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Research and Clinical Interests

My research is focused on the clinical and laboratory biology of childhood acute lymphoblastic leukemia. The cure rate for this disease has improved dramatically, but one in five children will suffer a reoccurrence and their prognosis is dismal. We have developed an integrated genomic profile of blasts at diagnosis and relapse to discover mechanisms of drug resistance. These findings have been validated in pre-clinical models and agents that target these pathways are in clinical trials.

Organizational Associations

American Society of Hematology; American Society for Clinical Oncology; Society for Pediatric Research; American Association for Cancer Research; American Academy of Pediatrics; American Society for Clinical Investigation; American Society of Pediatric Hematology-Oncology

Selected Awards

1972    Vista Holt Scholarship
1972    Phi Kappa Phi
1977    UCI Alumni Award
1978    Alpha Omega Alpha
1978    UCI-CCM Humanitarian Award
1978    Evangeline Percival Award for Excellence in Pediatrics
1981    Medical Student Teaching Award (Resident Recipient)
1982    Resident Teaching Award (Faculty Recipient)
1983    NIH National Research Service Award
1985    NIH Clinical Investigator Award
1987    CURE Fellowship    
1988    Young Investigator Award (American Society for Clinical Oncology)
1989    NIH First Award
1990    Basil O'Connor Starter Scholar Research Award
2000    Governor's Award for Science and Technology
2002-2008 New York Magazine's Best Doctors, Pediatric Hematology-Oncology
2004-2008 America's Top Doctors, Pediatric Hematology/Oncology
2007    Hall of Honor, Cincinnati Children's Hospital Medical Center
2008    America's Top Doctors for Cancer
2009/10 Best Doctors in America