|
96. J. Skaar, D. Richard, A. Toschi, A. Saraf, E. Bolderson, L. Florens, M. Washburn, K. Khanna, and M. Pagano
INTS3 controls the hSSB1-mediated DNA damage response
J of Cell Biol, 187:25-32, 2009.
95. E. Dehan, F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K. Lowes, M. Dustin, D. Huang, J. Taunton, and M. Pagano
βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
Mol Cell, 33:109-111, 2009.
94. S. Ge, J. Skaar, and M. Pagano
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation
Cell Cycle, 8:167-171, 2009.
93.L. Hu, S. Ibrahim, C. Liu, J. Skarr, M. Pagano, and S. Karpatkin
Thrombin induces tumor cell cycle activation and spontaneous growth by downregulation of p27Kip1, in association with the upregulation of Skp2 and mir-222
Cancer Research, 69:3374-3381, 2009.
92. F. Bassermann, D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, and M. Pagano.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint.
Cell 134, 256-267, 2008.
91. D. Frescas, D. Guardavaccaro, S.Kuchay, H. Kato,A. Poleshko, V. Basrur, K. Elenitoba-Johnson, R. Katz, and M. Pagano.
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.
Cell Cycle 7, 3539-3547, 2008.
90. T. Abbas, U. Sivaprasad, K. Terai, V. Amador, M. Pagano, and A Dutta.
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Genes & Development 22:2496-2506, 2008.
89. D. Guardavaccaro, D. Frescas, N. Dorrello, A. Peschiaroli, A. Multani, T. Cardozo, A. Lasorela, A. Iavarone, S. Chang, E. Hernando, and M. Pagano.
Control of chromosome stability by the βTRCP-REST-MAD2 axis.
Nature 452:365-369, 2008.
88. X. Zhao, J. Heng, D. Guardavaccaro, M. Pagano, F. Guillemot, A. Iavarone and A. Lasorela.
The HECT-domain ubiquitin ligase Ureb1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Nature Cell Biol 10:643-653, 2008.
87. D. Michaelson, W. Abidi, D. Guardavaccaro, M. Zhou, I. Ahearn, M. Pagano and M. Philips.
Rac1 Accumulates in the Nucleus During the G2 Phase of the Cell Cycle and Promotes Cell Division.
J of Cell Biology 181:485-496, 2008.
86. D. Frescas, D.
Guardavaccaro, F. Bassermann, R. Koyama-Nasu and
M. Pagano.
The histone demethylase JHDM1B/FBXL10 is a
nucleolar protein that represses transcription of ribosomal
RNA genes.
Nature 450:309-313, 2007.
85. L. Busino, F. Bassermann,
A. Maiolica, C Lee, S. Godinho, P. Nolan, G. Draetta and M.
Pagano.
SCF-Fbxl3 Controls the Oscillation of the Circadian Clock by
Directing the Degradation of Cryptochrome Proteins.
Science 316:900-904, 2007.
84.
V. Amador, S. Ge, P.G. Santamaria, D. Guardavaccaro and M.
Pagano.
APC/CCdc20 controls the ubiquitin-mediated
degradation of p21 in prometaphase.
Mol Cell
27:462-473, 2007.
83. S. Godinho, E. Maywood, L. Shaw, V. Tucci, A. Barnard,
L. Busino, M. Pagano, R. Kendall, M. Quwailid, R. Romero, J.
O'Neill, J. Chesham, D. Brooker, Z. Lalanne, S. Hastings and
P. Nolan.
The after hours mutant reveals a role for FBXL3 in
determining mammalian circadian period.
Science 316:897-900, 2007.
82. S. Kitajima, Y. Kudo, I. Ogawa, M. Tatsuka, H. Kawai, M. Pagano, T. Takata.
Constitutive phosphorylation of Aurora-A on Ser51 induces its stabilization
and consequent overexpression in cancer.
Plos One 2:e944-doi:10.1371, 2007.
81. Y. Peng,C. Li, F. Chen, Z.Wang, M. Ligr, J. Melamed, J. Wei, W. Gerald, M.
Pagano, M. Garabdian and P. Lee.
Stimulation of prostate cancer cell proliferation and invasion by the
Androgen receptor co-activator ARA70.
Am J of Path 172:225-235, 2007.
80. N. Fielenbach, D. Guardavaccaro, K. Neubert, T. Chan, D.
Li, Q. Feng, H. Hutter, M. Pagano and A. Antebi.
DRE-1, an evolutionarily conserved F-box protein that
regulates C. elegans developmental age.
Dev Cell 12:443-445, 2007.
79. F. Bassermann, C. vonKlitzing, A. Illert, S. Munch, S.
Morris, M. Pagano, C. Peschel and J. Duyster.
Multisite phosphorylation of Nipa at G2/M involves cyclin
B1/Cdk1.
J of Biological Chemistry 282:15965-15972, 2007.
78. S. Xu, M. Abbasian, P. Patel, K. Jensen, C. Lombardo, B.
Cathers, W. Xie, F. Mercurio, M. Pagano, D. Giegel and S.
Cox.
Substrate recognition and ubiquitination of SCFSkp2/Cks1 E3
ligase.
J of Biological Chemistry 282:15462-15470, 2007.
77. N. V. Dorrello, A. Peschiaroli, D.
Guardavaccaro*, N. H. Colburn, N. E. Sherman and M.
Pagano.
S6K1- and βTRCP-mediated degradation of PDCD4 promotes
protein translation and cell growth.
Science 314:467-471, 2006.
76. A. Peschiaroli,
N. V. Dorrello, D. Guardavaccaro, M. Venere, T.
Halazonetis, N. Sherman and M. Pagano.
SCFβTRCP-mediated degradation of Claspin regulates
recovery from the DNA replication checkpoint response.
Mol Cell 23:319-329, 2006.
75. Y. Utku, E. Dehan, O. Ouerfelli, F. Piano,
R. N. Zuckermann, M. Pagano and K. Kirshenbaum.
A peptidomimetic siRNA transfection reagent for
highly effective gene silencing.
Mol Biosystems 2:312-317, 2006.
74. P. Ji, L. Goldin, H. Ren, D. Sun, D Guardavaccaro,
M. Pagano and L. Zhu.
Skp2 contains a novel cyclin a binding domain that
directly protects cyclin A from inhibition by p27.
J of Biological Chemistry
281:24058-24069, 2006.
73. J. Bloom, A. Peschiaroli, G. DeMartino
and M. Pagano.
Modification of Cul1 regulates its association with
proteasomal subunits.
Cell Div 1:5, 2006.
72. A. Lasorella, J. Stegmueller, G. Rothschild,
D. Guardavaccaro, L. delaTorre, M. Pagano, A Bonni
and A. Iavarone.
Degradation of Id2 by the anaphase-promoting
complex couples cell cycle exit and axonal growth.
Nature
442:471-474, 2006.
71. K. Block, S. Appikonda, A. Horng-Ru Lin,
J. Bloom, M. Pagano, and R. Yew.
The acidic tail domain of human Cdc34 is required
for p27Kip1 ubiquitination and complementation of
a cdc34 temperature sensitive yeast strain.
Cell Cycle 4:1421-1427,
2005.
70. B. Hao, N. Zheng, B. Schulman, G. Wu,
J. Miller, M. Pagano, and N. Pavletich.
Structural basis of the Cks1-dependent recognition
of p27Kip1 by the SCFSkp2 ubiquitin ligase.
Mol Cell 20:9-19,
2005.
69. R. Benmamar and M. Pagano.
Involvement of the SCF Complex in the Control of
Cdh1 Degradation in S-phase.
Cell Cycle 4:1230-1232,
2005.
68. P. Ji, H. Jiang, K. Rekhtman, J. Bloom,
M. Ichetovkin, M. Pagano and L Zhu.
An Rb-Skp2-p27 pathway mediates acute cell cycle
inhibition by Rb and is retained in a partial-penetrance
Rb mutant.
Mol Cell 16:47-56, 2004.
67. S. Kitajima, Y Kudo, I. Ogawa, T. Bashir,
M. Kitagawa, M. Miyauchi, M. Pagano and T. Takata.
Role of Cks1 overexpression in oral squamous cell
carcinomas: cooperation with Skp2 in promoting p27
degradation.
Am J Pathol 165: 2147-2155, 2004.
67. Y. Kudo, D. Guardavaccaro, P. Santamaria,
R. Nasu, E. Latres, R. Bronson, L. Yamasaki and M. Pagano.
Role of F-box protein βTrcp1 in mammary gland development
and tumorigenesis.
Mol Cell Biol 24:8184-8194,
2004.
66. F. Bernassola, P. Salomoni, A. Oberst,
C. Di Como, M. Pagano, G. Melino and P. Padolfi.
Ubiquitin-dependent degradation of p73 is Inhibited
by PML.
J Exp Med 99:1545-1557, 2004.
65. Y. Moshe, J. Boulaire, M. Pagano and
H. Hershko.
Role of Polo-like kinase in the degradation of Emi1,
a regulator of the Anaphase Promoting Complex/Cyclosome.
Proc Natl Acad Sci USA
101:7937-7942, 2004.
64. M. Shapira, O. Ben-Izhak, B. Bishara,
B. Futerman, I. Minkov, M. Krausz, M. Pagano, and
D. Hershko.
Alterations in the expression of the cell cycle
regulatory protein Cks1 in colorectal carcinoma.
Cancer, 100:1615-21, 2004.
63. T. Bashir, V. Dorrello, V. Amador, D.
Guardavaccaro and M. Pagano.
Control of the SCFSkp2-Cks1 ubiquitin ligase by
the APC/CCdh1 ubiquitin ligase.
Nature 248:190-193, 2004.
62. J. Bloom, V. Amador, F. Bartolini, G.
DeMartino and M. Pagano.
Proteasome-mediated degradation of p21 via N-terminal
ubiquitinylation.
Cell 115:71-82, 2003.
61. L. Busino, M. Donzelli, M. M. Chiesa,
D. Guardavaccaro, D. Ganoth, N. V. Dorrello, A.
Hershko, M. Pagano and G. Draetta.
Ubiquitin-mediated degradation of Cdc25A by βTrcp
during S phase and in response to DNA damage.
Nature 426: 87-91, 2003.
60. G. Bornstein, J. Bloom, D. Sitri, K.I.
Nakayama, M. Pagano, and A. Hershko.
Role of the SCFSkp2 ligase in the degradation of
p21Cip1 In S phase.
J of Biological Chemistry
278: 25752-25757, 2003.
59. D. Guardavaccaro, Y. Kudo, J. Boulaire,
M. Barchi, L. Busino, M. Donzelli, F. Margottin,
P. Jackson, Yamasaki L. and M. Pagano.
Control of meiotic and mitotic progression by the
F-box protein βTrcp1 in vivo.
Dev. Cell 4: 799-812,
2003.
58. M. Drobnjak, J. Melamed, T. Taneja, K.
Melzer, R. Wieczorek, B. Levinson, A. Zeleniuch,
D. Polsky, J. Ferrara, R. Perez-Soler, C. Cordon-Cardo,
M. Pagano and I. Osman.
Altered
expression of p27 and Skp2 proteins in prostate
cancer of african-american patients.
Clin. Cancer Research 9:2613-2619, 2003.
57. S. McAllister, M. Becker-Hapak, G. Pintucci,
M. Pagano and S. F. Dowdy.
Novel p27 C-terminal scatter domain mediates Rac-dependent
cell migration independent of cell cycle arrest
functions.
Mol Cell Biol 23:216-228, 2003.
56. D. Sitri, M. A. Seeliger, T. K. Ko, D.
Ganoth, L. S. Itzhaki, M. Pagano and A. Hershko.
Three different binding sites of Cks1 are required
for p27-ubiquitin ligation.
J of Biological Chemistry
277:42233-42240, 2002.
55. M. Donzelli, M. Squatrito, D. Ganoth,
Hershko, A., M. Pagano and G. F. Draetta.
Dual Mode of Degradation of Cdc25 A phosphatase.
EMBO J 21:4875-4884,
2002.
54. R. Piva, J. Liu, R. Chiarle, A. Podda,
M. Pagano, and G. Inghirani.
In vivo interference with Skp1 function leads to
genetic instability and neoplastic transformation.
Mol Cell Biol 22:8375-8387, 2002.
53. S. Signoretti, L. Dimarcotullio, A. Richardson,
S. Ramaswamy, B. Isaac, M. Rue, F. Monti, M. Loda
and M. Pagano.
Oncogenic role of the ubiquitin ligase subunit Skp2
in human breast cancer.
J of Clinical Investigation
110:633-641, 2002.
52. N. Zheng, B. Schulman, J. Miller, P.
Wang, P. Jeffrey, C. Chu, D. M. Koepp, S. Elledge,
M. Pagano, R. Conaway, J. Conaway, J. Harper and
N. Pavletich.
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin
Ligase Complex.
Nature 416:703-709, 2002.
51. R. Chiarle, F. Yan, R. Piva, H. Boggino,
J, Skolnik, D. Novero, G. Palestro, C. DeWolf, M.
Chilosi, M. Pagano, and G. Inghirani.
Skp2 expression in non-Hodgking lymphomas inversely
correlates with p27 expression and defines cells
in S-phase.
Am J Pathol 160: 1457-1466, 2002.
50. H. Cheng, C. Cenciarelli, Z. Shao, M.
Vidal, W. Parks, M. Pagano and C. Cheng-Mayer.
Human T cell leukemia virus type 1 Tax associates
with a molecular chaperone complex containing hTid-1
and Hsp70.
Current Biology 11: 1771-1775, 2001.
49. G. Rodier, A. Montagnoli, L. DiMarcotullio,
P. Coulombe, G. Draetta, M. Pagano and S. Meloche.
p27 cytoplasmic localization is regulated by phosphorylation
on serine 10 and is not a prerequisite for its proteolysis.
EMBO J 20: 6672-6682,
2001.
48. V. S. Spiegelman, P. Stavropoulos, E.
Latres, M. Pagano, H. Furneaux, T. J. Slaga, and
S. Y. Fuchs.
Induction
of b-TrCP/Fbw1a by JNK signaling and its role in
the activation of NF-kB.
J of Biological Chemistry 29: 27152-27158, 2001.
47. A. C. Carrano and M. Pagano.
Role of the F-box protein Skp2 in adhesion-dependent
cell cycle progression.
J of Cell Biology 153:
1381-1389, 2001.
46. L. Desalle, E. Latres, D. Lin, E. Graner,
A. Montagnoli, R. Baker, M. Pagano and M. Loda.
The De-ubiquitinating enzyme Unp interacts with
the Retinoblastoma protein.
Oncogene 20:5538-42 2001.
45. D. Ganoth, G. Bornstein, T. K. Ko, B.
Larsen, M. Tyers, M. Pagano and A. Hershko.
The cell cycle regulatory protein Cks1 is required
for the SCFSkp2-mediated ubiquitinylation of p27.
Nature Cell Biol 3: 321-324,
2001.
44. E. Latres, R. Chiarle, B. Schulman, N.
Pavletich, A. Pellicer, G. Inghirani and M. Pagano.
Role of the F-box protein Skp2 in lymphomagenesis.
Proc Natl Acad Sci USA
98: 2515-2520, 2001.
43. D. Hershko, G. Bornstein, O. Ben-Izhak,
A. Carrano, M. Pagano, M. Krausz, and A. Hershko.
Inverse relationship between levels of p27Kip1 and
of its ubiquitin ligase subunit Skp2 in colorectal
carcinomas.
Cancer 91: 1745-1751, 2001.
42. B. Schulman, A.C. Carrano, P. Jeffrey,
Z. Bowen, E. Kinnucan, M. Finnin, S. Elledge, W.
Harper, M. Pagano and N. Pavletich.
Insights into SCF ubiquitin ligases from the structure
of the Skp1-Skp2 complex.
Nature 408: 381-386,
2000.
41. M. Cangi, B. Cukor, P. Soung, S. Signoretti,
G. Moreira, M. Ranashinge, B. Cady, M. Pagano and
M. Loda.
Role of the Cdc25A phosphatase in human breast cancer.
J of Clinical Investigation 106: 753-761, 2000.
40. V. Spiegelman, T. Slaga, M. Pagano, T.
Minamoto, Z. Ronai and S. Y. Fuchs.
Wnt/b-catenin signaling induces the expression and
activity of b-TrCP ubiquitin ligase receptor.
Mol Cell 5: 877-882, 2000.
39. D. S. Chiaur, S. Murthy, C. Cenciarelli,
M. Loda, G. Inghirani, W. Parks, D. Demetrick, and
M. Pagano.
Five human genes encoding FBP: Chromosomal mapping
and analysis of gross mutations in human tumors.
Cytogenetics and Cell
Genetics 88: 255-258, 2000.
38. M. Chilosi, R. Chiarle, M. Lestani, F.
Menestrina, L. Montagna, A. Ambrosetti, G. Prolla,
G. Pizzolo, C. Doglioni, R. Piva, M. Pagano, and
G. Inghirani.
Low expression of p27 and low proliferation index
do not correlate in hairy cell leukemia.
British J of Haematology 111:263-271, 2000.
37. R. Chiarle, L. Budel, J. Skolnik, G.
Frizzera, M. Chilosi, A. Corato, G. Pizzolo, J.
Magidson, A. Montagnoli, M. Pagano, B. Maes, C.
DeWolf, and G. Inghirani.
Increased proteasome degradation of cyclin-dependent
kinase inhibitor p27 is associated with a decreased
overall survival in mantle cell lymphoma.
Blood 95: 619-626, 2000.
36. C. Cenciarelli, D. S. Chiaur, D. Guardavaccaro,
W. Parks, M. Vidal, and M. Pagano.
Identification of a family of human F-box proteins.
Current Biology 9: 1177-1179, 1999.
35. A. C. Carrano, E. Eytan, A. Hershko,
and M. Pagano.
Skp2 is required for the ubiquitin-mediated degradation
of the Cdk-inhibitor p27.
Nature Cell
Biol 1: 193-199, 1999.
34. A. Montagnoli, F. Fiore, E. Eytan, A.
C. Carrano, G. Draetta, A. Hershko, and M. Pagano.
Ubiquitination of p27 is regulated by Cdk-dependent
phosphorylation and trimeric complex formation.
Genes & Development
13: 1181-1189, 1999.
33. E. Latres, D. S. Chiaur, and M. Pagano.
The human F-box protein b-Trcp associates with the
Cul1/Skp1 complex and regulates the stability of
b-catenin.
Oncogene 18: 849-854, 1999.
32. H. Gonen, B. Bercovich, A. Orian, A.
C. Carrano, C. Takizawa, M. Pagano, K. Iwai, and
A. Ciechanover.
Identification of the ubiquitin carrier proteins,
E2s, involved in signal-induced conjugation and
subsequent degradation of IkBa.
J of Biological Chemistry 274: 14823-14830, 1999.
31. G. Thomas, K. Szigeti, M. Murphy, G.
Draetta, M. Pagano, and M. Loda.
Downregulation of p27 is associated with development
of colorectal adenocarcinoma metastases.
Am J Pathol 153: 681-687, 1998.
30. Z. Lu, D. Liu, A. Hornia, W. Devonish,
M. Pagano, and D. Foster.
Tumor promotion by phorbol ester-induced depletion
of protein kinase C is mediated by the ubiquitin-proteasome
pathway.
Mol Cell Biol 18: 839-845, 1998.
29. Y. Zhang, Z. Wang, D. Liu, M. Pagano,
and K. Ravid.
Ubiquitin-dependent degradation of Cyclin B1 is
accelerated in polyploid megacariocytes.
J of Biological Chemistry 273: 1378-1392, 1998.
28. S. Singh, J. Lipman, H. Goldman, F. H.
Ellis Jr., L. Aizenman, M. G. Cangi, S. Signoretti,
D. S. Chiaur, M. Pagano, and M. Loda.
Loss or altered subcellular localization of p27
in Barrett's associated adenocarcinoma.
Cancer Research 58: 1730-1735, 1998.
27. V. Esposito, A. Baldi, A. DeLuca, G.
Sgaramella, G. Giordano, M. Caputi, M. Pagano, and
G. Giordano.
Prognostic role of the cell cycle inhibitor p27
in non-small cell lung cancer.
Cancer Research 57: 3381-3385, 1997.
26. S. Millard, J. Yan, H. Nguyen, M. Pagano,
H. Kiyokawa, and A. Koff.
Enhanced ribosomal association of p27Kip1 mRNA,
a mechanism contributing to accumulation during
growth arrest.
J of Biological Chemistry 272: 7093-7098, 1997.
25. P. Tan, B. Cady, M. Wanner, B. Cukon,
C. Magi-Galluzzi, P. Lavin, G. Draetta, M. Pagano,
and M. Loda.
The cell cycle inhibitor p27 is an independent marker
in small (T1a,b) invasive breast carcinomas.
Cancer Research 57: 1259-1263, 1997.
24. M. Loda, B. Cukon, S. Tam, P. Lavin,
M. Fiorentino, G. Draetta, J. Jessup, and M. Pagano.
Increased proteasome-dependent degradation of the
CDK inhibitor p27 in aggressive colorectal carcinomas.
Nature Med 3: 231-234, 1997.
23. E. Grinstein, I. Weiert, B. Droese, M.
Pagano, and H. Royer.
Cell cycle regulation of nuclear factor p92 DNA
binding activity by novel phase-specific inhibitors.
J of Biological Chemistry 271: 9215-9222, 1996.
22. J. Chen, R. Peters, P. Saha, P. Lee,
A. Theodoras, M. Pagano, G. Wagner, and A. Dutta.
A 39 amino acid fragment of the cell cycle regulator
p21 is sufficient to bind PCNA and partially inhibit
DNA replication in vivo.
Nucl Acids Res 24: 1727-1733, 1996.
21. P. Steiner, A. Philip, J. Lukas, D. Godden,
M. Pagano, S. Mittnacht, J. Bartek, and M. Eilers.
Identification of a Myc-dependent step during the
assembly of active cyclin/cdk complexes.
EMBO J 14: 4814-4826, 1995.
20. M. Roussel, A. Theodoras, M. Pagano,
and C. Sherr.
Rescue of defective mitogenic signaling by D-type
cyclins.
Proc Natl Acad Sci USA 92: 6837-6841, 1995.
19. M. Ohtsubo, A. Theodoras, J. Schumacher,
J. Roberts, and M. Pagano.
Human Cyclin E, a nuclear protein essential for
the G1 to S phase transition.
Mol Cell Biol 15: 2612-2624, 1995.
18. M. Rolfe, P. Romero, S. Glass, I. Berdo,
A. Theodoras, M. Pagano, and G. Draetta.
Reconstitution of p53-ubiquitinylation from purified
components: the role of human Ubc4 and E6AP.
Proc Natl Acad Sci USA 92: 3264-3268, 1995.
17. M. Pagano, S. Tam, A. Theodoras, P. Beer,
S. Delsal, V. Chu, R. Yew, G. Draetta, and M. Rolfe.
Role of the Ubiquitin-Proteasome pathway in regulating
abundance of the CDK inhibitor p27.
Science 269: 682-685, 1995.
16. S. Tam, J. W. Shay, and M. Pagano.
Differential expression and cell cycle regulation
of the Cdk4 inhibitor p16Ink4.
Cancer Research 54: 5816-5820, 1994.
15. S. Tam, A. Theodoras, J. W. Shay, G.
Draetta, and M. Pagano.
Differential expression and regulation of Cyclin
D1 protein in normal and tumor human cells: association
with Cdk4 is required for Cyclin D1 function in
G1 progression.
Oncogene 9: 2663-2674, 1994.
14. M. Pagano, A. M. Theodoras, S. W. Tam,
and G. Draetta.
Cyclin D1-mediated inhibition of repair and replicative
DNA synthesis in human fibroblasts.
Genes & Development 8: 1627-1639, 1994
13. D. Spitkovsky, P. Steiner, J. Lukas,
E. Lees, M. Pagano, A. Schulze, S. Joswig, M. Tommasino,
M. Eilers, and P. Jansen-Dürr.
Modulation of cyclin gene expression by E1A in a
cell line with E1A-dependent conditional proliferation.
J of Virology 68: 2206-2214, 1994.
12. J. Lukas, M. Pagano, Z. Staskova, G.
Draetta, and J. Bartek.
Cyclin D1 protein oscillates and is essential for
cell cycle progression in human tumor cell lines.
Oncogene 9: 707-718, 1994.
11. A. Migliacio, M. Pagano, and F. Aurichio.
Immediate and transient stimulation of protein tyrosine
phosphorylation by estradiol in MCF-7 cells.
Oncogene 8: 2183-2191, 1993.
10. P. O'Connor, D. Ferris, M. Pagano, G.
Draetta, J. Pines, T. Hunter, D. Longo, K. Kohn.
G2 delay induced by nitrogen mustard in human cells
affects Cyclin A/Cdk2 and CyclinB/Cdc2 kinase complexes
differentially.
J of Biological Chemistry 268: 8298-8308, 1993.
9. V. Baldin, J. Lukas, M. J. Marcote, M.
Pagano, and G. Draetta.
Human Cyclin D1 is a nuclear protein required for
cell cycle progression in G1.
Genes & Development 7: 812-821, 1993.
8. P. J. Dürr, A. Meichle, P. Steiner, M.
Pagano, K. Finke, J. Botz, J. Wess, G. Draetta,
and M. Eilers.
Differential modulation of cyclin gene expression
by myc.
Proc atl Acad Sci USA 90: 3685-3689, 1993.
7. M. Pagano, R. Pepperkok, J. Lukas, V.
Baldin, W. Ansorge, J. Bartek, and G. Draetta.
Regulation of the cell cycle by the Cdk2 protein
kinase in cultured human fibroblasts.
J of Cell Biology 121: 101- 111, 1993.
6. M. Pagano, M. Dürst, S. Joswig, G. Draetta,
and P. Jansen-Dürr.
Binding of the human E2F transcription factor to
the retinoblastoma protein but not Cyclin A is abolished
in HPV 16-immortalized cells.
Oncogene 7: 1681-1686, 1992.
5. Y. Landesman, M. Pagano, G. Draetta, V.
Rotter, N. Fusenig, and A. Kimchi.
Modification of cell cycle controlling nuclear proteins
by TGF-ß in HaCaT Keratinocyte cell-line.
Oncogene 7: 1661-1665, 1992.
4. P. Clarke, D. Leiss, M. Pagano, and E. Karsenti.
Cyclin A and Cyclin B-dependent protein kinases
are regulated by different mechanisms in Xenopus
egg extract.
EMBO J 11: 1751-1761, 1992.
3. L. Thomas, P. R. Clarke, M. Pagano, and
J. Gruenberg.
Inhibition of membrane fusion in vitro via Cyclin
B but not Cyclin A.
J of Biological Chemistry 67: 6183-6187, 1992
2. M. Pagano, R. Pepperkok, F. Verde, W.
Ansorge, and G. Draetta.
Cyclin A is required at two points in the human
cell cycle.
EMBO J 11: 961-972, 1992.
1. M. Pagano, G. Draetta, and P. Jansen-Dürr.
Association of Cdk2 kinase with the transcription
factor E2F during S phase.
Science 255: 1144-1147, 1992.
Reviews, Chapters and
Commentaries
47. J. Skaar, D’Angiolella, V., Pagan, J., and M. Pagano.
SnapShot: F box proteins II.
Cell 137:1358-1358e1, 2009.
46. J. Skaar, Pagan, J. and M. Pagano.
SnapShot: F box proteins I.
Cell 137:1160-1160e.1, 2009.
43. D. Frescas and Pagano.
Deregulated proteolysis by the F-box proteins Skp2 and ß-TrCP: Tipping the scales of cancer.
Nature Reviews Cancer, 8:438-449, 2008.
42. T. Cardozo and M. Pagano.
Wrenches in the Works: Drug Discovery Targeting the SCF Ubiquitin Ligase and APC/C Complexes.
BMC Biochemistry, 8: doi:10.1186/1471-2091-8-S1-S9, 2007.
38. M. Pagano.
Amerian Idol and NIH grant review.
Cell, 126:637-638, 2006.
37.
P.
Kaldis and M. Pagano.
Cell Division, a
new open access online forum for and from the cell
cycle community.
Cell Div,
1:1 doi:10.1186/1747-1028-1-1 2006.
36. D. Guardavaccaro
and M. Pagano.
Stabilizers and destabilizers controlling cell cycle
oscillators.
Mol Cell, 22:1-4 2006.
35. T. Bashir and M. Pagano.
Cdk1, the dominant sibling of Cdk2.
Nature Cell Biol, 8:779-781,
2005.
34. E. Dehan and M. Pagano.
Skp2, the FoxO1 hunter.
Cancer Cell, 7:209-210, 2005.
33. T. Bashir, D.
Guardavaccaro, N. V. Dorrello, V. Amador, and M. Pagano.
Reciprocal control of the G1/S ubiquitin ligase SCF and
the mitotic ubiquitin ligase APC/C: A role for Skp2 and
ßTrcp in cancer.
AACR Education Book 1: 1315 – 1316, 2004.
32. J. Bloom and M. Pagano.
Tests to definitively determine ubiquitylation of
a substrate.
Meth in Enzymol, 399: 249-266,
2005.
31. J. Jin, T. Cardozo, R. Lovering, S. J.
Elledge, M. Pagano and J. W. Harper.
Systematic analysis and nomenclature of mammalian
F-box proteins.
Genes & Development
18:2573-2580, 2004.
30. L. Yamasaki and M. Pagano.
Cell cycle, proteolysis and cancer.
Curr Op in Cell Biol,
16:623-628, 2004.
29. M. Pagano and P. Jackson.
Wagging the Dogma: Tissue specific Cell Cycle Control
in the Mouse Embryo.
Cell, 118:535-538, 2004.
28. M. Pagano.
Control of DNA synthesis and Mitosis by the Skp2-p27-Cdk1/2
axis.
Mol Cell, 14:414-416 2004.
27. T. Bashir and M. Pagano.
Don’t skip the G1 phase: How APC/CCdh1 keeps SCFSkp2
in check.
Cell Cycle, 3:850-852,
2004.
26. T. Cardozo and M. Pagano.
The SCF ubiquitin ligase: insights into a molecular
mechanism.
Nature Rev Mol Cell Biol,
5: 739-753, 2004.
25. M. Pagano and R. Benmaamar.
When protein destruction runs amok, malignancy is
on the loose.
Cancer Cell, 4: 251-256,
2003.
24. J. Bloom and M. Pagano.
To be or not to be… ubiquitinated?
Cell
Cycle, 3:138-140, 2004.
23. D. Guardavaccaro and M. Pagano.
Oncogenic Aberrations of Cullin-Dependent Ubiquitin
Ligases.
Oncogene, 23:2037-2049,
2004.
22. J. Bloom and M. Pagano.
Cell cycle control.
In: Genetics. R. Robinson Ed. MacMillan Reference
USA Publishing 1:103-108, 2003.
21. T. Bashir and M. Pagano.
Aberrant ubiquitin-mediated proteolysis of cell
cycle regulatory proteins and oncogenesis.
Advances
in Cancer Research, 88: 101-144, 2003.
20. J. Bloom and M. Pagano.
Deregulated degradation of the cdk inhibitor p27
and malignant transformation.
Seminars in Cancer Biology,
13:41–47, 2003
19. J. Bloom and M. Pagano.
Regulation of p27 degradation.
In: The ubiquitin-proteasome proteolytic system.
A. Ciechanover and M. Masucci Eds. World
Scientific Publishing. 141-162, 2002.
18. J. Bloom and M. Pagano.
Butyrolactone: More than a Kinase Inhibitor?
Cell Cycle, 1:117-118, 2002.
17. R. Chiarle, M. Pagano and G. Inghirani.
The cyclin dependent kinase inhibitor p27 and its
prognostic role in breast cancer.
Breast Cancer Res 3:91-4, 2001.
16. L. Desalle and M. Pagano.
Regulation of the G1 to S transition by the ubiquitin
pathway.
FEBS Letters 490:179-189,
2001.
15. E. Kipreos and M. Pagano.
The F-box protein family.
Genome Biology 1: 3002.1-3002.7,
2000.
14. J. Slingerland and M. Pagano.
Regulation of the cdk inhibitor p27 and its deregulation
in cancer.
J Cell Physiology 183:
10-17, 2000.
13. M. Pagano and K. Ravid.
The cell cycle inhibitor p27 as a prognostic marker
in human tumors and a novel target for therapeutic
intervention.
In: Cancer drug discoveries and development:
Signaling networks and cell cycle control. J. S.
Gutkind Ed. Humana Publishing. Chapter 31. 545-556,
2000.
12. M. Pagano.
Protein degradation is not chaos.
Trends in Biochemical Sciences 24: 40-41, 1999.
11. J. Slingerland and M. Pagano.
Regulation of cyclin-dependent kinases by the ubiquitin
pathway.
In: Cell cycle control. M. Pagano Ed. Springer
Publishing. 133-147, 1998.
10. M. Pagano.
Regulation of cell cycle regulatory proteins by
the ubiquitin pathway.
FASEB J 11: 1067-1075, 1997.
9. J. P. Brown and M. Pagano.
Mechanism of p53 degradation.
Bioch et Bioph Acta 1332: 1-6, 1997.
8. A. Alessandrini, D. S. Chiaur, and M.
Pagano.
Regulation of the cell cycle inhibitor p27 by degradation
and phosphorylation.
Leukemia 11: 342-345, 1997.
7. M. Rolfe, I. Chiu, and M. Pagano.
The ubiquitin mediated proteolytic pathway as a
therapeutic area.
J of Molecular Medicine 75: 5-17, 1997.
6. G. Draetta and M. Pagano.
Cell cycle control and cancer.
In: Annual Reports in Medicinal Chemistry, Vol 31.
J. Bristol Ed. Academic Press. 241-248, 1996.
5. M. Pagano, P. Romero, S. Glass, S. W.
Tam, A. M. Theodoras, M. Rolfe, and G. Draetta.
Targeting ubiquitin-mediated degradation for proliferation
inhibitors.
In: Cancer Genes. Vol. 7. E. Mihich and D. Housman
Eds. Plenum Publishing Co., 241-254, 1996.
4. M. I. Chiu and M. Pagano.
An historical synopsis of cell cycle terms.
In: Cell cycle: materials and methods. M. Pagano
Ed. Springer Publishing. XVII-XXX, 1995.
3. M. Pagano.
From peptide to purified antibody.
In: Cell cycle: materials and methods. M. Pagano
Ed. Springer Publishing. 271-280, 1995.
2. M. J. Marcote, M. Pagano, and G. Draetta.
Cdc2 Protein Kinase: Structure-Function Relationship.
In: Regulation of the Eukaryotic cell cycle (Ciba
Foundation Symposium). Wiley, Chichester Publishing.
30-49, 1992.
1. M. Pagano and G. Draetta.
Cyclin A, cell cycle control and oncogenesis.
Progress in growth factor research 4: 267-277,
1991.
Books
Cell
Cycle Control. M. Pagano Ed.
Springer. 1998.
Cell
Cycle: Materials and Methods. M. Pagano
Ed. Springer. 1995.
(published in English and Chinese editions)
Patents
M. Pagano. Methods to identify compounds useful for tumor sensitization to DNA damage. PCT number WO/2005/04270. (priority date: October 21, 2003). U.S. Patent No. 7,439,032 (October 21, 2008)
J. McKenna, F. Mercurio, V. Plantevin, W.
Xie and M. Pagano.
4-{[3-(2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-YL)-4-PHENYL-BUTYLAMINO]
-METHYL}-PHENYL)-DIMETHYL-AMINE,
compositions and methods for use (June 16, 2003).
U.S. Patent No. 7,037,936 (May 2, 2006).
M. Pagano, E. Latres and D.S. Chiaur.
Novel Ubiquitin ligases
as therapeutic targets (August 28, 1998).
U.S. Patent No. 6,720,181 (April 13, 2004), Australia
Patent No. 767507 (June 15, 2004), Japan No. 2000567666 (July 2004), New Zealand Patent
No. 510312 (August 27, 2004)
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