Hodaka Fujii, M.D., Ph.D.
Assistant Professor of Pathology
Immunology / Signal transduction; Function and development of lymphocytes
fujiih01@nyumc.org, (212) 263 8514
Fax: (212) 263 8179
550 First Avenue, MSB 126A, New York, NY 10016
Research and Clinical Interests
Dr. Fujii's interests are (1) to develop novel methodologies to analyze signal transduction from immune receptors and (2) to analyze function and development of lymphocytes. His lab is currently investigating mechanisms of signal transduction from receptors of cytokines and other immune receptors and function of a novel activation-induced gene in T cell function and effector differentiation. His other clinical interests include SCID and hematological malignancies.
Selected Publications
Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V. Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell. 2007 Nov 2;131(3):492-504. Cited in Pubmed; PMID 17981117. doi: 10.1016/j.cell.2007.09.013.
Hoshino A, Fujii H. Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. FEBS Lett. 2007;581:975-80. Cited in Pubmed; PMID 17300783.
Fujii, H. Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Biochem Biophys Res Commun. 2007;354:825-9. Cited in Pubmed; PMID 17266928.
Hoshino A, Hirst JA, Fujii H. Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. J Biol Chem. 2007;282:17706-11. Cited in Pubmed; PMID 17446165.
Hoshino A, Fujii H. Temporal regulation of Stat5 activity determines cell differentiation program. Biochem Biophys Res Commun. 2007;358:914-19. Cited in Pubmed; PMID 17511959.
Hoshino A, Fujii H. Stress-induced nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase (KBL). Cell Stress Chaperones. 2007;12:186-181. Cited in Pubmed; PMID 17688197.
Hoshino A, Saint Fleur S, Fujii H. Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain. Biochem Biophys Res Commun. 2006;346:1062-6. Cited in Pubmed; PMID 16782051.
Hoshino A, Matsumura S, Kondo K, Hirst JA, Fujii H. Inducible translocation trap: a system for detecting inducible nuclear translocation. Mol Cell. 2004;15:153-9. Cited in Pubmed; PMID 15225556.
Tucker SN, Jessup HK, Fujii H, Wilson CB. Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic IEL and NK1.1+ T cells. Blood. 2002;99:513-19. Cited in Pubmed; PMID 11781232.
Gilmour KC, Fujii H, Cranston T, Davies EG, Kinnon C, Gaspar HB. Defective expression of the interleukin-2/interleukin-15 receptor β subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency. Blood. 2001;98:877-79. Cited in Pubmed; PMID 11468191.
Tsujino S, Di Santo JD, Takaoka A, McKernan TL, Noguchi S, Taya C, Yonekawa H, Saito T, Taniguchi T, Fujii H. Differential requirement of the cytoplasmic subregions of γc in T cell development and function. Proc Natl Acad Sci U S A. 2000;97:10514-9. Cited in Pubmed; PMID 10962026.
Tsujino S, Miyazaki T, Kawahara A, Maeda M, Taniguchi T, Fujii H. Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor γc chain in the Jak3-independent signal transduction. Genes Cells. 1999;4:363-73. Cited in Pubmed; PMID 10421845.
Fujii H, Ogasawara K, Otsuka H, Suzuki M, Yamamura KI, Yokochi T, Miyazaki T, Suzuki H, Mak TW, Taki S, Taniguchi T. Functional dissection of the cytoplasmic subregions of the IL-2 receptor βc chain in primary lymphocyte populations. EMBO J. 1998;17:6551-7. Cited in Pubmed; PMID 9822600.
Fujii H, Nakagawa Y, Schindler U, Kawahara A, Mori H, Gouilleux F, Groner B, Ihle JN, Minami Y, Miyazaki T, Taniguchi T. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc Natl Acad Sci U S A. 1995;92:5482-6. Cited in Pubmed; PMID 7777534.
Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, Taniguchi T. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 1994;266:1045-7. Cited in Pubmed; PMID 7973659.
Organizational Associations
American Society for Biochemistry and Molecular Biology; The American Association of Immunologists; Molecular Biology Society of Japan; Japanese Society of Immunology
Selected Awards
2007 The American Association of Immunologists Junior Faculty Travel Award
1996 Award of Tokyo University Medical Association
1995 The Kato Memorial Bioscience Grant for International Research Fellowship
1995 - 1998 Research Fellowship of the Japan Society for the Promotion of Science
