People

Research and Clinical Interests

My laboratory has been investigating the role of HIV envelope gp120 and antibodies directed to this antigen in immunopathogenesis of HIV. We are also exploring different approaches to dampen the pathogenic effects of HIV gp120 while enhancing the immunogenicity of this important antigenic target. Recently, we are analyzing HIV gp120-mediated synapse and signaling in order to identify new targets for anti-HIV interventions.

Selected Publications

Agarwal A, Hioe CE, Swetnam J, Zolla-Pazner S, Cardozo T. Quantitative assessment of masking of neutralization epitopes in HIV-1. Vaccine. 2011 Jan 7;Cited in Pubmed; PMID 21216319. doi: 10.1016/j.vaccine.2010.12.052. PMCID: PMC3135678 [Available on 2012/7/7].

Hioe CE, Wrin T, Seaman MS, Yu X, Wood B, Self S, Williams C, Gorny MK, Zolla-Pazner S. Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes. PLoS One. 2010 Apr 21;5(4):e10254. Cited in Pubmed; PMID 20421997. doi: 10.1371/journal.pone.0010254. PMCID: PMC2858080.

Vasiliver-Shamis G, Tuen M, Wu TW, Starr T, Cameron TO, Thomson R, Kaur G, Liu J, Visciano ML, Li H, Kumar R, Ansari R, Han DP, Cho MW, Dustin ML, Hioe CE. Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells. J Virol. 2008 Oct;82(19):9445-57. Cited in Pubmed; PMID 18632854. doi: 10.1128/JVI.00835-08. PMCID: PMC2546991.

Visciano ML, Tuen M, Chen PD, Hioe CE. Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response. Infect Agent Cancer. 2008 Jul 18;3:11. Cited in Pubmed; PMID 18638381.

Li H, Chien PC Jr, Tuen M, Visciano ML, Cohen S, Blais S, Xu CF, Zhang HT, Hioe CE. Identification of an N-linked glycosylation site in the C4 region of HIV-1 envelope gp120 that is critical for recognition of neighboring CD4 T cell epitopes. J Immunol. 2008 Mar 15;80(6):4011-21. Cited in Pubmed; PMID 18322210.

Visciano ML, Tuen M, Gorny M, Hioe CE. In vivo alteration of humoral responses to HIV envelope glycoprotein gp120 by antibodies to the CD4-binding site of gp120. Virology. 2008 Mar 15;372(2):409-20. Cited in Pubmed; PMID 18054978. doi: 10.1016/j.virol.2007.10.044 . PMCID: PMC2288784.

Kaur G, Tuen M, Virland D, Cohen S, Mehra NK, Munz C, Abdelwahab S, Garzino-Demo A, Hioe CE. Antigen stimulation induces HIV envelope gp120-specific CD4(+) T cells to secrete CCR5 ligands and suppress HIV infection. Virology. 2007 Dec 5;369(1):214-225. Cited in Pubmed; PMID 17765942.

Williams JG, Tomer KB, Hioe CE, Zolla-Pazner S, Norris PJ. The antigenic determinants on HIV p24 for CD4+ T cell inhibiting antibodies as determined by limited proteolysis, chemical modification, and mass spectrometry. J Am Soc Mass Spectrom. 2006 Nov;17(11):1560-9. Cited in Pubmed; PMID 16875837.

Tuen M, Visciano ML, Chien PC Jr, Cohen S, Chen PD, Robinson J, He Y, Pinter A, Gorny MK, Hioe CE. Characterization of antibodies that inhibit HIV gp120 antigen processing and presentation. Eur J Immunol. 2005 Sep;35(9):2541-51. Cited in Pubmed; PMID 16106369.

Chien PC Jr, Cohen S, Kleeberger C, Giorgi J, Phair J, Zolla-Pazner S, Hioe CE. High levels of antibodies to the CD4 binding domain of human immunodeficiency virus type 1 glycoprotein 120. J Infect Dis. 2004 Jul 15;186(2):205-13. Cited in Pubmed; PMID 12134256.

Chien PC Jr, Chen D, Chen PD, Tuen M, Cohen S, Migueles SA, Connors M, Rosenberg E, Malhotra U, Gonzalez C, Hioe CE. HIV-1-infected patients with envelope-specific lymphoproliferation or long-term nonprogression lack antibodies suppressing glycoprotein 120 antigen presentation. J Infect Dis. 2004 Mar 1;189(5):852-61. Cited in Pubmed; PMID 14976603.

Cohen S, Tuen M, Hioe CE. Propagation of CD4+ T cells specific for HIV type 1 envelope gp120 from chronically HIV type 1-infected subjects. AIDS Res Hum Retroviruses. 2003 Sep;19(9):793-806. Cited in Pubmed; PMID 14585210.

Hioe CE, Tuen M, Chien PC Jr, Jones G, Ratto-Kim S, Norris PJ, Moretto WJ, Nixon DF, Gorny MK, Zolla-Pazner S. Inhibition of human immunodeficiency virus type 1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120. J Virol. 2001 Nov;75(22):10950-7. Cited in Pubmed; PMID 11602735.

Hioe CE, Jones GJ, Rees AD, Ratto-Kim S, Birx D, Munz C, Gorny MK, Tuen M, Zolla-Pazner S. Anti-CD4-binding domain antibodies complexed with HIV type 1 glycoprotein 120 inhibit CD4+ T cell-proliferative. AIDS Res Hum Retroviruses. 2000 Jun 10;16(9):893-905. Cited in Pubmed; PMID 10875615.

Hioe CE, Hildreth JE, Zolla-Pazner S. Enhanced HIV type 1 neutralization by human anti-glycoprotein 120 monoclonal antibodies in the presence of monoclonal antibodies. AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):523-31. Cited in Pubmed; PMID 10221529.

Organizational Associations

Sigma Xi; American Association for Immunologists