Research and Clinical Interests

Improper control of cell proliferation leads to developmental defects and disease, yet how proliferation is controlled within the whole-organism context is poorly understood. My research focuses on the control of cell proliferation using the C. elegans germ line as a model system. C. elegans offers a simple accessible anatomy and powerful molecular-genetic tools to study highly conserved aspects of proliferation control and related processes such as niche-stem cell interactions.

Selected Publications

McGovern M, Voutev R, Maciejowski J, Corsi AK, Hubbard EJ. A "latent niche" mechanism for tumor initiation. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11617-22. Epub 2009 Jun 29. Cited in Pubmed; PMID 19564624. doi: 10.1073/pnas.0903768106. PMCID: PMC2710656.

Voutev R, Hubbard EJ. A "FLP-out" system for controlled gene expression in Caenorhabditis elegans. Genetics. 2008 Sep;180(1):103-19. Epub 2008 Aug 24. Cited in Pubmed; PMID 18723890. doi: 10.1534/genetics.108.090274. PMCID: PMC2535667.

Kam N, Kugler H, Marelly R, Appleby L, Fisher J, Pnueli A, Harel D, Stern MJ, Hubbard EJ. A scenario-based approach to modeling development: A prototype model of C. elegans vulval fate specification. Dev Biol. 2008 Jul 31;Epub 2008 Jul 31. Cited in Pubmed; PMID 18706404. doi: doi:10.1016/j.ydbio.2008.07.030.

Voutev R, Killian DJ, Ahn JH, Hubbard EJ. Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Dev Biol. 2006 Oct 1;298(1):45-58. Epub 2006 Jun 8. Cited in Pubmed; PMID 16876152.

Maciejowski J, Ugel N, Mishra B, Isopi M, Hubbard EJ. Quantitative analysis of germline mitosis in adult C. elegans. Dev Biol. 2006 Apr 1;292(1):142-51. Cited in Pubmed; PMID 15733661.

Maciejowski J, Ahn JH, Cipriani PG, Killian DJ, Chaudhary AL, Lee JI, Voutev R, Johnsen RC, Baillie DL, Gunsalus KC, Fitch DH, Hubbard EJ. Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics. 2005 Apr;169(4):1997-2011. Epub 2005 Jan 31. Cited in Pubmed; PMID 15687263.

Killian DJ, Hubbard EJ. Caenorhabditis elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ line. Dev Biol. 2005 Mar 15;279(2):322-35. Cited in Pubmed; PMID 15733661.

Fisher J, Piterman N, Hubbard EJ, Stern MJ, Harel D. Computational insights into Caenorhabditis elegans vulval development. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1951-6. Epub 2005 Jan 31. Cited in Pubmed; PMID 15684055.

Hansen D, Hubbard EJ, Schedl T. Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline. Dev Biol. 2004 Apr 15;268(2):342-57. Cited in Pubmed; PMID 15063172.

Killian DJ, Hubbard EJ. C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line. Development. 2004 Mar;131(6):1267-78. Epub 2004 Feb 18. Cited in Pubmed; PMID 14973273.

Pepper AS, Lo TW, Killian DJ, Hall DH, Hubbard EJ. The establishment of Caenorhabditis elegans germline pattern is controlled by overlapping proximal and distal somatic gonad signals. Dev Biol. 2003 Jul 15;259(2):336-50. Cited in Pubmed; PMID 12871705.

Pepper AS, Killian DJ, Hubbard EJ. Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition. Genetics. 2003 Jan;163(1):115-32. Cited in Pubmed; PMID 12586701.

Wu G, Hubbard EJ, Kitajewski JK, Greenwald I. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15787-91. Cited in Pubmed; PMID 9861048.

Hubbard EJ, Wu G, Kitajewski J, Greenwald I. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 1997 Dec 1;11(23):3182-93. Cited in Pubmed; PMID 9389650.

Hubbard EJ, Dong Q, Greenwald I. Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans. Science. 1996 Jul 5;273(5271):112-5. Cited in Pubmed; PMID 8658178.

Selected Books and Reviews

Korta DZ, Hubbard EJA. Soma-germline interactions that influence germline proliferation in Caenorhabditis elegans (review). Dev Dyn. 2010 Mar;Epub 2010 Mar 11. Cited in Pubmed; PMID 20225254. doi: 10.1002/dvdy.22268.

Hubbard EJA. Model organisms as powerful tools for biomedical research. In: Creager ANH, Lunbeck E, Wise MN, editors. Science without Laws: Model Systems, Cases and Exemplary Narratives. Durham, NC: Duke University Press; 2007.

Hubbard EJ. Caenorhabditis elegans germ line: A model for stem cell biology [review]. Dev Dyn. 2007 Dec;236(12):3343-57. Cited in Pubmed; PMID 17948315. doi: 10.1002/dvdy.21335.

Hubbard EJA, Greenstein D. Introduction to the germ line (September 1, 2005). In: The C. elegans Research Community. WormBook. 2005.

Kam N, Harel D, Kugler H, Marelly R, Pnueli A, Hubbard EJA, Stern MJ. Formal Modeling of C. elegans Development: A Scenario Based Approach. In: Ciobanu G, editor. Modeling in Molecular Biology, Natural Computing Series. Berlin: Springer; 2004.

Hubbard EJ, Pera RA. A germ-cell odyssey: fate, survival, migration, stem cells and differentiation. Meeting on germ cells [review]. EMBO Rep. 2003 Apr;4:352-7. Epub 2003 Mar 21. Cited in Pubmed; PMID 12671678.

Mishra B, Daruwala R, Zhou Y, Ugel N, Policriti A, Antoniotti M, Paxia S, Rejali M, Rudra A, Cherepinsky V, Silver N, Casey W, Piazza C, Simeoni M, Barbano P, Spivak M, Feng JW, Gill O, Venkatesh M, Cheng F, Sun B, Ioniata I, Anantharaman TS, Hubbard EJA, Pnueli A, Harel D, Chandru V, Hariharan R, Wigler M, Park F, Lin SC, Lazebnik Y, Winkler F, Cantor C, Carbone A, Gromov M. A Sense of Life: Computational & Experimental Investigations with Models of Biochemical & Evolutionary Processes. OMICS - A Journal of Integrative Biology (Special Issue on BioCOMP, Ed.: S. Kumar). 2003;7(3):253-68.

Hubbard EJ, Greenstein D. The Caenorhabditis elegans gonad: a test tube for cell and developmental biology [review]. Dev Dyn. 2000 May;218(1):2-22. Cited in Pubmed; PMID 10822256.

Organizational Associations

Genetics Society of America; Society for Developmental Biology

Selected Awards

Golden Dozen Award, College of Arts and Sciences, New York University
Samuel W. Rover and Lewis Rover Award in Genetics and Development, Columbia University (departmental thesis award)
Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship
NCI Predoctoral Training Grant in Cancer Biology

Additional Information

Hubbard Lab