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Research and Clinical Interests

Our lab is studying whether a developmental model of tumorigenesis can be applied to solid cancers, in particular to sarcomas and melanomas. We hypothesize that these tumors originate from stem cells or precursors retaining self-renewal capacity, whose neoplastic transformation involves a differentiation blockade. By determining the relationship between 'cell-of-origin' and 'cancer stem cells' we hope to improve our understanding of the mechanisms of sarcoma and melanoma initiation/progression. Read more about research in the Hernando Lab.

Selected Publications

Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez-Diaz S, Zakrzewski J, Blochin E, Rose A, Bogunovic D, Polsky D, Wei J, Lee P, Belitskaya-Levy I, Bhardwaj N, Osman I, Hernando H. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1814–9. Epub 2009 Feb 2. Cited in Pubmed; PMID 19188590. doi: 10.1073/pnas.0808263106. PMCID: PMC2634798.

Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008 Jun 13;133(6):1006-18. Cited in Pubmed; PMID 18555777. doi: 10.1016/j.cell.2008.03.038.

Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani A, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M. Control of chromosome stability by the βTRCP-REST-MAD2 axis. Nature. 2008 Mar 20;452:365-9. Cited in Pubmed; PMID 18354482.

Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell. 2007;11:1-15. Cited in Pubmed; PMID 17189715.

Feng Z, Hu W, Teresky AK, Hernando E, Cordon-Cardo C, Levine AJ. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A. 2007;104:16633-8. Cited in Pubmed; PMID 17921246.

Matushansky I, Hernando E, Edgar ME, Singer S, Schwartz GK, Maki RG, Cordon-Cardo C. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest. 2007;117(11):3248-57. Cited in Pubmed; PMID 17948129.

Hernando E, Charytonowicz E, Dudas ME, Menendez S, Mills J, Matushansky I, Socci ND, Behrendt N, Ma L, Maki RG, Pandolfi PP, Cordon-Cardo C. The Akt-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med. 2007;13(6):748-53. Cited in Pubmed; PMID 17496901.

Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007;445(7126):656-60. Cited in Pubmed; PMID 17251933.

Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martinez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW. The role of the chromobox protein CBX7 in lymphomagenesis. Proc Natl Acad Sci. 2007;104(13):5389-94. Cited in Pubmed; PMID 17374722.

Gonzalez S, Perez-Perez MM, Hernando E, Serrano M, Cordon-Cardo C. p73beta-mediated apoptosis requires p57kip2 induction and IEX-1 inhibition. Cancer Res. 2005;65(6):2186-92. Cited in Pubmed; PMID 15781630.

He L, Thomson JM, Hemann MT, Hernando-Monge E, Goodson S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM. A microRNA polycistron as a potential human oncogene. Nature. 2005;435(7043):828-33. Cited in Pubmed; PMID 15944707.

Michel L, Diaz-Rodriguez E, Narayan G, Hernando E, Murty V, Benezra R. Complete loss of the tumor suppressor Mad2 causes prematue cyclin B degradation and mitotic failure in human somatic cells. Proc Natl Acad Sci U S A. 2004;101(13):4459. Cited in Pubmed; PMID 15070740.

Hernando E, Nahle Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann MT, Michel L, Mittal V, Benezra R, Gerald W, Lowe SW, Cordon-Cardo C. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 2004;430:797-802. Cited in Pubmed; PMID 15306814.

Hemann MT, Fridman J, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet. 2003;33:396-400. Cited in Pubmed; PMID 12567186.

Juan G, Hernando E, Cordon-Cardo C. Separation of live cells in different phases of the cell cycle for gene expression analysis. Cytometry. 2002;49:170-5. Cited in Pubmed; PMID 12454980.

Selected Reviews

Hernando E. Aneuploidy Advantages? [commentary]. Science. 2008 Oct 31;322(5902):692-3. Cited in Pubmed; PMID 18974340. doi: 10.1126/science.1166151.

Hernando E. MicroRNAs and cancer: role in tumorigenesis, patient classification and therapy [review]. Clin Transl Oncol. 2007 Mar;9(3):155-60. Cited in Pubmed; PMID 17403626.

Organizational Associations

American Association Cancer Research

Selected Awards

Research Award, FASA-Renault, SA. 1998-1999
Ramon & Cajal Award, Spanish Ministry of Education, Spain, 2004
Whitehead Fellowship for Junior Faculty in Biomedical and Biological Sciences, 2007
American Cancer Society Scholar Award, 2008