People

Research and Clinical Interests

My laboratory is interested in how the fetus escapes rejection by the maternal immune system during pregnancy, which is one of the outstanding problems in transplantation immunology. This problem provides a unique inroad into broad issues relevant to peripheral immune tolerance, autoimmunity, tumor immunology, leukocyte trafficking, and clinical disorders of pregnancy. A more detailed overview about current research in the Erlebacher Lab is available on the Erlebacher Lab website.

Selected Publications

Nancy P, Tagliani E, Tay CS, Asp P, Levy DE, Erlebacher A.. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012 Jun 8;336(6086):1317-1321. Cited in Pubmed; PMID 22679098. doi: 10.1126/science.1220030. PMCID: PMC3727649.

Tagliani E, Shi C, Nancy P, Tay CS, Pamer EG, Erlebacher A. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J Exp Med. 2011 Aug 29;208(9):1901-16. Cited in Pubmed; PMID 21825019. doi: 10.1084/jem.20110866. PMCID: PMC3171096 [Available on 2012/2/29].

Gaziel-Sovran A, Segura MF, Di Micco R, Collins MK, Hanniford D, Vega-Saenz de Miera E, Rakus JF, Dankert JF, Shang S, Kerbel RS, Bhardwaj N, Shao Y, Darvishian F, Zavadil J, Erlebacher A, Mahal LK, Osman I, Hernando E. miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell. 2011 Jul 12;20(1):104-118. Cited in Pubmed; PMID 21741600. doi: 10.1016/j.ccr.2011.05.027. PMCID: PMC3681522.

McCloskey ML, Curotto de Lafaille MA, Carroll MC, Erlebacher A. Acquisition and presentation of follicular dendritic cell–bound antigen by lymph node–resident dendritic cells. J Exp Med. 2011 Jan 17;208(1):135-148. Cited in Pubmed; PMID 21173103. doi: 10.1084/jem.20100354. PMCID: PMC3023135.

Collins MK, Tay CS, Erlebacher A. Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice. J Clin Invest. 2009 Jul;119(7):2062-73. Cited in Pubmed; PMID 19546507. doi: 10.1172/JCI38714. PMCID: PMC2701881.

Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest. 2007 May;117(5):1399-1411. Cited in Pubmed; PMID 17446933. PMCID: PMC1849983.

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct;116(10):2643-52. Cited in Pubmed; PMID 16998586.

Tayade C, Fang Y, Black GP, Paffaro VA Jr, Erlebacher A, Croy BA. Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells. J Leukoc Biol. 2005 Dec;78(6):1347-55. Cited in Pubmed; PMID 16204645.

Erlebacher A, Zhang D, Parlow AF, Glimcher LH. Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest. 2004;114:39-48. Cited in Pubmed; PMID 15232610.

Erlebacher A, Price KA, Glimcher LH. Maintenance of mouse trophoblast stem cell proliferation by TGF-β/activin. Dev Biol. 2004;275:158-69. Cited in Pubmed; PMID 15464579.

Erlebacher A, Lukens AK, Glimcher LH. Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo. Proc Natl Acad Sci U S A. 2002 Dec 24;99:16940-45. Cited in Pubmed; PMID 12486249.

Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. Inhibition of TGF- receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct;126(19):4267-79. Cited in Pubmed; PMID 10477295.

Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. Osteoblastic responses to TGF- during bone remodeling. Mol Biol Cell. 1998 Jul;9(7):1903-18. Cited in Pubmed; PMID 9658179.

Erlebacher A, Derynck R. Increased expression of TGF-2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996;132:195-210. Cited in Pubmed; PMID 8567723. PMCID: PMC2120709.

Barad M, Erlebacher A, McGinnis W. Despite expression in embryonic visceral mesoderm, H2.0 is not essential for Drosophila visceral muscle morphogenesis. Dev Genet. 1991;12(3):206-11. Cited in Pubmed; PMID 1678322.

Selected Reviews

Erlebacher A. Mechanisms of T cell tolerance towards the allogeneic fetus. Nature Reviews Immunology. 2013 Jan;13:23-33. doi: 10.1038/nri3361.

Erlebacher A. Immunology of the maternal-fetal interface. Annu Rev Immunol. 2013;31:387-411. Cited in Pubmed; PMID 23298207. doi: 10.1146/annurev-immunol-032712-100003.

Erlebacher A. T cell behavior at the maternal-fetal interface. Annu Rev. Immunol.. 2013;31:387-411. doi: 10.1146/annurev-immunol-032712-100003.

Schug T.T., Erlebacher A., Leibowitz S., Ma L., Muglia L.J., Rando O.J., Rogers J.M., Romero R., Saal F.S., Wise D.L.. Fetal programming and environmental exposures: implications for prenatal care and preterm birth. Ann NY Acad Sci.. 2012;1276:37-46. doi: 10.1111/nyas.12003.

Tagliani E, Erlebacher A. Dendritic cell function at the maternal-fetal interface. Expert Rev Clin Immunol. 2011 Sep;7(5):593-602. Cited in Pubmed; PMID 21895472. doi: 10.1586/eci.11.52.

Erlebacher A. Strangers no more: uterine NK cell recognition of the placenta in mice. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4267-8. Cited in Pubmed; PMID 21372266. doi: 10.1073/pnas.1101509108. PMCID: PMC3060254.

Erlebacher A. Immune surveillance of the maternal/fetal interface: controversies and implications (review). Trends Endocrinol Metab. 2010 Jul;21(7):428-34. Cited in Pubmed; PMID 20304670. doi: 10.1016/j.tem.2010.02.003. PMCID: PMC2892024.

Organizational Associations

American Association of Immunologists

Selected Awards

1986 Phi Beta Kappa, Yale University
1988 Graduated Summa cum laude, Yale University
1988-1989 Henry Fellowship, Cambridge University, England
1999-2004 Mentored Clinical Scientist Development Award (K08): "Mechanisms of maternal immune tolerance towards the allogeneic fetus"
2005 Presented the President's Symposium invited lecture at the Society for the Study of Reproduction annual meeting, Quebec City, Canada