho R, Levy DE. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 2002 Jul;17(1):63–72. Cited in Pubmed; PMID 12150892.

Paulson M, Press C, Smith E, Tanese N, Levy DE. IFN Stimulated Transcription Through a TBP-Free Acetyltransferase Complex Escapes Viral Shutoff. Nat Cell Biol. 2002 Feb;4(2):140–7. Cited in Pubmed; PMID 11802163.

Selected Books

Sehgal PB, Levy DE, Hirano T, editors. Signal Transducers and Activators of Transcription (STATs). Activation and Biology. Dordrecht: Kluwer Academic Publishers; 2003.

Organizational Associations

International Society for Interferon and Cytokine Research, American Society for Microbiology, American Society for Biochemistry and Molecular Biology

Selected Awards

Dr. Louis A. Schneider Chair in Molecular Pathology
Milstein Award of the ISICR
Hirschl Trust Career Scientist
Whitehead Presidential Fellow, NYU
Pew Scholar in the Biomedical Sciences
Investigator, Cancer Research Institute
Junior Faculty Research Award from the American Cancer Society
Kaplan Scholar, Rita & Stanley H. Kaplan Cancer Center of NYU
2010 Elected Fellow of the American Association for the Advancement of Science (AAAS)

Additional Information

Levy Lab Research Profile