• 
• 
• 
• 
• 
• 

Research and Clinical Interests

Dr. Demaria's main interest is cancer immunotherapy and the development of combination treatments with local ionizing radiation. Radiation has adjuvant effects that can be exploited to enhance anti-tumor immune responses. Her lab is currently investigating at the cellular and molecular levels the mechanisms mediating the effects of radiation on the tumor microenvironment and how they change the relationship between tumor and host immune system. Her clinical interest is breast cancer.

Selected Publications

Demaria S, Formenti SC. Sensors of ionizing radiation effects on the immunological microenvironment of cancer. Int J Radiat Biol. 2007 Aug 28;1-7. Cited in Pubmed; PMID 17852561.

Newcomb EW, Demaria S, Lukyanov Y, Shao Y, Schnee T, Kawashima N, Lan L, Dewyngaert JK, Zagzag D, McBride WH, Formenti SC. The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas. Clin Cancer Res. 2006 Aug 1;12(15):4730–7. Cited in Pubmed; PMID 16899624.

Demaria S, Bhardwaj N, McBride WH, Formenti SC. Combining radiotherapy and immunotherapy: a revived partnership. Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):655-66. Cited in Pubmed; PMID 16199306.

Demaria S, Santori FR, Ng B, Liebes L, Formenti SC, Vukmanovic S. Select forms of tumor cell apoptosis induce dendritic cell maturation. J Leukoc Biol. 2005 Mar;77(3):361–8. Cited in Pubmed; PMID 15569694.

Zagzag D, Salnikow K, Chiriboga L, Yee H, Lan L, Ali MA, Garcia R, Demaria S, Newcomb EW. Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain. Lab Invest. 2005 Mar;85(3):328-41. Cited in Pubmed; PMID 15716863.

Demaria S, Kawashima N, Yang AM, Devitt ML, Babb JS, Allison JP, Formenti SC. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):728-34. Cited in Pubmed; PMID 15701862.

Dong Y, Demaria S, Sun X, Santori FR, Jesdale BM, De Groot AS, Rom WN, Bushkin Y. HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase. Infect Immun. 2004 Apr;72(4):2414-5. Cited in Pubmed; PMID 15039371.

Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, Formenti SC. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):862-70. Cited in Pubmed; PMID 14967443.

Demaria S, Volm MD, Shapiro RL, Yee HT, Oratz R, Formenti SC, Muggia F, Symmans WF. Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy. Clin Cancer Res. 2001 Oct;7(10):3025-30. Cited in Pubmed; PMID 11595690.

Vukmanovic S, Lilic M, Santori FR, Demaria S, Kulig K. Peptide loading of nascent MHC class I molecules. Arch Immunol Ther Exp (Warsz). 2001;49(3):195-201. Cited in Pubmed; PMID 11478393.

Symmans WF, Volm MD, Shapiro RL, Perkins AB, Kim AY, Demaria S, Yee HT, McMullen H, Oratz R, Klein P, Formenti SC, Muggia F. Paclitaxel-induced apoptosis and mitotic arrest assessed by serial fine-needle aspiration: implications for early prediction of breast cancer response to neoadjuvant treatment. Clin Cancer Res. 2000 Dec;6(12):4610-17. Cited in Pubmed; PMID 11156210.

Demaria S, Bushkin Y. Soluble HLA proteins with bound peptides are released from the cell surface by the membrane metalloproteinase. Hum Immunol. 2000 Dec;61(120:1332-8. Cited in Pubmed; PMID 11163090.

Demaria S, DeVito-Haynes LD, Salter RD, Burlingham WJ, Bushkin Y. Peptide-conformed beta2m-free class I heavy chains are intermediates in generation of soluble HLA by the membrane-bound metalloproteinase. Hum Immunol. 1999 Dec;60(12):1216-26. Cited in Pubmed; PMID 10626735.

Demaria S, Bushkin Y. Soluble CD4 induces the binding of human immunodeficiency virus type 1 to cells via the V3 loop of glycoprotein 120 and specific sites in glycoprotein 41. AIDS Res Hum Retroviruses. 1996 Mar 1;12(4):281-90. Cited in Pubmed; PMID 8906988.

Demaria S, Schwab R, Gottesman SR, Bushkin Y. Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease. J Biol Chem. 1994 Mar 4;269(9):6689–94. Cited in Pubmed; PMID 8120026.

Selected Books

Bushkin Y, Watanabe H, Demaria S. Extracellular processing of MHC class I antigens. In: Wilkes DS, Burlingham WJ, editors. Immunobiology of Organ Transplantation. New York: Kluwer Academic/Plenum Publishers; 2004. pp. 53–65.

Organizational Associations

American Association for Cancer Research; Radiation Research Society

Selected Awards

1989-1992 The Damon Runyon-Walter Winchell Cancer Research Fund Award (DRG1050).
1993-1995 United States Public Health Service AIDS Training Grant.
2000-2001 Clinical Oncology Faculty Award (K12)
2001-2006 Clinical Investigator Award (NIH/NCI K08 CA89336)
2002-2005 The New York City Council Speaker's Fund for Biomedical Research: Toward the Science of Patient Care Award.
2003-2005 Breast Cancer Research Award from The Chemotherapy Foundation made possible by The Joyce and Irving Goldman Family Foundation.
2005 Travel scholarship to 2005 ASCI/AAP Joint Meeting.

Hospital Affiliations

Tisch Hospital

© 2008 NYU Department of Pathology