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Research and Clinical Interests

Current research interests focus on assessment of quality in undergraduate and graduate medical education, and assessment of patient safety and quality improvement programs in laboratory medicine, and development and implementation of cost effective clinical algorithms.

Selected Publications

Ocampo-Hafalla MT, Altamirano A, Basu AK, Chan MK, Ocampo JE, Cummings A Jr, Boorstein RJ, Cunningham RP, Teebor GW. Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization. DNA repair (Amst.). 2006;5:444–50. Cited in Pubmed; PMID 16446124.

Marenstein DR, Chan MK, Altamirano A, Basu AK, Boorstein RJ, Cunningham RP, Teebor GW. Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. Journal of Biological Chemistry. 2003 Mar 14;278(11):9005–12. Cited in Pubmed; PMID 12519758.

Ulbert S, Cross M, Boorstein RJ, Teebor GW, Borst P. Expression of the human hSMUG1 in Trypanosoma Brucei causes DNA damage and interferes with J. Biosynthesis. Nucleic Acids Res. 2002 Sep 15;30(18):3919–26. Cited in Pubmed; PMID 12235375.

Boorstein RJ, Cummings A, Marenstein DR, Chan, MK, Ma, Y, Neubert, TA. Definitive Identification of Mammalian 5-Hydroxymethyluracil DNA N-glycosylase as SMUG1. Journal of Biological Chemistry. 2001;276:41991-7.

Mi LJ, Chaung W, Horowitz R, Teebor GW, Boorstein RJ. Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese Hamster V79 cells containing mutan. Carcinogenesis. 2001;22:179–86.

Mi LJ, Brandon M, Chaung W, Teebor GW, Boorstein RJ. 5-Chloro-2’-deoxyuridine cytoxicity results from base excision repair of uracil subsequent to thymidylate inhibition. Mutation Research. 2000;459:161-169.

Chaung W, Mi LJ, Boorstein RJ. The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair. Nucleic Acids Research. 1997;25:992-4.

Chaung W, Boorstein RJ. Molecular spectrum of mutations induced by 5-hydroxymethyl-2’deoxyuridine in (CH0)-PL61 cells. Mutation Research. 1997;373:125-37.

Mi LJ, Mahl E, Chaung W, Boorstein RJ. Lack of phenotypic alteration of hmUra-DNA glycosylase deficient cells exposed to DNA damaging agents. Mutation Research. 1997;374:287-95.

Boorstein RJ, Haldar J, Poirier G, Putnam D. DNA base excision repair of 5-hydroxymethyl-2'-deoxyuridine stimulates poly(ADP-ribose) synthesis in Chinese Hamster cells. Carcinogenesis. 1995;16:1172-79.

Boorstein RJ, Chiu LN, Teebor GW. A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine. Molecular and Cellular Biology. 1992;12:5536-40.

Boorstein RJ, Teebor GW. Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells. Cancer Research. 1989;49:1509-14.

Boorstein RJ, Chiu LN, Teebor GW. Phylogenetic evidence of a role for 5-hydroxymethyluracil-DNA glycosylase in the maintenance of 5-methylcytosine in DNA. Nucleic Acids Research. 1989;17:7653-61.

Boorstein RJ, Levy DD, Teebor GW. 5-Hydroxymethyluracil-DNA glycosylase activity may be a differentiated mammalian function. Mutation Research. 1987;183:257-63.

Boorstein RJ, Pardee AB. Modification of 3-Aminobenzamide cytotoxicity in normal and repair deficient human fibroblasts. Journal of Cellular Physiology. 1984;120:335-44.

Selected Awards

2000 Alpha Omega Alpha, Faculty Inductee
1993-1997 Hirschl Trust Career Scientist Program
1991-1992 Whitehead Presidential Fellowship
1990-1995 NIH FIRST Award
1990-1993 American Cancer Society Junior Faculty Research Award
1990-1992 Kaplan Scholar Award Program
1989-1990 Henry Hirsch Fellowship in Oncology
1986-1989 American Cancer Society Post-doctoral Fellowship
1985-1986 NIH Pathobiology Training Grant Fellowship
1978-1983 MSTP Fellowship,MD-PhD Program, Harvard Medical School
1977 Detur Book Prize, Harvard University
1976 Phi Beta Kappa
1975 John Harvard Scholarship

Hospital Affiliations

Bellevue Hospital