Research and Clinical Interests

I am taking advantage of conditional gene targeting to examine two distinct riddles. My first goal is to understand the role of RNAi in B cell development and function—in particular the role of short non-coding RNAs in epigenetic control of Ig loci. The second goal is to investigate the link between chronic inflammation, autoimmunity and cancer with specific focus on Th17 driven inflammation and T cell lymphomagenesis.

Selected Publications

Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Müller M. Hyperactivation of NFAT1 in T cells attenuates development of murine autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15169-74. Epub 2010 Aug 9. Cited in Pubmed; PMID 20696888. doi: 10.1073/pnas.1009193107. PMCID: PMC2930568.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT. Enhanced Stat3-activation in POMC-neurons provokes negative feedback inhibition of leptin- and insulin-signaling in obesity. J Neurosci. 2009 Sep 16;29(37):11582-93. Cited in Pubmed; PMID 19759305. doi: 10.1523/JNEUROSCI.5712-08.2009.

Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2009 Jun 5;324(5932):1334-8. Cited in Pubmed; PMID 19498172. doi: 10.1126/science.1172638. PMCID: PMC2803727.

Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, Jensen K, Cobb BS, Merkenschlager M, Rajewsky N, Rajewsky K. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74. Cited in Pubmed; PMID 18329371. doi: 10.1016/j.cell.2008.02.020.

Mesaros A*, Koralov SB*, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC. Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab. 2008 Mar;7(3):236-48. Cited in Pubmed; PMID 18316029. doi: 10.1016/j.cmet.2008.01.007.

Edry E, Koralov SB, Rajewsky K, Melamed D. Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement. J Immunol. 2007 Nov 15;179(10):6555-60. Cited in Pubmed; PMID 17982044.

Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K. Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity. 2006 Jul;25(1):43-53. Cited in Pubmed; PMID 16860756. doi: 10.1016/j.immuni.2006.04.016.

Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401. Epub 2006 May 1. Cited in Pubmed; PMID 16651521. doi: 10.1073/pnas.0602353103. PMCID: PMC1464351.

Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K. Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med. 2005 Feb 7;201(3):341-8. Cited in Pubmed; PMID 15699070. doi: 10.1084/jem.20041577. PMCID: PMC1237122.

Chen Z, Koralov SB, Kelsoe G. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med. 2000 Nov 6;192(9):1339-52. Cited in Pubmed; PMID 11067882. PMCID: PMC2193358.

Chen Z, Koralov SB, Gendelman M, Carroll MC, Kelsoe G. Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. J Immunol. 2000 May 1;164(9):4522-32. Cited in Pubmed; PMID 10779753.

Selected Books and Reviews

Sundrud M, Koralov SB. Chapter: Negative regulation of Th17 differentiation. In: Quesniaux V, Ryffel B, Padova F, editors. TH17 Cells in Health and Disease. New York: Springer (in Press); 2010.

Chen Z, Koralov SB, Kelsoe G. Regulation of humoral immune responses by CD21/CD35. Immunol Rev. 2000 Aug;176:194-204. Cited in Pubmed; PMID 11043778. doi: 10.1034/j.1600-065X.2000.00603.x.

Selected Awards

2011-2012 New York University Whitehead Fellowship for Junior Faculty in Biomedical and Biological Sciences