Brian D. Dynlacht, Ph.D.
Professor of Pathology
Director, Genomics Program NYU Cancer Institute
Molecular Oncology / Cancer, transcription, cell cycle, centrosome biology, genomics
dynlab01@nyumc.org, (212) 263 6162
Fax: (212) 263 6157
522 First Avenue, SRB 11th Floor, New York, NY 10016
Research and Clinical Interests
The Dynlacht laboratory uses a combination of biochemical, genomic, and computational methods to dissect the role that the retinoblastoma tumor suppressor protein (pRb) family plays in effecting chromatin modifications that underlie gene repression during cell cycle progression and myogenic differentiation. The laboratory also focuses on understanding the molecular controls that govern centrosome duplication, which plays a pivotal role in cell cycle progression and mitosis.
Selected Publications
Tsang WY, Bossard C, Khanna H, Peränen J, Swaroop A, Malhotra V, Dynlacht BD. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev Cell. 2008 Aug;15(2):187-97.
Spektor A, Tsang WY, Khoo D, Dynlacht BD. Cep97 and CP110 Suppress a Cilia Assembly Program. Cell. 2007 Aug 24;678-90.
Tsang WY, Wang L, Chen Z, Sánchez I, Dynlacht BD. SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression. J Cell Biol. 2007 Aug 13;178(4):621-33.
Lerman G, McQuown J, Blais A,Dynlacht BD, Chen G, Mishra B. Functional genomics via multiscale analysis: application to gene expression and ChIP-on-chip data. Bioinformatics. 2007 Feb 1;23(3):314-20.
Tsang WY, Spektor A, Luciano DJ, Indjeian VB, Chen Z, Salisbury JL, Sánchez I, Dynlacht BD. CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability. Mol Biol Cell. 2006 Aug;17(8):3423-34.
Balciunaite E, Spektor A, Lents NH, Cam H, Te Riele H, Scime A, Rudnicki MA, Young R, Dynlacht BD. Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol Cell Biol. 2005 Sep;25(18):8166-78.
Blais A, Tsikitis M, Acosta-Alvear D, Sharan R, Kluger Y, Dynlacht BD. An initial blueprint for myogenic differentiation. Genes Dev. 2005 Mar 1;19(5):553-69.
Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell. 2002 Dec;2(6):463-72.
Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002 Sep;3(3):339-50.
Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 2002 Apr 15;16(8):933-47.
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 2002 Jan 15;16(2):245-56.
Ross JF, Näär A, Cam H, Gregory R, Dynlacht BD. Active repression and E2F inhibition by pRB are biochemically distinguishable. Genes Dev. 2001 Feb 15;15(40:392-7.
Takahashi Y, Rayman JB, Dynlacht BD. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 2000 Apr 1;14(7):804-16.
Ross JF, Liu X, Dynlacht BD. Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein. Mol Cell. 1999 Feb;3(2):195-205.
Cai K, Dynlacht BD. Activity and nature of p21(WAF1) complexes during the cell cycle. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12254-9.
Organizational Associations
Editorial Board, Cell Death and Differentiation; Ad Hoc Editor, Proceedings of the National Academy of Sciences; Member, NIH MGB study section
Selected Awards
1987 Yale University Summa cum Laude and Distinction in the Major of Molecular Biophysics and Biochemistry
1992 Oncogene Science Award for Outstanding Research in Transcription
1992 PhD dissertation selected to represent University of California at Berkeley in International Dissertation Competition
1993-95 Damon Runyon-Walter Winchell Cancer Fund Fellow
1996-1997 Kenneth G. and Elaine A. Langone Damon Runyon Scholar Award
1996-1997 Pew Scholar in the Biomedical Sciences
1999 Presidential Early Career Award for Scientists and Engineers (PECASE)
2005-present Irma T. Hirschl Trust Career Award
