Peng Lee, M.D., Ph.D.
Associate Professor of Pathology and Urology
Director, Molecular Genetic Pathology, New York Harbor Healthcare System
Co-director, Genetic Program, Center of Excellence on Urologic Disease
Molecular Oncology, Molecular Pathology, Urologic Pathology / Oncologic, GU & Molecular Pathology; Androgen receptor function, cofactors and target genes in prostate and breast cancer
Peng.Lee@nyumc.org, (212) 951 3418
Fax: (212) 951 6341
423 East 23rd Street, VET 6140N, New York, NY 10010
Research and Clinical Interests
The long-term goal of the laboratory is to elucidate the mechanism and function of the androgen receptor (AR), its cofactors and target genes in endocrine malignancies including breast and prostate cancer and to apply these findings to clinically relevant issues: identifying prognostic and predictive biomarkers and discovering novel therapeutic strategies for cancer.
Selected Publications
Li Y, Wang L, Zhang M, Melamed J, Liu X, Reiter R, Wei J, Peng Y, Zou X, Pellicer A, Garabedian MJ, Ferrari A, Lee P. LEF1 in Androgen-Independent Prostate Cancer: Regulation of Androgen Receptor Expression, Prostate Cancer Growth, and Invasion. Cancer Res. 2009 Apr 15;Epub 2009 Apr 7. Cited in Pubmed; PMID 19351848. doi: 10.1158/0008-5472.CAN-08-3380.
Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez-Diaz S, Zakrzewski J, Blochin E, Rose A, Bogunovic D, Polsky D, Wei J, Lee P, Belitskaya-Levy I, Bhardwaj N, Osman I, Hernando H. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1814–9. Epub 2009 Feb 2. Cited in Pubmed; PMID 19188590. doi: 10.1073/pnas.0808263106. PMCID: PMC2634798.
Cai CQ, Peng Y, Buckley MT, Wei J, Chen F, Liebes L, Gerald WL, Pincus MR, Osman I, Lee P. Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations. Oncogene. 2008 May 15;27(22):3201-10. Epub 2008 Jan 14. Cited in Pubmed; PMID 18193092.
Peng Y, Chen F, Melamed J, Chiriboga L, Wei J, Kong X, McLeod M, Li Y, Li CX, Feng A, Garabedian MJ, Wang Z, Roeder RG, Lee P. Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5236-41. Epub 2008 Mar 20. Cited in Pubmed; PMID 18356297.
Dash A, Lee P, Zhou Q, Jean-Gilles J, Taneja S, Satagopan J, Reuter V, Gerald W, Eastham J, Osman I. Impact of Socioeconomic Factors on Prostate Cancer Outcomes in Black Patients Treated with Surgery. Urology. 2008 Feb 21;Epub 2008 Feb 21. Cited in Pubmed; PMID 18295314.
Li Y, Li CX, Ye H, Chen F, Melamed J, Yi P, Liu J, Wang Z, Tsou HC, Wei J, Walden P, Garabedian MJ, Lee P. Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion. J Cell Mol Med. 2008 Feb 8;Epub 2008 Feb 8. Cited in Pubmed; PMID 18266956.
Peng Y, Li CX, Chen F, Wang Z, Ligr M, Melamed J, Wei J, Gerald W, Pagano M, Garabedian MJ, Lee P. Stimulation of prostate growth and invasion by androgen receptor cofactor ARA70β. American Journal of Pathology. 2008 Jan;172(1):225-35. Epub 2007 Dec 21. Cited in Pubmed; PMID 18156210.
Cai GP, Huang HY, Shapiro E, Zhou H, Yeh S, Melamed J, Greco MA and Lee P. Expression of androgen receptor-associated protein 55 (ARA55) in the developing human fetal prostate. Journal of Urology. 2005;173:2190-3.
Taneja SS, Ha S, Swenson NK, Huang HY, Lee P, Melamed J, Shapiro E, Garabedian MJ, Logan SK. Cell specific regulation of androgen receptor phosphorylation in vivo. Journal of Biological Chemistry. 2005;280:40916.
Gao S, Lee P, Wang H, Gerald W, Adler M, Zhang LY, Wang YF, and Wang ZX. The androgen receptor directly targets the c-FLIP gene to promote the androgen-independent growth of prostate cancer cells. Molecular Endocrinology. 2005;19(7):1792-802.
Schuch B, Mikhail M, Satagopan J, Lee P, Yee H, Chang C, Cordon-Cardo C, Taneja S, Osman I. Racial Disparity of Epidermal Growth Factor Receptor Expression in Prostate Cancer. J. Clinic Oncology. 2004;22(23):4673-7.
Hosohata K*, Li P*, Hosohata Y, Qin J, Roeder RG, Wang Z. Purification and Identification of a Novel Complex which is involved in Androgen Receptor-Dependent Transcription. Molecular and Cellular Biology. 2003;23(19):7019–29.
Li P, Yu X, Ge K, Melamed J, Roeder R, Wang ZX. Heterogeneous expression and function of androgen receptor cofactors in primary prostate cancer. American Journal of Pathology. 2002;161(4):1467-74.
Yu X, Li P, Roeder R, Wang ZX. Inhibition of androgen receptor-mediated transcription by the amino-terminal enhancer of split. Molecular and Cellular Biology. 2001;21(14):4614-25.
Li P, McLeod M. Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase. Cell. 1996;87:869–80.
Selected Books and Reviews
Lee P, Pincus MR, McPherson MA. Diagnosis and management of cancer using serologic tumor markers. In: McPherson and Pincus MR,, editors. Henry’s Clinical Diagnosis and Management by Laboratory Methods. 21st. Philadelphia: Saunders Elsevier; 2007. pp. 1353–66.
Cheng J, Bawa T, Lee P, Gong L, Yeh ETH. Role of De-Sumoylation in the Development of Prostate Cancer. Neoplasia. 2006;8(8):667–78.
Lee P, Wang ZX. Role of androgen receptor cofactors in human prostate cancer. In: Hayat MA, editor. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas. Vol. 2. Amsterdam: Elsevier Academic Press; 2004. pp. 409-22.
Hospital Affiliations
VA Hospital
