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Research and Clinical Interests

Dr. Ghiso has a long-standing interest in the molecular pathogenesis of protein folding disorders, particularly Alzheimer's disease and unrelated hereditary conditions with comparable neurodegenerative pathology. Current research focuses in a) the importance of amyloid proteins and their post-translationally modified derivatives in the mechanism(s) of fibrillogenesis and dementia, b) their brain catabolism and clearance, and c) their significance as additional parameters of disease biomarkers.

Selected Publications

Rostagno A, Lashley T, Ng D, Meyerson J, Braendgaard H, Plant G, Bojsen-Moller M, Holton J, Frangione B, Revesz T, Ghiso J. Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease. J Neurol Sci. 2007 Jun 15;257(1-2):88-96. Cited in Pubmed; PMID 17374542.

Rostagno A, Ovodenko B, Neubert TA, Shetty V, Thomas S, Yang A, Liebmann J, Ghiso J, Ritch R. Proteomic analysis of exfoliation deposits. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1447-57. Cited in Pubmed; PMID 17389470.

Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006 Sep 22;313(5794):1781-4. Cited in Pubmed; PMID 16990547.

Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Bojsen-Moller M, Braendgaard H, Plant G, Holton J, Lal R, Revesz T, Frangione B. Genetic alterations of the BRI2 gene: familial British and Danish dementias. Brain Pathol. 2006 Jan;16(1):71-9. Cited in Pubmed; PMID 16612984.

Tomidokoro Y, Lashley T, Rostagno A, Neubert TA, Bojsen-Moller M, Braendgaard H, Plant G, Holton J, Frangione B, Revesz T, Ghiso J. Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan and Aβ) in the absence of compact plaques. J Biol Chem. 2005 Nov 4;280(44):36883-94. Cited in Pubmed; PMID 16091362.

Rostagno A, Tomidokoro Y, Lashley T, Ng D, Plant G, Holton J, Frangione B, Revesz T, Ghiso J. Chromosome 13 dementias. Cell Mol Life. 2005 Aug;62(16):1814-25. Cited in Pubmed; PMID 15968464.

Quist A, Doudevski I, Lin H, Azimova R, Ng D, Frangione B, Kagan B, Ghiso J, Lal R. Amyloid ion channels: a common structural link for protein-misfolding disease. Proc Natl Acad Sci U S A. 2005 Jul 26;1 02(30):10427-32. Cited in Pubmed; PMID 16020533.

Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, Rostagno A, Frangione B. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. J Biol Chem. 2004 Oct 29;279(44):45897-908. Epub 2004 Aug 20. Cited in Pubmed; PMID 15322125.

Rostagno A, Revesz T, Lashley T, Tomidokoro Y, Magnotti L, Braendgaard H, Plant G, Bojsen-Moller M, Holton J, Frangione B, Ghiso J. Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. J Biol Chem. 2002 Dec 20;277(51):49782-90. Cited in Pubmed; PMID 12388551.

Ghiso JA, Holton J, Miravalle L, Calero M, Lashley T, Vidal R, Houlden H, Wood N, Neubert TA, Rostagno A, Plant G, Revesz T, Frangione B. Systemic amyloid deposits in familial British dementia. J Biol Chem. 2001 Nov 23;276(47):4390-14. Cited in Pubmed; PMID 11557758.

Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec;106(12):1489-99. Cited in Pubmed; PMID 11120756.

Miravalle L, Tokuda T, Chiarle R, Giaccone G, Bugiani O, Tagliavini F, Frangione B, Ghiso J. Substitutions at codon 22 of Alzheimer's Abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. J Biol Chem. 2000 Sep 1;275(35):27110-6. Cited in Pubmed; PMID 10821838.

Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem. 2000 Jun 1;348 (Pt 2):359-65. Cited in Pubmed; PMID 10816430.

Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Moller M, Braendgaard H, Plant G, Ghiso J, Frangione B. decamer duplication in 3' region of BRI gene originates an amyloid peptide that's associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4920-5. Cited in Pubmed; PMID 10781099.

Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, Ghiso J. A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 1999 Jun 24;399(6738):776-81. Cited in Pubmed; PMID 10391242.

Selected Books

Cam J, Meyerson JL, Frangione B, Ghiso J, Rostagno A. Oligomeric assemblies of the Aβ dutch mutant induce the formation of nucleosomes in primary cerebral endothelial cells. In: Iqbal K, Winblad B, Avila J, editors. Alzheimer’s Disease: New Advances. Bologna, Italy: Medimond International Proceedings; 2007. pp. 397–402.

Rostagno A, Lal R, Ghiso J. Protein misfolding, aggregation, and fibril formation: Common features of cerebral and non-cerebral amyloid diseases. In: Dawbarn D, Allen S, editors. The Neurobiology of Alzheimer’s disease. Oxford: Oxford University Press; 2007. pp. 133-60.

Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Holton J, Plant G, Revesz T, Frangione B. Familial British and Danish Dementias. In: Sipe JD, editor. Amyloid Proteins. The β-sheet Conformation and Disease. Vol 2. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co; 2005. pp. 515-26.

Revesz T, Ghiso J, Plant G, Lashley T, Rostagno A, Frangione B, Holton JL. International Society for Neuropathology. In: Kalimo H, editor. Cerebrovascular Diseases. Pathology and Genetics. Vol. 5. Basel, Switzerland: International Society for Neuropathology; 2005. pp. 94-102.

Calero M, Ghiso J. Radiolabeling of Aβ peptides. In: Sigurdsson E, editor. Methods in Molecular Biology. Vol 299. New Jersey: Humana Press; 2005. pp. 325-48.

Calero M, Rostagno A, Frangione B, Ghiso J. Clusterin and Alzheimer’s disease. In: Harris R, editor. Subcellular Biochemistry: Alzheimer’s Disease. Vol 38. Berlin: Plenum Press / Kluwer; 2005. pp. 273-98.

Plant G, Ghiso J, Holton J, Frangione B, Revesz T. Familial and sporadic cerebral amyloid angiopathies associated with dementia and the BRI dementias. In: Esiri M, Lee V, Trojanowski J, editors. The Neuropathology of Dementia. Cambridge: Cambridge University Press; 2004. pp. 330-52.

Rostagno A, Ghiso J. Amyloidosis. In: Aminoff M, Daroff R, editors. Encyclopedia of the Neurological Sciences. Vol 1. San Diego: Academic Press; 2003. pp. 129-35.

Révész T, Ghiso J, Holton J, Frangione B. Inherited amyloidoses and neurodegeneration: familial British dementia and familial Danish dementia. In: Dickson D, editor. Neurodegeneration: The molecular pathology of dementia and movements disorders. Basel, Switzerland: International Society of Neuropathology; 2003. pp. 380-5.

Matsubara E, Shoji M, Murakami T, Abe K, Frangione B, Ghiso J. Platelet microparticles as carriers of soluble Alzheimer’s amyloid β (sAβ). In: De la Torre J, Kalaria R, Nakajima K, and Nagata K, editors. Alzheimer’s disease: Vascular Etiology and Pathology. Ann. N.Y. Acad. Sci. Vol 977. Malden, MA: Blackwell Publishing Inc; 2002. pp. 340-8.

Ghiso J, Révész T, Rostagno A, Vidal R, Plant G, Frangione B. Familial British Dementia. In: Iqbal K, Sisodia SS, Wimblad B, editors. Alzheimer’s disease: Advances in Etiology, Pathogenesis and Therapeutics. Chichester, England: John Wiley & Sons; 2001. pp. 487-94.

Vidal R, Révész T, Rostagno A, Bek T, Braendgaard H, Plant G, Ghiso J, Frangione B. A decamer duplication in the BRI gene originates a de novo amyloid peptide that causes dementia in a Danish kindred. In: Iqbal K, Sisodia SS, Winblad B, editors. Alzheimer’s disease: Advances in etiology, pathogenesis and therapeutics. Chichester, England: John Wiley & Sons; 2001. pp. 507-13.

Zlokovic B, Ghiso J, Frangione B. Vascular transport of Alzheimer’s amyloid β peptides and apolipoproteins. In: Verbeek M, de Wall R, and Vinters H, editors. Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders. Dordrecht, Netherlands: Kluwer Academic Publishers; 2000. pp. 325-26.

Ghiso J, Vidal R, Rostagno A, Miravalle L, Holton J, Révész T, Plant G, Frangione B. Amyloidogenesis in Familial British Dementia Is Associated with a Genetic Defect on Chromosome 13. In: Growdon J, Wurtman R, Corkin S, Nitsch, R, editors. The molecular Basis of Dementia. Ann. NY Acad Sci. Vol 920. Malden, MA: Blackwell Publishing Inc; 2000. pp. 84-92.

Ghiso J, Vidal R, Rostagno A, Mead S, Révész T, Plant G, Frangione B. A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia. In: Kalaria R, Ince P, editors. Vascular Factors in Alzheimer’s Disease. Ann NY Acad Sci. Vol 903. Malden, MA: Blackwell Publishing Inc; 2000. pp. 129-37.

Organizational Associations

Society for Neuroscience; The New York Academy of Sciences; The Protein Society; The New York University Bellevue Psychiatric Society; Associate Editor Journal of Alzheimer’s Disease; Editorial Board Member The Journal of Biological Chemistry; Editorial Board Member Current Alzheimer Research; Editorial Board Member Molecular Neurodegeneration

Selected Awards

2000 New York City Leadership Fellow, American Heart Association Heritage Affiliate
2000 Zenith Award, Alzheimer Association
1997 New Investigator Development Award. American Heart Association, New York City Affiliate

© 2008 NYU Department of Pathology