Stefan Feske, M.D.
Assistant Professor of Pathology
Experimental Pathology, Immunology, Pathobiology / T cell activation, immunity and development, calcium channels
stefan.feske@med.nyu.edu, (212) 263 9066
Fax: (212) 263 8211
522 First Avenue, SRB 316, New York, NY 10016
Research and Clinical Interests
Dr. Feske's research is focused on understanding the mechanisms underlying calcium signaling pathways in lymphocytes and the role they play for immune function in vitro and in vivo. Important molecules in this pathway, the CRAC calcium channel protein Orai1 and its activator Stim1 were recently discovered by his and other labs. The Feske lab studies the regulation of the STIM1-Orai1 pathway and explores its role for immune function in health and disease using human and animal models.
Selected Publications
Oh-Hora M, Yamashita M, Hogan PG, Sharma S, Lamperti E, Chung W, Prakriya M, Feske S, Rao A. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol. 2008;9:432-43. Epub 2008 Mar 9. Cited in Pubmed; PMID 18327260.
Feske, S. Calcium signals in lymphocyte activation and disease. Nature Reviews Immunology. 2007;7:690-702. Cited in Pubmed; PMID 17703229.
Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems D, Hogan PG, Rao A. Orai1 is the predominant mediator of store operated Ca2+ entry in T cells. J Biological Chem. J Biological Chem. 2007;282:16232-43. Cited in Pubmed; PMID 17293345.
Gwack Y, Feske S, Srikanth S, Hogan P, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007;42:145-56. Cited in Pubmed; PMID 17572487.
Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth A, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies novel regulators of Ca2+/ calcineurin/ NFAT signaling: DYRK, STIM and cathepsin B. Nature. 2006;441:646-50. Cited in Pubmed; PMID 16511445.
Feske S*, Gwack Y*, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006;441:179-85. Cited in Pubmed; PMID 16582901.
Prakriya M*, Feske S*, Gwack Y*, Srikanth S, Rao A, Hogan P. Orai1 is an essential component of the CRAC channel pore. Nature. 2006;443:230-3. Cited in Pubmed; PMID 16921383.
Feske S*, Prakriya M*, Rao A, Lewis R. A severe defect in CRAC Ca2+ channel function associated with altered K+ channel gating properties in T cells from immunodeficient patients. J Experimental Medicine. 2005;202:651-62. Cited in Pubmed; PMID 16147976.
Cianferoni A, Massaad M, Feske S, Gallego L, de la Fuente M, Ramesh N, Geha RS. Defective nuclear translocation of Erk and NFAT underlie deficient IL-2 gene expression in Wiskott Aldrich syndrome. J Allergy Clin Immunol. 2005;116:1364-71. Cited in Pubmed; PMID 16337472.
Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers cellular wound healing, endocytosis and endosomolysis to release granzyme B to the cytosol. Immunity. 2005;23:249-62. Cited in Pubmed; PMID 16169498.
Kumar L, Feske S, Geha R. The lck binding microdomain of SLP-76 is essential for T cell development and function. Proc Natl Acad Sci U S A. 2005;102:19063-8. Cited in Pubmed; PMID 16354835.
Feske S, Müller JM, Graf D, Kroczek RA, Dräger R, Niemeyer C, Baeuerle PA, Peter HH, Schlesier M. Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings. Eur J Immunology. 1996;26:2119-26. Cited in Pubmed; PMID 8814256.
Selected Books
Feske S, Rao A, Hogan P. The Ca2+ - calcineurin - NFAT signalling pathway. In: Krebs J, Michalak M, editors. Calcium, a Matter of Life or Death. New Comprehensive Biochemistry. Amsterdam: Elsevier; 2007.
Feske S, Peter HH. Severe Combined Immunodeficiency (SCID). In: NORD Guide to Rare Disorders, editor. National Organization for Rare Disorders (NORD). NORD Guide to Rare Disorders. Philadelphia: Lippincott, Williams & Wilkins; 2002.
Organizational Associations
American Association of Immunologists (AAI); Deutsche Gesellschaft für Immunologie (DGfI; German Immunology Society)
Selected Awards
2007 Georges-Koehler Award of the German Immunology Society (DGfI)
2000 - 2003 Research Fellowship, Cancer Research Institute, New York
1998 - 2000 Research Fellowship, German Research Foundation (DFG), Germany
1998 Hans-Hench Foundation Fellowship, Germany
1996 Ludwig-Heilmeyer Award for best medical degree thesis, University of Freiburg Medical School, Germany
1996 M.D. with summa cum laude
