People

Selected Publications

Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature. 2011 Apr 28;472(7344):472(7344). Cited in Pubmed; PMID 21441909. doi: 10.1038/nature09978.

Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML. Protein Kinase C-theta Mediates Negative Feedback on Regulatory T Cell Function. Science. 2010 Apr 16;328(5976):372-6. Cited in Pubmed; PMID 20339032. doi: 10.1126/science.1186068. PMCID: PMC2905626.

Leung MW, Shen S, Lafaille JJ. TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J Exp Med. 2009 Sep 28;206(10):2121-30. Cited in Pubmed; PMID 19737865. doi: 10.1084/jem.20091033. PMCID: PMC2757883.

Curotto de Lafaille MA, Lafaille JJ. Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor? Immunity. 2009;5:626-35. Cited in Pubmed; PMID 19464985. doi: doi:10.1016/j.immuni.2009.05.002.

Curotto de Lafaille MA, Kutchukhidze N, Shen S, Ding Y, Yee H, and Lafaille JJ. Adaptive Foxp3+ Regulatory T cell-dependent and -independent control of allergic inflammation. Immunity. 2008 Jul 18;29:114-26. Cited in Pubmed; PMID 18617425. doi: 10.1016/j.immuni.2008.05.010.

Ding Y, Shen S, Lino AC, Curotto de Lafaille MA, Lafaille JJ. Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nat Med. 2008 Feb;14(2):162-9. Cited in Pubmed; PMID 18246080. doi: 10.1038/nm1707.

Maraver A, Tadokoro CE, Badura ML, Shen J, Serrano M, Lafaille JJ. Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood. 2007 Nov 1;110:3218-25. Cited in Pubmed; PMID 17626841.

Erazo A, Kutchukhidze N, Leung M, Christ AP, Urban JF Jr, Curotto de Lafaille MA, Lafaille JJ. Unique maturation program of the IgE response in vivo. Immunity. 2007 Feb;26(2):191-203. Cited in Pubmed; PMID 17292640.

Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33. Cited in Pubmed; PMID 16990136.

Marcondes MC, Furtado GC, Wensky A, Curotto de Lafaille MA, Fox HS, Lafaille JJ. Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis. Am J Pathol. 2005 Jun;166(6):1749–60. Cited in Pubmed; PMID 15920160.

Yan SS; Wu ZY; Zhang HP; Furtado G; Chen X; Yan SF; Schmidt AM; Brown C; Stern A; Lafaille J; Chess L; Stern DM; Jiang H. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med. 2003;9:287-93. Cited in Pubmed; PMID 12598893.

Selected Books and Reviews

Bilate AB, Lafaille JJ. It takes two to tango. Immunity. 2011 Jul 22;35(1):6-8. Cited in Pubmed; PMID 21777793. doi: 10.1016/j.immuni.2011.07.003.

Curotto de Lafaille MA, Lafaille JJ. The biology of IgE: The generation of High Affinity IgE Antibodies (Chapter 3). In: Penichet ML, Jensen-Jarolim E, editors. Cancer and IgE: Introducing the Concept of AllergoOncology. Springer: 2010. pp. 37-46.