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Research and Clinical Interests

The Dynlacht laboratory uses a combination of biochemical, genomic, and computational methods to dissect the role that the retinoblastoma tumor suppressor protein (pRb) family plays in effecting chromatin modifications that underlie gene repression during cell cycle progression and myogenic differentiation. The laboratory also focuses on understanding the molecular controls that govern centrosome duplication, which plays a pivotal role in cell cycle progression and mitosis.

Selected Publications

Tsang WY*, Spektor A*, Vijayakumar S, Bista BR, Sanchez I, Duensing S, Dynlacht BD. Cep76, a Centrosomal Protein that Specifically Restrains Centriole Reduplication. Dev Cell. 2009 May 19;16(5):649–60. doi: 10.1016/j.devcel.2009.03.004.

Asp P, Acosta-Alvear D, Tsikitis M, van Oevelen C, Dynlacht BD. E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev. 2009 Jan 1;23:37-53. doi: 10.1101/gad.1727309.

van Oevelen C, Wang J, Asp P, Yan Q, Kaelin WG Jr, Kluger Y, Dynlacht BD. A role for mammalian Sin3 in permanent gene silencing. Mol Cell. 2008 Nov 7;32(3):359-70. doi: 10.1016/j.molcel.2008.10.015.

Tsang WY, Bossard C, Khanna H, Peränen J, Swaroop A, Malhotra V, Dynlacht BD. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev Cell. 2008 Aug;15(2):187-97. Cited in Pubmed; PMID 18694559. doi: 10.1016/j.devcel.2008.07.004.

Spektor A, Tsang WY, Khoo D, Dynlacht BD. Cep97 and CP110 Suppress a Cilia Assembly Program. Cell. 2007 Aug 24;678-90.

Tsang WY, Wang L, Chen Z, Sánchez I, Dynlacht BD. SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression. J Cell Biol. 2007 Aug 13;178(4):621-33.

Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell. 2007 Jul 6;27(1):53-66.

Lerman G, McQuown J, Blais A, Dynlacht BD, Chen G, Mishra B. Functional genomics via multiscale analysis: application to gene expression and ChIP-on-chip data. Bioinformatics. 2007 Feb 1;23(3):314-20.

Tsang WY, Spektor A, Luciano DJ, Indjeian VB, Chen Z, Salisbury JL, Sánchez I, Dynlacht BD. CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability. Mol Biol Cell. 2006 Aug;17(8):3423-34.

Balciunaite E, Spektor A, Lents NH, Cam H, Te Riele H, Scime A, Rudnicki MA, Young R, Dynlacht BD. Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol Cell Biol. 2005 Sep;25(18):8166-78.

Blais A, Tsikitis M, Acosta-Alvear D, Sharan R, Kluger Y, Dynlacht BD. An initial blueprint for myogenic differentiation. Genes Dev. 2005 Mar 1;19(5):553-69.

Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell. 2002 Dec;2(6):463-72.

Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002 Sep;3(3):339-50.

Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 2002 Apr 15;16(8):933-47.

Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 2002 Jan 15;16(2):245-56.

Organizational Associations

Editorial Board, Cell Death and Differentiation; Ad Hoc Editor, Proceedings of the National Academy of Sciences; Member, NIH MGB study section

Selected Awards

1987 Yale University Summa cum Laude and Distinction in the Major of Molecular Biophysics and Biochemistry
1992 Oncogene Science Award for Outstanding Research in Transcription
1992 PhD dissertation selected to represent University of California at Berkeley in International Dissertation Competition
1993-1995 Damon Runyon-Walter Winchell Cancer Fund Fellow
1995-1997 Kenneth G. and Elaine A. Langone Damon Runyon Scholar Award
1998-2002 Pew Scholar in the Biomedical Sciences
1998-2003 Presidential Early Career Award for Scientists and Engineers (PECASE)
2005-present Irma T. Hirschl Trust Career Award