Research and Clinical Interests
We have identified the TBL1/TBLR1 family of regulatory proteins that interact with transcriptional repressors. They regulate the stability of their targets by controlling their susceptibility to ubiquitin mediated proteasomal degradation. The regulation of transcriptional activity plays a pivotal role in lineage specification and TBLR1 appears to play a critical role in this process. Recently we have shown that it also plays a role in tumor progression.
Zhang XM, Chang Q, Gu J, Zeng L, Brown S, Basch RS. TBLR1 regulates the expression of nuclear hormone receptor co-repressors. BMC Cell Biol. 2006 Aug 7;7:31. Cited in Pubmed; PMID 16893456.
Gupta R, Karpatkin S, Basch RS. Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase. Blood. 2006 Mar 1;107(5):1837–46. Epub 2005 Nov 8. Cited in Pubmed; PMID 16278309.
Shaw JP, Basch RS, Shamamian P. Characterization of bone marrow stem cells contributing to tumor angiogenesis. Blood Cell Mol Dis. 2004;32:168–75.
Shankar SL, O'Guin K, Cammer M, McMorris FA, Stitt TN, Basch RS, Varnum B, Shafit-Zagardo B. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J Neurosci. 2003 May 15;23(10):4208–18. Cited in Pubmed; PMID 12764109.
Dormady SP, Bashayan O, Dougherty R, Zhang XM, Basch RS. Immortalized mesenchymal stem cells and the hematopoietic microenvironment. J Hematother Stem Cell Res. 2001 Feb;10(1):125–40. Cited in Pubmed; PMID 11276366.
Li JJ, Huang YQ, Basch R, Karpatkin S. Thrombin induces the release of angiopoietin-1 from platelets. Thromb Haemost. 2001 Feb;85(2):204–6. Cited in Pubmed; PMID 11246533.
Zhang XM, Dormady SP, Chaung W, Basch RS. mVH1, A dual-specificity phosphatase, whose expression is cell-cycle regulated. Mamm Genome. 2000 Dec;11(12):1154–6. Cited in Pubmed; PMID 11130991.
Zhang XM, Dormady SP, Basch RS. Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors. Exp Hematol. 2000 Nov;28(11):1286–96. Cited in Pubmed; PMID 11063877.
Dormady SP, Zhang XM, Basch RS. Multipotential hematopoietic cell progenitors grow on 3T3 fibroblast monolayers that over-express GAS6. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12260–5. Cited in Pubmed; PMID 11050245.
Miller D, Ortega S, Bashayan O, Basch RS, Basilico C. Compensation by fibroblast Growth Factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol Cell Biol. 2000 Mar;20(6):2260–8.
International Society for Analytic Cytometry; American Association of Immunologists; New York Academy of Sciences