Featured Publications:

INTS3 controls the hSSB1-mediated DNA damage response
J. Skaar, D. Richard, A. Toschi, A. Saraf, E. Bolderson, L. Florens, M. Washburn, K. Khanna, and M. Pagano
J of Cell Biol, 187:25-32, 2009.

βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
E. Dehan, F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K. Lowes, M. Dustin, D. Huang, J. Taunton, and M. Pagano
Mol Cell, 33:109-116, 2009.

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint
F. Bassermann, D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, M. Pagano
Cell, 134:256-267, 2008.

Control of chromosome stability by the βTRCP-REST-MAD2 axis
D. Guardavaccaro, D. Frescas, N. Dorrello, A. Peschiaroli, A. Multani, T. Cardozo, A. Lasorella, A. Iavarone, S. Chang, E. Hernando, and M. Pagano.
Nature, 452, 365-369, 2008.

The histone demethylase JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
D. Frescas, D. Guardavaccaro, F. Bassermann, R. Koyama-Nasu and M. Pagano
Nature, 450, 309-313, 2007.

SCF^Fbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins.
L. Busino, F. Bassermann, A. Maiolica, C. Lee, S. Godinho, P. Nolan, G. Draetta and M. Pagano
Science, 316:900-904, 2007.

APC/C^Cdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase
V. Amador, S. Ge, P.G. Santamaria, D. Guardavaccaro and M. Pagano
Mol Cell, 27, 462-473, 2007.

S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
N. V. Dorrello, A. Peschiaroli, D. Guardavaccaro, N. H. Colburn, N. E. Sherman and M. Pagano
Science, 314:467-471, 2006.

SCF^βTRCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
A. Peschiaroli, N. V. Dorrello, D. Guardavaccaro, M. Venere, T. Halazonetis, N. Sherman and M. Pagano.
Mol Cell, 23: 319-329, 2006