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Michele Pagano, M.D.
Ubiquitin system, cell division cycle checkpoints, cancer
The mammalian SCF (Skp1/Cul1/F-box protein) ubiquitin ligases are critical for the attenuation/activation of many cellular functions. They control molecular machines by directing the proteolysis of important regulatory elements in a precise, rapid, and localized manner. We found that SCF regulates multiple and seemingly disparate cellular pathways: protein synthesis, ribosomal biogenesis, cell survival, DNA-damage checkpoints, the circadian clock, etc. We also study how this regulatory network is deregulated in cancer cells.
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