Adrian Erlebacher, M.D., Ph.D.
Assistant Professor of Pathology
Program in Developmental Genetics
NYU Cancer Institute
Co-Director, Pathobiology Training Program
Experimental Pathology, Immunology, Pathobiology / Immunobiology of pregnancy, peripheral immune tolerance, immune regulation
Adrian.Erlebacher@nyumc.org, (212) 263 8926 , (212) 263 0406
Fax: (212) 263 8211
522 First Avenue, SRB 311, New York, NY 10016
Research and Clinical Interests
My laboratory is interested in how the fetus escapes rejection by the maternal immune system during pregnancy, which is one of the outstanding problems in transplantation immunology. This problem provides a unique inroad into broad issues relevant to peripheral immune tolerance, autoimmunity, tumor immunology, leukocyte trafficking, and clinical disorders of pregnancy.
Selected Publications
Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest. 2007 May;117(5):1399-1411. Epub 2007 Apr 19. Cited in Pubmed; PMID 17446933.
Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. An in vivo model of human placentation reveals cytotrophoblast induction of arterial apoptosis and lymphangiogenesis. J Clin Invest. 2006 Oct;116(10):2643-52. Epub 2006 Sep 21. Cited in Pubmed; PMID 16998586.
ayade C, Fang Y, Black GP, V A P Jr, Erlebacher A, Croy BA. Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells. J Leukoc Biol. 2005 Dec;78(6):1347-55. Epub 2005 Oct 4. Cited in Pubmed; PMID 16204645.
Erlebacher A, Price KA, Glimcher LH. Maintenance of mouse trophoblast stem cell proliferation by TGF-/activin. Dev Biol. 2004;275:158-69. Cited in Pubmed; PMID 15464579.
Erlebacher A, Zhang D, Parlow AF, Glimcher LH. Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest. 2004;114:39-48. Cited in Pubmed; PMID 15232610.
Erlebacher A, Lukens AK, Glimcher LH. Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo. Proc Natl Acad Sci U S A. 2002 Dec 24;99:16940-45. Cited in Pubmed; PMID 12486249.
Erlebacher A. Why isn't the fetus rejected? Curr Opin Immunol. 2001 Oct;13(5):590-3. Cited in Pubmed; PMID 11544009.
Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. Inhibition of TGF- receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct;126(19):4267-79. Cited in Pubmed; PMID 10477295.
Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. Osteoblastic responses to TGF- during bone remodeling. Mol Biol Cell. 1998 Jul;9(7):1903-18. Cited in Pubmed; PMID 9658179.
Erlebacher A, Derynck R. Increased expression of TGF-2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996;132:195-210. Cited in Pubmed; PMID 8567723.
Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. Toward a molecular understanding of skeletal development. Cell. 1995 Feb 10;80:371-8. Cited in Pubmed; PMID 7859279.
Barad M, Erlebacher A, McGinnis W. Despite expression in embryonic visceral mesoderm, H2.0 is not essential for Drosophila visceral muscle morphogenesis. Dev Genet. 1991;12(3):206-11. Cited in Pubmed; PMID 1678322.
Organizational Associations
American Association of Immunologists
Selected Awards
1986 Phi Beta Kappa, Yale University
1988 Graduated Summa cum laude, Yale University
1988-1989 Henry Fellowship, Cambridge University, England
1999-2004 Mentored Clinical Scientist Development Award (K08): "Mechanisms of maternal immune tolerance towards the allogeneic fetus"
2005 Presented the President's Symposium invited lecture at the Society for the Study of Reproduction annual meeting, Quebec City, Canada
