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Research and Clinical Interests

Dr. Feske's research is focused on understanding the mechanisms underlying calcium signaling pathways in lymphocytes and the role they play for immune function in vitro and in vivo. Important molecules in this pathway, the CRAC calcium channel protein Orai1 and its activator Stim1 were recently discovered by his and other labs. The Feske lab studies the regulation of the STIM1-Orai1 pathway and explores its role for immune function in health and disease using human and animal models. Read more about research in the Feske Lab.

See also NYU Langone Medical Center's Research Forefronts interview with Dr. Feske on calcium movements.

Selected Publications

McCarl CA, Picard C, Kawasaki T, Khalil S, Röther J, Papolos A, Hivroz C, Le Deist F, Kutok J, Plogmann K, Ehl S, Kirschner J, Rao A, Fischer A, Feske S. ORAI1 deficiency and lack of store-operated calcium entry cause immunodeficiency, myopathy and ectodermal dysplasia. J Allergy Clin Immunol. Forthcoming 2009.

Lur G, Haynes LP, Prior IA, Gerasimenko OV, Feske S, Petersen OH, Burgoyne RD, Tepikin AV. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Curr Biol. 2009 Oct 13;19(19):1648-53. Epub 2009 Sep 17. Cited in Pubmed; PMID 19765991. doi: 10.1016/j.cub.2009.07.072.

Kawasaki T, Lange I, Feske S. A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun. 2009 Jul 17;385(1):49-54. Epub 2009 May 9. Cited in Pubmed; PMID 19433061. doi: 10.1016/j.bbrc.2009.05.020.

Picard C, McCarl CA, Papolos A, Khalil S, Lüthy K, Hivroz C, LeDeist F, Rieux-Laucat F, Rechavi G, Rao A, Fischer A, Feske S. STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity. N Engl J Med. 2009 May 7;360(19):1971-80. Cited in Pubmed; PMID 19420366.

Bergmeier W, Oh-Hora M, McCarl CA, Roden RC, Bray PF, Feske S. R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood. 2008 Oct;Epub 2008 Oct 24. Cited in Pubmed; PMID 18952890. doi: 10.1182/blood-2008-08-174516.

Oh-hora M, Yamashita M, Hogan PG, Sharma S, Lamperti E, Chung W, Prakriya M, Feske S, Rao A. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol. 2008;9:432-43. Epub 2008 Mar 9. Cited in Pubmed; PMID 18327260.

Gwack Y, Feske S, Srikanth S, Hogan P, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007;42:145-56. Cited in Pubmed; PMID 17572487.

Feske, S. Calcium signals in lymphocyte activation and disease. Nature Reviews Immunology. 2007;7:690-702. Cited in Pubmed; PMID 17703229.

Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems D, Hogan PG, Rao A. Orai1 is the predominant mediator of store operated Ca2+ entry in T cells. J Biological Chem. J Biological Chem. 2007;282:16232-43. Cited in Pubmed; PMID 17293345.

Feske S*, Gwack Y*, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006;441:179-85. Cited in Pubmed; PMID 16582901.

Prakriya M*, Feske S*, Gwack Y*, Srikanth S, Rao A, Hogan P. Orai1 is an essential component of the CRAC channel pore. Nature. 2006;443:230-3. Cited in Pubmed; PMID 16921383.

Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth A, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies novel regulators of Ca2+/ calcineurin/ NFAT signaling: DYRK, STIM and cathepsin B. Nature. 2006;441:646-50. Cited in Pubmed; PMID 16511445.

Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers cellular wound healing, endocytosis and endosomolysis to release granzyme B to the cytosol. Immunity. 2005;23:249-62. Cited in Pubmed; PMID 16169498.

Feske S*, Prakriya M*, Rao A, Lewis R. A severe defect in CRAC Ca2+ channel function associated with altered K+ channel gating properties in T cells from immunodeficient patients. J Exp Med. 2005;202:651-62. Cited in Pubmed; PMID 16147976.

Feske S, Müller JM, Graf D, Kroczek RA, Dräger R, Niemeyer C, Baeuerle PA, Peter HH, Schlesier M. Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings. Eur J Immunology. 1996;26:2119-26. Cited in Pubmed; PMID 8814256.

Selected Books and Reviews

Feske S. ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond. Immunol Rev. 2009;231:189-209. Cited in Pubmed; PMID 19754898. doi: 10.1111/j.1600-065X.2009.00818.x.

Feske S, Rao A, Hogan P. The Ca2+ - calcineurin - NFAT signalling pathway. In: Krebs J, Michalak M, editors. Calcium, a Matter of Life or Death. New Comprehensive Biochemistry. Amsterdam: Elsevier; 2007.

Feske S, Peter HH. Severe Combined Immunodeficiency (SCID). In: NORD Guide to Rare Disorders, editor. National Organization for Rare Disorders (NORD). NORD Guide to Rare Disorders. Philadelphia: Lippincott, Williams & Wilkins; 2002.

Organizational Associations

American Association of Immunologists (AAI); Deutsche Gesellschaft für Immunologie (DGfI; German Immunology Society); Pluto Society (American Association of University Pathologists); Biophysical Society

Selected Awards

2007 Georges-Koehler Award of the German Immunology Society (DGfI)
2000 - 2003 Research Fellowship, Cancer Research Institute, New York
1998 - 2000 Research Fellowship, German Research Foundation (DFG), Germany
1998 Hans-Hench Foundation Fellowship, Germany
1996 Ludwig-Heilmeyer Award for best medical degree thesis, University of Freiburg Medical School, Germany
1996 M.D. with summa cum laude

Additional Information

Research Profile