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Research and Clinical Interests

Adaptive immunity requires a network of cell-cell interactions that are orchestrated by chemokines, adhesion molecules and antigen receptors. We study the biology of T lymphocyte activation and differentiation using integrated in vitro and in vivo microscopic observation and mouse genetics. Specific contexts include vaccination, autoimmunity, asthma, bacterial and viral infection and cancer immunotherapy.

Selected Publications

Dustin ML, Starr T, Coombes D, Majeau G, Meier W, Hochman P, Douglass A, Vale RD, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2, CD58Fc chimera (Alefacept) and CD16 mediated cell adhesion. J Biol Chem. 2007 Nov 30;282(48):34748-57. Epub 2007 Oct 2. Cited in Pubmed; PMID 17911103.

Skokos D, Shakhar G, Varma R, Waite JC, Cameron TO, Lindquist RL, Schwickert T, Nussenzweig MC, Dustin ML. Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol. 2007;8:835-44. Cited in Pubmed; PMID 17632517.

Schwickert TA, Lindquist RL, Shakhar G, Livshits G, Skokos D, Kosco-Vilbois MH, Dustin ML, Nussenzweig MC. In vivo imaging of germinal centres reveals a dynamic open structure. Nature. 2007;446:83-7. Cited in Pubmed; PMID 17268470.

Velazquez P, Waite JC, Dustin ML. Dynamics of host defense: the view at the front lines. Nat Immunol. 2007;8:1153-57. Cited in Pubmed; PMID 17952039.

Sims TN, Soos TJ, Xenias HS, Dubin-Thaler B, Hofman JM, Waite JC, Cameron TO, Thomas VK, Varma R, Wiggins CH, Sheetz MP, Littman DR, Dustin ML. Opposing Effects of PKCtheta and WASp on Symmetry Breaking and Relocation of the Immunological Synapse. Cell. 2007;129:773-85. Cited in Pubmed; PMID 17512410.

Huang JH, Cardenas-Navia LI, Caldwell CC, Plumb TJ, Radu CG, Rocha PN, Wilder T, Bromberg JS, Cronstein BN, Sitkovsky M, Dewhirst MW, Dustin ML. Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol. 2007;178:7747-55. Cited in Pubmed; PMID 17548612.

Demond AL, Starr T, Dustin ML, Groves JT. Control of antigen presentation with a photoreleasable agonist Peptide. J Am Chem Soc. 2006;128:15354-15355. Cited in Pubmed; PMID 17131984.

Anikeeva N, Lebedeva T, Clapp AR, Goldman ER, Dustin ML, Mattoussi H, Sykulev Y. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A. 2006;103:16846-51. Cited in Pubmed; PMID 17077145.

Varma R, Campi G, Yokosuka T, Saito T, Dustin ML. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity. 2006;25:117-27. Cited in Pubmed; PMID 16860761.

Tadokoro CE, G. Shakhar G, S. Shen S, Y. Ding Y, A.C. Lino AC, Maraver A, Lafaille JJ, Dustin ML. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med. 2006;203:505-511. Cited in Pubmed; PMID 16533880.

Kim JV, Dustin ML. Innate response to focal necrotic injury inside the blood-brain barrier. J Immunol. 2006;177:5269-5277. Cited in Pubmed; PMID 17015712.

Mossman KD, Campi G, Groves JT, Dustin ML. Altered TCR signaling from geometrically repatterned immunological synapses. Science. 2005;310:1191-1193. Cited in Pubmed; PMID 16293763.

Tseng SY, Liu M, Dustin ML. CD80 Cytoplasmic Domain Controls Localization of CD28, CTLA-4, and Protein Kinase C{theta} in the Immunological Synapse. J Immunol. 2005;175:7829-7836. Cited in Pubmed; PMID 16339518.

Campi, G., R. Varma, and M.L. Dustin. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med. 2005;202:1031-1036. Cited in Pubmed; PMID 16216891.

Shakhar G, Lindquist RL, Skokos D, Dudziak D, Huang JH, Nussenzweig MC, Dustin ML. Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol. 2005;6:707-714. Cited in Pubmed; PMID 15924144.

Selected Books

Dustin ML, Starr T, Varma R, Thomas VK. Supported planar bilayers for study of the immunological synapse. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current Protocols in Immunology. Unit 18.13. New York: John Wiley and Sons; 2007.

Lebdeva T, Dustin ML, Sykulev Y. Target cell contributions to cytotoxic T cell sensitivity. In: Kropshofer H, Vogt AB, editors. Antigen Presenting Cells. Weinheim: Wiley-VCH; 2005. pp. 199-215.

Dustin ML. Beta2 integrins and their ligands in inflammation. In: Ley K, editor. Physiology of Inflammation. New York: Oxford University Press; 2001. pp. 242-62.

Dustin ML, Springer TA. Intercellular Adhesion Molecules (ICAMs) and LFA-1. In. In: Kreis T, Vale R, editors. Guidebook to the Extracellular Matrix, Anchor and Adhesion Proteins. Oxford: Oxford University Press; 1999. pp. 154-7, 216-20, 228-32.

Organizational Associations

American Society of Cell Biology; American Association of Immunologists

Selected Awards

1983  Phi Beta Kappa
1984  Sheilds Warren Award, Boston University
1986  Ryan Fellowship, Harvard University
1997  Englicheff Award, Arthritis Foundation
2000  Presidential Early Career Award in Science and Engineering
2000  Highly Cited Researcher in Immunology. Institute for Scientific Information.
2001  Keynote Speaker, FASEB Autoimmunity Conference.
2001  Irene Diamond Professorship in Immunology
2004  Special presentation, Workshop on CD1d and NKT cells, Heron Island Australia.
2005  Keynote Speaker, University of Texas Immunology Retreat.
2006  Keynote Speaker, "Imaging the immune synapse" Paris, France.
2006  Keynote Speaker, "Zoo meeting on cellular interactions" Amsterdam.
2006  Keynote Speaker, Harvard Medical School Immunology Program Retreat.
2007  Keynote Speaker, Biology in Motion, Cell Press and MGH, Evian, France.

Additional Information

Dustin Lab

© 2008 NYU Department of Pathology