Silvia Buonamici, Ph.D.
Research Assistant Professor
Notch1, chemokines, T-cell leukemia developm./progression, CNS infiltration
buonas01@nyumc.org, (212) 263 5379
Fax: (212) 263 8211
550 First Avenue, MSB 538, New York, NY 10016
Research and Clinical Interests
Dr. Buonamici is interested in the pathogenesis of Notch1 induced T-cell leukemia (T-ALL), and its infiltration into the central nervous system (CNS), a process with devastating consequences to patients. She has found that activated Notch1 (a key regulator of T-cell development) induces chemokines which may be important in the migration of lymphoblasts into the CNS. She is working to define the role of these chemokines for future therapeutic use.
Selected Publications
Thompson BJ, Jankovic V, Gao J, Buonamici S, Vest A, Lee JM, Zavadil J, Nimer SD, Aifantis, I. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med. 2008 May;Epub 2008 May 12. Cited in Pubmed; PMID 18474632.
Buonamici S, Raetz E, Aifantis I. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol. 2008 Apr;Epub 2008 Apr 18. Cited in Pubmed; PMID 18421304.
Thompson B*, Buonamici S*, Palomero T, Vilimas T, Ferrando A, Aifantis I. The SCFFBW7 Ubiquitin Ligase Complex as a Tumor Suppressor in T-Cell Leukemia. JEM. 2007;204:1825–35. Cited in Pubmed; PMID 17646408.
Aifantis I, Vilimas T, Buonamici S. Notches, NFkappaBs and the making of T cell leukemia. Cell Cycle. 2007;6:403–6. Cited in Pubmed; PMID 17329966.
Vilimas T*, Mascarenhas J*, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I. Targeting the NF-κB signaling pathway in Notch1-induced T cell leukemia. Nature Medicine. 2007;13:70–7. Cited in Pubmed; PMID 17173050.
Buonamici S, Li D, Mikhail FM, Sassano A, Platanias LC, Colamonici O, Anastasi J, Nucifora G. EVI1 abrogates IFN-alpha response by selectively blocking PML induction. J Biol Chem. 2005;280:426–36. Cited in Pubmed; PMID 15519999.
Raza A, Buonamici S, Lisak L, Tahir S, Li D, Imran M, Chaudary NI, Pervaiz H, Gallegos JA, Alvi MI, Mumtaz M, Gezer S, Venugopal P, Reddy P, Galili N, Candoni A, Singer J, Nucifora G. Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression. Leuk Res. 2004;28:791–803. Cited in Pubmed; PMID 15203277.
Buonamici S, Ottaviani E, Visani G, Bonifazi F, Baccarani M and Martinelli G. AML1-ETO transcript expression patterns in acute mieloid leukemia patients with t(8;21) in complete haematological remission. Haematologica. 2004;89:103-5. Cited in Pubmed; PMID 14754613.
Martinelli G, Rondoni M, Buonamici S, Ottaviani E, Piccaluga PP, Malagola M, Baccarani M. Molecular monitoring to identify a threshold of CBFb/MYH11 transcript below which continuous complete remission of acute myeloid. Haematologica. 2004;89:495–7. Cited in Pubmed; PMID 15075086.
Buonamici S*, Li D*, Chi Y, Zhao R, Wang X, Brace L, Ni H, Saunthararajah Y, Nucifora G. EVI1 induces myelodysplastic syndrome in mice. J Clin Invest. 2004;114:713–9. Cited in Pubmed; PMID 15343390.
Candoni A, Silvestri F, Buonamici S, Li D, Reddy P, Galili N, Nucifora G, Raza A. Targeted therapies in myelodysplastic syndromes. Semin Hematol. 2004;41(2 Suppl 4):13–20. Cited in Pubmed; PMID 15190511.
Ibanez V, Sharma A, Buonamici S, Verma A, Kalakonda S, Wang J, Kadkol S, Saunthararajah Y. AML1-ETO Decreases ETO-2 (MTG16) Interactions with Nuclear Receptor Corepressor, an Effect That Impairs Granulocyte Differentiation. Cancer Res. 2004;64:4547–54. Cited in Pubmed; PMID 15231665.
Vitalyi S, Sinha KK, Chakraborty S, Buonamici S and Nucifora G. P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein. Biochem Biophys Res Commun. 2003;307:980–6. Cited in Pubmed; PMID 12878208.
Buonamici S, Chakraborty S, Vitalyi S and Nucifora G. The role of EVI1in normal and leukemic cells. Blood Cells Mol Dis. 2003;31:206–12. Cited in Pubmed; PMID 12972028.
Martinelli G, Ottaviani E, Buonamici S, Isidori A, Borsaru G, Visani G, Piccaluga PP, Malagola M, Testoni N, Rondoni M, Nucifora N, Tura S and Baccarani M. Association of 3q26 syndrome with different RPN1/EVI1 Fusion Transcripts. Haematologica. 2003;88:1221-8. Cited in Pubmed; PMID 14607750.
Organizational Associations
American Society of Hematology
